NO-Releasing Zeolites and Their Antithrombotic Properties

Abstract

Transition metal-exchanged zeolite-A adsorbs and stores nitric oxide in relatively high capacity (up to 1 mmol of NO/g of zeolite). The stored NO is released on contact with an aqueous environment under biologically relevant conditions of temperature and pH. The release of the NO can be tuned by altering the chemical composition of the zeolite, by controlling the amount of water contacting the zeolite, and by blending the zeolite with different polymers. The high capacity of zeolite for NO makes it extremely attractive for use in biological and medical applications, and our experiments indicate that the NO released from Co-exchanged zeolite-A inhibits platelet aggregation and adhesion of human platelets in vitro.

Theoretical Studies of Substitutionally Doped Single-Walled Nanotubes

“…Thus, the ability to adsorb NO would be important because it would reduce its concentration, which can be beneficial or dangerous depending on the site of activity. The controlled release of NO has recently attracted attention of researchers for antithrombotic activity [144], for instance. Indeed, chemically designed drugs ( Figure 4) [136], zeolites [144,145], and even Pt nanoparticles [146] may find applicability in NO homeostasis.…”

Supramolecular photochemistry in zeolites: From catalysts to sunscreens

“…Zeolites have already found some limited use in the medical sciences as MRI contrast agents and anticoagulant-releasing materials for medical implants [146,147]. Hopefully, the preliminary investigations of encapsulated sunscreens described here will provide yet another avenue of exploration for zeolite-based materials.…”

Ionothermal Synthesis of a Novel 3D Cobalt Coordination Polymer with a Uniquely Reported Framework: [BMI]2[Co2(BTC)2(H2O)2]

“…The rising demands for new materials with befitted properties for applications in numerous fields of science and industry [1][2][3] have led to development and advancements of novel synthesis methods [4][5][6][7][8][9][10]. Ionothermal synthesis, where ionic liquids are used both as solvents and templates [11], has been recently deployed for preparation of novel structures [12,13] amidst a great attention attributed to its unique and pragmatic physicochemical properties [11], namely, those discussed hereafter and many more [14][15][16]: high thermal stability [17], negligible vapor pressure [18], environmentally friendliness [19], and, most interestingly, its ability to finely tune the reaction environment by changing the cation and anion of the ionic liquid and ultimately enabling systematic approach to the final product [20,21].…”