No Phenotypic Differences for Polycystic Ovary Syndrome (PCOS) Between Women With and Without Type 1 Diabetes Mellitus

Amato, Marco; Guarnotta, Valentina; Ciresi, Alessandro; Modica, Roberta; Pantò, Felicia

doi:10.1210/jc.2013-2669

Cited by 28 publications

(36 citation statements)

References 41 publications

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Section: Systematic Reviewmentioning

confidence: 92%

“…In several studies, the mean hirsutism score was lower in women with type 1 diabetes and PCOS than in their counterparts without diabetes (9,15,31), whereas no differences were found in others (16,26,28). The hormonal profiles of patients with PCOS, with or without type 1 diabetes, were comparable in circulating total testosterone concentrations in most studies (9,15,16,26), yet the cause of the increased free testosterone or free androgen index in patients with PCOS appears to derive from specific mechanisms in women with type 1 diabetes (15). In women with type 1 diabetes and PCOS, sex hormone-binding globulin (SHBG) concentrations are comparable to those of non-PCOS women with type 1 diabetes (9,16,26,28) or healthy control subjects (9,13,26) instead of being reduced as occurs in most women with PCOS but without diabetes (9,26,32).…”

Section: Systematic Reviewmentioning

confidence: 92%

“…Six addressed fertility issues and eighteen addressed menstrual cycle characteristics of type 1 diabetes but were unrelated to androgen excess ( Fig. 1 and Supplementary Data), leaving seventeen original articles dealing with androgen excess (8)(9)(10)(11)(12)(13)(14)(15)(16)(24)(25)(26)(27)(28)(29)(30)(31). Only 9 of these 17 articles contained data about the prevalence of PCOS and related traits (8,(10)(11)(12)(13)(14)(15)(16)28) and were included in the meta-analyses.…”

Section: Data Synthesis and Analysismentioning

confidence: 99%

“…Of note, even though this association was confirmed by all of the studies that addressed the issue thereafter (10)(11)(12)(13)(14)(15)(16), with prevalences of PCOS as high as 40% in some series (10,16), this syndrome is seldom diagnosed and treated in women with type 1 diabetes.…”

mentioning

confidence: 94%

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Type 1 Diabetes and Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Escobar-Morreale

Roldán-Martín

2016

Diabetes Care

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A few small studies have reported increased prevalences of polycystic ovary syndrome (PCOS) and symptoms of androgen excess in women with type 1 diabetes. PURPOSEWe performed a systematic review and meta-analysis of studies evaluating androgen excess symptoms and PCOS in women with type 1 diabetes. DATA SOURCESThe Entrez-PubMed and Scopus electronic databases were used. STUDY SELECTIONWe selected studies addressing androgen excess signs, symptoms, and disorders in girls, adolescents, and adult women with type 1 diabetes. DATA EXTRACTIONThe main outcome measures were prevalences of PCOS, hyperandrogenemia, hirsutism, menstrual dysfunction, and polycystic ovarian morphology (PCOM). DATA SYNTHESISNine primary studies involving 475 adolescent or adult women with type 1 diabetes were included. The prevalences of PCOS and associated traits in women with type 1 diabetes were 24% (95% CI 15-34) for PCOS, 25% (95% CI 17-33) for hyperandrogenemia, 25% (95% CI 16-36) for hirsutism, 24% (95% CI 17-32) for menstrual dysfunction, and 33% (95% CI 24-44) for PCOM. These figures are considerably higher than those reported earlier in the general population without diabetes. LIMITATIONSThe data collected in the original studies were heterogeneous in age, race, ethnicity, and criteria used for the diagnosis of PCOS; yet, we used a quality-effects model in the meta-analyses to overcome this limitation. CONCLUSIONSPCOS and its related traits are frequent findings in women with type 1 diabetes. PCOS may contribute to the subfertility of these women by a mechanism that does not directly depend on glycemic/metabolic control among other negative consequences for their health. Hence, screening for PCOS and androgen excess should be included in current guidelines for the management of type 1 diabetes in women.

