No scientific evidence that alcohol causes sleepwalking

Pressman, Mark R.; Mahowald, Mark W.; Schenck, Carlos H.; Bornemann, Michel Cramer

doi:10.1111/j.1365-2869.2008.00694.x

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…The potential role of alcohol as a confounder in our analysis cannot be ruled out because alcohol information is badly recorded in ADR data. However, readers should note that the idea that alcohol itself causes sleepwalking is regarded as unsupported scientifically (Pressman et al. , 2008).…”

Section: Discussionmentioning

confidence: 99%

Spontaneous adverse event reports associated with zolpidem in Australia 2001-2008

Ben-Hamou¹,

Marshall

Grunstein

et al. 2011

Journal of Sleep Research

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SUMMAR Y A prominent media publicity cluster during [2007][2008] in Australia linked the common hypnotic zolpidem to adverse drug reaction reports of parasomnias, amnesia, hallucinations and suicidality. The collection of adverse drug reaction data through spontaneous reporting systems is a mainstay of drug safety monitoring, but a stimulated reporting event such as this often renders such data uninterpretable.As such, we aimed to investigate whether these associations were present before the media cluster and then to quantify the effect of stimulated reporting on those four specific outcomes. Using disproportionality analyses we compared zolpidem to all other drugs in the database, and then separately to each of all hypnotics, then all benzodiazepines, and then temazepam alone, and did so in every year from 2001 to 2008. Year-by-year analyses of Reporting odds ratios for zolpidem exposure and adverse events of interest, adjusted for a number of covariates, revealed an association between zolpidem exposure and parasomnias, amnesia and hallucination both before and after the cluster of media publicity beginning in early 2007. The odds ratios increased significantly after the media publicity for only parasomnias and amnesia. Suicidality was increased in some analyses, but limited data make this outcome difficult to interpret. We conclude that zolpidem adverse drug reaction reports have higher odds for parasomnia, amnesia, hallucination and perhaps suicidality compared to either all other drugs or hypnotics, even before the media publicity cluster. However, the extant literature and the limitations of these spontaneously reported adverse drug reaction data do not allow us to conclude that these events are related causally to zolpidem.k e y w o r d s insomnia, sleep, sleepdriving, sleepwalking

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Section: Discussionmentioning

confidence: 99%

Spontaneous adverse event reports associated with zolpidem in Australia 2001-2008

Ben-Hamou¹,

Marshall

Grunstein

et al. 2011

Journal of Sleep Research

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“…Although alcohol has the ability to interfere with normal intrinsic sleep physiology, 38 its role in the development of parasomnias is far from clear. 39 While prescribing guidelines recommend against co-administration of alcohol and zolpidem, there are numerous cases where patients have disregarded this advice and continued to use these agents concomitantly. As such, the potential role of alcohol as a confounder cannot be disregarded.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Adverse Event Reports Associated with Zolpidem in the United States 2003–2012

Wong

Marshall

Grunstein

et al. 2017

Journal of Clinical Sleep Medicine

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Although our results indicate that zolpidem reports have higher odds for the ADR of interest even before the media publicity cluster, negative media coverage greatly exacerbated the reporting of these adverse reactions. The effect of such reporting must be borne in mind when decisions around drugs which have been the subject of intense media publicity are made by health professionals or regulatory bodies.

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Sleep Forensics

Bornemann¹,

Mahowald²

2011

Principles and Practice of Sleep Medicine

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No scientific evidence that alcohol causes sleepwalking

Cited by 4 publications

References 13 publications

Spontaneous adverse event reports associated with zolpidem in Australia 2001-2008

Spontaneous adverse event reports associated with zolpidem in Australia 2001-2008

Spontaneous Adverse Event Reports Associated with Zolpidem in the United States 2003–2012

Sleep Forensics

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