No-touch multibipolar radiofrequency ablation vs. surgical resection for solitary hepatocellular carcinoma ranging from 2 to 5 cm

Mohkam, Kayvan; Dumont, P.-N.; Manichon, Anne-Frédérique; Jouvet, Jean-Christophe; Boussel, Loîc; Merle, Philippe; Ducerf, C.; Lesurtel, Mickaël; Rode, Agnès; Mabrut, Jean‐Yves

doi:10.1016/j.jhep.2018.01.014

Cited by 86 publications

(77 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, our results may provide support for future prospective and randomized trials. Secondly, new technologies of RFA have emerged, particularly the no touch multibipolar RFA which may increase the limits of peri‐tumoral necrosis and decreases the rate of local recurrences in patients with early stage HCCs . Thus, we could infer that SR vs no touch multibipolar RFA may be more similar in outcomes in the treatment of very‐early stage HCC; however, comparative study between SR vs no touch multipolar RFA for very‐early stage HCC is required in the near future.…”

Section: Discussionmentioning

confidence: 99%

Surgical resection versus radiofrequency ablation very early‐stage HCC (≤2 cm Single HCC): A propensity score analysis

Chu

Kim

et al. 2019

Liver International

View full text Add to dashboard Cite

Background & aim: Hepatocellular carcinoma (HCC) is increasingly being detected at a very early-stage due to the wide implementation of the surveillance of at-risk patient populations combined with improved imaging technologies. Whether patients with HCC at a very early stage can be offered local ablation as a first-line treatment option still remains controversial. We retrospectively compared the effectiveness of surgical resection (SR) and radiofrequency ablation (RFA) for Barcelona Clinic Liver Cancer (BCLC) very early-stage HCC in patients with long-term follow-up.Methods: Propensity score analysis using inverse probability weighting (IPW) from a large-volume liver centre. We included adult patients who between 2000 and 2013 received a diagnosis of very early-stage HCC (BCLC stage 0; a single tumour ≤2 cm, Child-Pugh A class, eastern cooperative oncology group [ECOG] 0) and who were treated with SR or RFA as the first-line treatment. Results:We identified 1208 patients, 631 in the SR group and 577 in the RFA group.The median follow-up time was 86.2 months. After propensity score analysis using IPW, the 15-year overall survival rates were 60.4% and 51.6% in the SR and RFA group respectively. RFA group showed poorer overall survival than SR group (adjusted hazard ratio, 1.29; P = .0378). The 15-year recurrence-free survival rates were 37% and 23.6% in the SR and RFA group respectively (P < .001). Conclusion:For patients with very early-stage HCC, the SR group was associated with better overall and recurrence-free patient survival compared to the RFA group.Therefore, SR should be considered as the first-line treatment for these patients. K E Y W O R D Shepatocellular carcinoma, Barcelona Clinic Liver Cancer stage 0, surgical resection, radiofrequency ablation

show abstract

Section: Discussionmentioning

confidence: 99%

Surgical resection versus radiofrequency ablation very early‐stage HCC (≤2 cm Single HCC): A propensity score analysis

Chu

Kim

et al. 2019

Liver International

View full text Add to dashboard Cite

show abstract

“…Image-guided local ablation therapy was introduced as a radical treatment, which was useful to improve overall survival (OS) of patients [7][8][9]. Radiofrequency ablation (RFA) and microwave ablation (MWA) are two most often performed ablative treatments.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of the albumin-bilirubin grade on long-term outcomes of CT-guided percutaneous microwave ablation in intrahepatic cholangiocarcinoma