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Section: Systematic Reviewmentioning

confidence: 92%

Section: Systematic Reviewmentioning

confidence: 92%

Section: Data Synthesis and Analysismentioning

confidence: 99%

mentioning

confidence: 94%

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Type 1 Diabetes and Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Escobar-Morreale

Roldán-Martín

2016

Diabetes Care

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“…The prevalence of PCOS in women with type 1 diabetes was 40%, biochemical hyperandrogenism was present in 20% of the patients and PCO was present in 50% (102). In patients with type 1 diabetes, the presence of PCOS was, however, not associated with differences in medical treatment and glycemic control (103) and the phenotype of women with PCOS was not affected by the presence of type 1 diabetes (103). The role of metformin treatment in patients with simultaneous type 1 diabetes and PCOS remains to be established.…”

Section: Autoimmune Inflammatory and Infectious Diseases In Pcosmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Glintborg

Andersen

2017

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) is the most prevalent endocrine condition in premenopausal women. The syndrome is characterized by hyperandrogenism, irregular menses and polycystic ovaries when other etiologies are excluded. Obesity, insulin resistance and low vitamin D levels are present in more than 50% patients with PCOS, these factors along with hyperandrogenism could have adverse effects on long-term health. Hyperinflammation and impaired epithelial function were reported to a larger extent in women with PCOS and could particularly be associated with hyperandrogenism, obesity and insulin resistance. Available data from register-based and data linkage studies support that metabolic-vascular and thyroid diseases, asthma, migraine, depression and cancer are diagnosed more frequently in PCOS, whereas fracture risk is decreased. Drug prescriptions are significantly more common in PCOS than controls within all diagnose categories including antibiotics. The causal relationship between PCOS and autoimmune disease represents an interesting new area of research. PCOS is a lifelong condition and long-term morbidity could be worsened by obesity, sedentary way of life, Western-style diet and smoking, whereas lifestyle intervention including weight loss may partly or fully resolve the symptoms of PCOS and could improve the long-term prognosis. In this review, the possible implications of increased morbidity for the clinical and biochemical evaluation of patients with PCOS at diagnosis and follow-up is further discussed along with possible modifying effects of medical treatment.

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Prevalence of polycystic ovary syndrome and its clinical and hormonal profile in young females with type 1 diabetes mellitus: experience from a teaching institution of India

Dominic,

Sharma,

Mohindra

et al. 2023

Endocrine

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ObjectiveTo investigate the prevalence of polycystic ovary syndrome and its clinical and hormonal pro le in females with type 1 diabetes. Materials and methods65 T1DM females were evaluated for presence of PCOS and compared with age and BMI matched females with PCOS without diabetes. ResultsAccording to Rotterdam criteria 18/65 (27%) had PCOS. Prevalence of androgen excess, hirsutism, menstrual dysfunction and PCOM was 26%, 3%, 21% and 52% respectively. The females with T1DM who had PCOS did not differ from group without PCOS. Among those who had PCOS, the mean daily insulin dose (U/kg/day) was higher in girls who had post-pubertal onset of diabetes (median, IQR; 1.2, 0.95-1.56) vs pre-pubertal (0.81, 0.75-1.2) (p=0.055) which was close to statistical signi cance.When the group of T1DM with PCOS was compared with PCOS females without diabetes, they had signi cantly lower hirsutism score (median, IQR; 1.5, 0-3 vs. 11.5, 0 -16.5, p= 0.04), signi cantly higher waist hip ratio (0.91, 0.89-0.99 vs. 0.86, 0.80 -0.89, p= 0.004) and SHBG (in nmol, 54.4, 38-86.2 vs. 28.3, 20.4-37.4, p= 0.004) ConclusionFemales with T1DM have a high prevalence of menstrual abnormalities, hyperandrogenism and PCOS which is not related to metabolic control, age of onset of diabetes or insulin dose.

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No Phenotypic Differences for Polycystic Ovary Syndrome (PCOS) Between Women With and Without Type 1 Diabetes Mellitus

Abstract: The women with PCOS-DM1 do not exhibit particular phenotypic characteristics compared with nondiabetic women with PCOS. However, this pathological disorder must not be underestimated because it could be an additional cardiovascular risk factor in women with DM1.

Cited by 28 publications

References 41 publications

Type 1 Diabetes and Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Type 1 Diabetes and Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Prevalence of polycystic ovary syndrome and its clinical and hormonal profile in young females with type 1 diabetes mellitus: experience from a teaching institution of India

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