No radiographic sacroiliitis progression was observed in patients with early spondyloarthritis at 6 years: results of the Esperanza multicentric prospective cohort

Abstract

ObjectiveTo estimate the 6-year radiographic progression of sacroiliitis in patients with early spondyloarthritis (SpA).Patients and methodsSacroiliac joint (SIJ) radiographs (baseline and 6 years) of 94 patients with recent-onset SpA from the Esperanza cohort were scored, blindly and in a random order, by nine readers. The modified New York criteria were used to define the presence of sacroiliitis. As the gold standard for radiographic (r) sacroiliitis, the categorical opinion of at least five readers was used. Progression was defined as the shift from non-radiographic (nr) to r-sacroiliitis.ResultsIn the 94 SIJ radiographs (baseline and 6 years), 78/94 (83%) pairs of radiographs had not changed from baseline to 6 years. Sacroiliitis was present in 20 patients at baseline (21.3%) and in 18 (19.2%) patients at 6 years; 11 patients had sacroiliitis at both the baseline and final visits; 9 patients changed from baseline r-sacroiliitis to nr-sacroiliitis at 6 years, and 7 changed from baseline nr-sacroiliitis to r-sacroiliitis at 6 years. The mean continuous change score (range: −8 to +8) was 2.80 at baseline and 2.55 at 6 years (mean net progression of −0.25). The reliability of the readers was fair (mean inter-reader kappa of 0.375 (0.146–0.652) and mean agreement of 73.7% (58.7–90%)).ConclusionIn the early SpA Esperanza cohort, progression from nr-axSpA to r-axSpA over 6 years was not observed, although the SIJ radiographs scoring has limitations to detect low levels of radiographic progression.

7 year of sacroiliac radiographic progression in early psoriatic arthritis (preliminary results)

“…В ранней испанской когорте аксСпА Esperanza прогрессирования от нр-аксСпА до рл-аксСпА в течение 6 лет не наблюдалось: СИ присутствовал у 20 (21,3%) пациентов исходно и у 18 (19,2%) пациентов через 6 лет; у 11 пациентов СИ был как при первом, так и при последнем посещении; у 9 пациентов исходный рл-СИ сменился на нр-СИ через 6 лет, а у 7 исходный нр-СИ -на рл-СИ. Однако отмечалось, что оценка рентгенограмм КПС имеет ограничения для выявления начальных стадий рентгенологического прогрессирования [11]. В нашем исследовании также было отмечено уменьшение стадии СИ с III на II у 1 пациента через 7 лет.…”

Similarities and Differences Between Juvenile and Adult Spondyloarthropathies

“…In contrast to adult SpA, patients with JSpA are not confined to one group but are divided between three subtypes of JIA: ERA, juvenile onset psoriatic arthritis and undifferentiated JIA (Table 1). The term ERA was developed in recognition of the distinct clinical presentation of childhood disease and replaced others including seronegative enthesopathy and arthropathy (SEA) (9), juvenile AS and JSpA.…”

Burden of idiopathic inflammatory rheumatic diseases in occupational healthcare: increased absenteeism and healthcare resource utilization

“…Idiopathic inflammatory rheumatic diseases (IIRD) are a group of chronic conditions characterized by pain, stiffness, and impaired function in the musculoskeletal system (1). Although modern drug treatment can in many cases alleviate symptoms (2) and reduce the risk of structural damage in joints and the back (3,4), many patients still suffer from pain and functional limitations. These can, among employed patients, result in impairment of working ability manifesting as reduced productivity while at work (presenteeism), sick leaves (absenteeism), and work disability pensions.…”