Zhang

et al. 2019

International Journal of Hyperthermia

View full text Add to dashboard Cite

2019) Predictive value of the albumin-bilirubin grade on long-term outcomes of CTguided percutaneous microwave ablation in intrahepatic cholangiocarcinomaABSTRACT Purpose: To assess the efficacy of the albumin-bilirubin (ALBI) grade on assessing long-term outcomes of computed tomography (CT)-guided percutaneous microwave ablation (CT-PMWA) in the treatment of patients with intrahepatic cholangiocarcinoma (ICC). Methods: Between April 2011 and March 2018, 78 patients who underwent CT-PMWA were enrolled in this study. Overall survival (OS) and recurrence-free survival (RFS) were compared in the groups stratified by the ALBI grade and Child-Pugh score. Cox proportional hazard regression analyses were performed to determine independent predictors of OS and RFS. Results: After a median follow-up of 22.7 months (range 1-86.7 months), 67 patients had died. The cumulative 1-, 3-, and 5-year OS rates were 89.5%, 52.2%, and 35.0%, respectively. Stratified by the ALBI grade, the cumulative 1-, 3-, and 5-year OS rates were 100%, 69.2%, and 25.6% for patients with the grade 1, respectively. For patients with the ALBI grade 2, the cumulative 1-, 3-, and 5-year OS rates were 41.0%, 10.3%, and 10.3%, respectively. Patients with a hepatic function of the ALBI grade 1 had significantly higher OS rates than patients with the ALBI grade 2 (p < .001). The multivariate analysis showed tumor size (Hazard Ratio[HR] 95% Confidence Interval[CI]:9.03[1.01-80.52], p ¼ .049) and the ALBI grade (HR[95%CI]:9.56[1.58-58.00], p ¼ .014) were associated with OS, and tumor size (HR: 2.03[0.69-8.

show abstract

“…Although a unified understanding has not been reached, the analysis of its effectiveness generally indicates that for small liver tumors with a diameter ≤3 cm, the long-term survival and tumor recurrence are similar [5]; for liver tumors with a diameter >5 cm, it is currently believed that RFA cannot achieve the effect of radical treatment [6]. However, for liver tumors with diameters of 3-5 cm, there is still considerable controversy on the effect of RFA [7][8][9]. Additionally, most studies that compare these two methods focus on the treatment or control of the tumor, while the safety of two treatment methods is ignored.…”

Section: Introductionmentioning

confidence: 99%

Comparison of open liver resection and RFA for the treatment of solitary 3-5 cm hepatocellular carcinoma: a retrospective study

Lei

Yan²,

Li³

et al. 2019

Preprint

View full text Add to dashboard Cite

Aim: The goal of this study was to compare the postoperative results of liver resection and radiofrequency ablation (RFA) for the treatment of small hepatocellular carcinoma (HCC) (3-5 cm). Patients and methods: We retrospectively collected 122 patients with small solitary HCC treated at our center from Jan 2011 to Dec 2015, with diameters in the range of 3-5 cm. According to the treatment program received at our center, they were divided into the liver resection group (72 patients) and the RFA group (50 patients). Result: In comparison with the RFA group, the resection group had a longer operative time, and greater intra-operative blood loss (P<0.01), more hepatic inflow occlusion , and longer postoperative hospital stay (P<0.01). The 1-, 3-, and 5-year expected overall survival rates and tumor-free survival rates were comparable between the two groups. Cox regression analysis showed that resection or RFA was not a significant risk factor for overall or tumor-free survival for HCC. Conclusions: For solitary HCC of 3-5 cm in diameter, RFA can achieve better in-hospital clinical results and similar long-term outcomes, and RFA can be considered for wide application, especially for central cases.

show abstract

No-touch multibipolar radiofrequency ablation vs. surgical resection for solitary hepatocellular carcinoma ranging from 2 to 5 cm

Cited by 86 publications

References 38 publications

Surgical resection versus radiofrequency ablation very early‐stage HCC (≤2 cm Single HCC): A propensity score analysis

Surgical resection versus radiofrequency ablation very early‐stage HCC (≤2 cm Single HCC): A propensity score analysis

Predictive value of the albumin-bilirubin grade on long-term outcomes of CT-guided percutaneous microwave ablation in intrahepatic cholangiocarcinoma

Comparison of open liver resection and RFA for the treatment of solitary 3-5 cm hepatocellular carcinoma: a retrospective study

Contact Info

Product

Resources

About

No-touch multibipolar radiofrequency ablation vs. surgical resection for solitary hepatocellular carcinoma ranging from 2 to 5 cm

Cited by 86 publications

References 38 publications

Surgical resection versus radiofrequency ablation very early‐stage HCC (≤2 cm Single HCC): A propensity score analysis

Surgical resection versus radiofrequency ablation very early‐stage HCC (≤2 cm Single HCC): A propensity score analysis

Predictive value of the albumin-bilirubin grade on long-term outcomes of CT-guided percutaneous microwave ablation in intrahepatic cholangiocarcinoma

Comparison of open liver resection and RFA for the treatment of solitary 3-5 cm hepatocellular carcinoma: a retrospective study

Contact Info

Product

Resources

About

No-touch multibipolar radiofrequency ablation vs. surgical resection for solitary hepatocellular carcinoma ranging from 2 to 5 cm