No Platelet Can Adhere—Largely Improved Blood Compatibility on Nanostructured Superhydrophobic Surfaces

Sun, Taolei; Tan, Hong; Han, Dong; Fu, Qiang; Jiang, Lei

doi:10.1002/smll.200500095

Cited by 295 publications

(224 citation statements)

References 35 publications

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“…Anti-bioadhesion applications, aimed at preventing protein adsorption and cell adhesion have been mostly studied in blood compatible materials [21,22]. Nonetheless, few works are found in literature reporting the use of superhydrophobic surfaces as support for cell response studies [23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Wettability Influences Cell Behavior on Superhydrophobic Surfaces with Different Topographies

et al. 2012

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Surface wettability and topography are recognized as critical factors influencing cell behavior on biomaterials. So far only few works have reported cell responses on surfaces exhibiting extreme wettability in combination with surface topography. The goal of this work is to study whether cell behavior on superhydrophobic surfaces is influenced by surface topography and polymer type. Biomimetic superhydrophobic rough surfaces of polystyrene and poly(l-lactic acid) with different micro/nanotopographies were obtained from smooth surfaces using a simple phase-separation based method. Total protein was quantified and showed a less adsorption of bovine serum albumin onto rough surfaces as compared to smooth surfaces of the same material. The mouse osteoblastic MC3T3-E1 cell line and primary bovine articular chondrocytes were used to study cell attachment and proliferation. Cells attached and proliferate better in the smooth surfaces. The superhydrophobic surfaces allowed cells to adhere but inhibited their proliferation. This study indicates that surface wettability, rather than polymer type or the topography of the superhydrophobic surfaces, is a critical factor in determining cell behavior.

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Section: Introductionmentioning

confidence: 99%

Wettability Influences Cell Behavior on Superhydrophobic Surfaces with Different Topographies

et al. 2012

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“…Highly hydrophilic surfaces are usually used to reduce protein fouling. 7,8 It has, however, been suggested that superhydrophobic surfaces could reduce the extent of protein adsorption due to the reduction in solid surface area at the liquid interface (Cassie-Baxter bridging case only) 13,14,15 . A recent publication highlights the possibilities of superhydrophobic coatings but also shows how little work has been undertaken in this area.…”

Section: Introductionmentioning

confidence: 99%

Nano-scale superhydrophobicity: suppression of protein adsorption and promotion of flow-induced detachment

et al. 2008

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“…Studies show that DMSO does not exert toxicity to human vascular endothelial cells, further solidifying this technique as a potentially viable option for polymers and SMPs [92]. Dip coating, used to form nanostructures on the surface of medical-grade polymers, creates superhydrophobic surfaces that prevent blood coagulation [93]. Coating polymers with polyelectrolyte multilayers provides a good platform for endothelial cells on polymer surfaces [6].…”

Section: Surface Coatings and Filmsmentioning

confidence: 99%

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

Govindarajan

Shandas

2014

Polymers

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Abstract:The search for a single material with ideal surface properties and necessary mechanical properties is on-going, especially with regard to cardiovascular stent materials. Since the majority of stent problems arise from surface issues rather than bulk material deficiencies, surface optimization of a material that already contains the necessary bulk properties is an active area of research. Polymers can be surface-modified using a variety of methods to increase hemocompatibilty by reducing either late-stage restenosis or acute thrombogenicity, or both. These modification methods can be extended to shape memory polymers (SMPs), in an effort to make these materials more surface compatible, based on the application. This review focuses on the role of surface modification of materials, mainly polymers, to improve the hemocompatibility of stent materials; additional discussion of other materials commonly used in stents is also provided. Although shape memory polymers are not yet extensively used for stents, they offer numerous benefits that may make them good candidates for next-generation stents. Surface modification techniques discussed here include roughening, patterning, chemical modification, and surface modification for biomolecule and drug delivery.

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No Platelet Can Adhere—Largely Improved Blood Compatibility on Nanostructured Superhydrophobic Surfaces

Cited by 295 publications

References 35 publications

Wettability Influences Cell Behavior on Superhydrophobic Surfaces with Different Topographies

Wettability Influences Cell Behavior on Superhydrophobic Surfaces with Different Topographies

Nano-scale superhydrophobicity: suppression of protein adsorption and promotion of flow-induced detachment

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

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