2011
DOI: 10.1007/s12041-011-0064-z
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No major genes in autoimmune thyroid diseases: complex segregation and epidemiological studies in a large Tunisian pedigree

Abstract: Bougacha-Elleuch N., Arab S. B., Rebai A., Mnif M., Maalej A., Charfi N., Lassouad M. B., Jovida J., Abid M. and Ayadi H. 2011 No major genes in autoimmune thyroid diseases: complex segregation and epidemiological studies in a large Tunisian pedigree. J. Genet. 90, 333-337]

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Cited by 4 publications
(6 citation statements)
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“…In order to decide between existence and absence of such a component, we have recently performed a complex segregation analysis of AITDs in the region harbouring Akr family. Our results gave evidence for a polygenic character of these diseases suggesting that genetic susceptibility to AITDs results from numerous loci, each contributing with small effects rather than a major one (Bougacha-Elleuch et al, 2011).…”
Section: Complex Segregation Analysismentioning
confidence: 66%
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“…In order to decide between existence and absence of such a component, we have recently performed a complex segregation analysis of AITDs in the region harbouring Akr family. Our results gave evidence for a polygenic character of these diseases suggesting that genetic susceptibility to AITDs results from numerous loci, each contributing with small effects rather than a major one (Bougacha-Elleuch et al, 2011).…”
Section: Complex Segregation Analysismentioning
confidence: 66%
“…In a district from the central east of Tunisia, where "Akr" family members live, the prevalence and incidence of AITDs were 4.36% and 7.2 per 1000 inhabitants per year respectively. Particularly, the prevalence of autoimmune hypothyroidism was 2.13% (Bougacha-Elleuch et al, 2011).…”
Section: Epidemiologymentioning
confidence: 99%
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“…The prevalence of GD and AH was 23.31‰ and 21.33‰ respectively. The estimated incidence of AITD was 7.21 per 1000 inhabitants in the studied region ( Bougacha-Elleuch et al, 2011 ). Therefore, with such high frequencies, AITD constitute a public health problem in this region particularly with its low life level.…”
Section: Discussionmentioning
confidence: 99%
“…In a recent study, we have given evidence for a polygenic model corresponding to AITD where the different genes contribute each only a small risk of disease ( Bougacha-Elleuch et al, 2011 ). Thus, if we consider the CTLA4 gene which is among the most replicated gene in AITD susceptibility, the corresponding relative risk is of just 1.3–1.7.…”
Section: Introductionmentioning
confidence: 99%