In this paper, the stimulated Brillouin scattering (SBS) media perfluoropolyether (PFPE) with unique physicochemical properties and SBS properties are researched. The PFPE has a small absorption coefficient and can be used to increase the load-ability of SBS system. The PFPE with a high boiling point and a low pouring point can operate at high and low temperatures, respectively. The SBS properties of PFPE have been analyzed in detail and validated in Q-switched Nd:YAG laser system. The experimental results indicate that the media not only have good SBS characteristics but also can be used in a wide temperature range, thereby has great advantage for experimental investigation on SBS phase-conjugated mirror at different temperatures.