NO inhibitory constituents as potential anti-neuroinflammatory agents for AD from Blumea balsamifera

Ma, Jun; Ren, Quanhui; Dong, Bangjian; Shi, Zhaoyu; Zhang, Jie; Jin, Da Qing; Xu, Jing; Ohizumi, Yasushi; Lee, Dong Hoon; Guo, Yuanqiang

doi:10.1016/j.bioorg.2017.12.008

Cited by 27 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… Bacoside A3, bacopaside II, bacopasaponin C, bacopaside X Inhibits β-amyloid (Aβ) and fibrilation Alzheimer’s disease, memory loss [ 41 ] Blumea balsamifera DC. Blumpenes A, B, C, and D Inhibition of NO Alzheimer’s disease [ 158 ] Cannabis sativa L. Δ 9 -Tetrahydrocannabinol Inhibits β-amyloid Alzheimer’s disease [ 285 ] Attenuates the motor coordination deficits and huntingtin aggregate Huntington’s disease [ 85 ] Prevent neuronal damage Parkinson’s disease [ 286 ] Cannabidiol Reduces Aβ–induced neuroinflammation Alzheimer’s disease [ 287 ] Prevent neuronal damage Parkinson’s disease [ 286 ] Centella asiatica (L.) Urb. Asiatic acid Prevent MPTP/p-induced neuronal cells loss Parkinson’s disease [ 47 ] Citrus grandis Osbeck 3,5,6,7,8,3′,4′-Heptamethoxyflavone Induce activation of ERK1/2 and CREB in cultured neurons Memory disorders, Alzheimer’s disease [ 264 ] Clerodendrum infortunatum L. (Syn: Clerodendrum viscosum Vent.)…”

Section: Cns-active Natural Productsmentioning

confidence: 99%

“… Molisima Herb Root Epilepsy NRE [ 101 ] Compositae Ageratum conyzoides L. Dochunti Herb Whole plant Headache, Paralysis (Kh) Vertigo Antinociceptive [ 89 , 99 , 118 , 157 ] Blumea balsamifera DC. Kakronda Shrub Leaves Headache, insomnia Inhibition of NO (Alzheimer's disease) [ 158 , 159 ] Emilia sonchifolia DC. Sadimodi Herb Leaves Paralysis (Ch) Antinociceptive [ 160 , 161 ] Eupatorium ayapana Vent.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Uddin

Zidorn

2020

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

The majority of the population in Bangladesh uses traditional plant-based medicines to manage various ailments, including central nervous system (CNS) disorders. This review presents ethnobotanical information and relevant scientific studies on plants used in traditional healthcare for the management of various CNS disorders in Bangladesh. The information on the medicinal plants of Bangladesh effective against CNS disorders published in scientific journals, books, and reports was compiled from different electronic databases using specific key words. The present article provides comprehensive information on a total of 224 medicinal plant species belonging to 81 families used for the treatment of CNS disorders by the various peoples of Bangladesh. In total, we reviewed more than 290 relevant papers. In this study, leaves were found as the most often used plant organ, followed by roots, fruits, whole plants, barks, seeds, stems, rhizomes, and flowers. The Fabaceae family contributes the highest number of used species, followed by Rubiaceae, Lamiaceae, Cucurbitaceae, Vitaceae, Euphorbiaceae, Malvaceae, and Zingiberaceae. The most frequently used species (in decreasing order) are Asparagus racemosus, Centella asiatica, Stephania japonica, Aegle marmelos, Coccinia grandis, Tabernaemontana divaricata, Bacopa monnieri, Abroma augusta, and Scoparia dulcis. This review may serve as a starting point for a rational search for neuroactive natural products against CNS disorders within the Flora of Bangladesh. Graphic Abstract

show abstract

Section: Cns-active Natural Productsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Uddin

Zidorn

2020

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

show abstract

“…The correlation spectroscopy (COSY) correlation between H-7′ (δH 4.18) and H-8′ (δH 3.24), and the HMBC experiment revealed aryltetralin lactone type lignan (Figure 4). Considering a 13 C NMR data of 2 were similar to those of 1 (Table 1), although the NMR solvents were different from each other due to the different solubility of the compounds. Comparison of the 13 C NMR data and molecular weights from 1 and 2 suggested that the carbons C-8 and C-8 of 1 with a double bonded linkage (δ C 160.9 and 128.2) were replaced by an oxygenated quaternary (δ C 78.0) and methine (δ C 56.2) carbon atoms.…”

Section: Structure Elucidation Of Compounds 1 Andmentioning

confidence: 63%

“…The software AutoDock Vina with AutoDock Tools (The Scripps Research Institute, La Jolla, CA, USA: ADT 1.5.6) using the hybrid Lamarckian Genetic Algorithm (LGA) was used for performing molecular docking simulations as reported in the literature [13,14]. In short, the 3D crystal structures (resolution: 2.5 Å) of iNOS (PDB code: 3E6T) and COX-2 (PDB code: 1PXX) were obtained from the RCSB Protein Data Bank.…”

Section: Molecular Docking Studiesmentioning

confidence: 99%

Chemical Constituents of the Leaves of Butterbur (Petasites japonicus) and Their Anti-Inflammatory Effects

et al. 2019

Self Cite

View full text Add to dashboard Cite

Two new aryltetralin lactone lignans, petasitesins A and B were isolated from the hot water extract of the leaves of butterbur (Petasites japonicus) along with six known compounds. The chemical structures of lignans 1 and 2 were elucidated on the basis of 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectra. Petasitesin A and cimicifugic acid D showed significant inhibitory effects on the production of both prostaglandin E2 (PGE2) and NO in RAW264.7 macrophages. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were inhibited by compound 1 in RAW264.7 cells. Furthermore, compounds 1 and 3 exhibited strong affinities with both iNOS and COX-2 enzymes in molecular docking studies.

show abstract

“…In China, it is called as Ai-Na-Xiang, whereas in Philippines it is called Sembung. B. balsamifera showed lots of biological effects on stomach, respiratory system [1], nervous system [2], and also showed sudorific [3], antifungal [4], anticancer [5,6], and antiobesity [4] effects.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Quantitative Determination of Polyphenolic Compounds in Blumea balsamifera (Ai-Na-Xiang, Sembung) by High-Performance Liquid Chromatography with Photodiode Array Detector

Tan

Zhou

Zhang

et al. 2020

International Journal of Analytical Chemistry

View full text Add to dashboard Cite

A high-performance liquid chromatography method was developed for simultaneous quantification of 18 polyphenolic compounds from the leaves of Blumea balsamifera, including 17 flavonoids and 1 phenylethanone. The B. balsamifera extraction was separated by a Kromasil C18 column (250 × 4.6 mm, 5 μm) with a binary gradient mobile phase consisting of acetonitrile and 0.2% aqueous acetic acid. A photodiode array detector (PDA) was used to record the signals of investigated constituents. The linearity, sensitivity, stability, precision, and accuracy of the established assay methods were assessed to meet the requirements of quantitative determination. Samples extracted by reflux in 25 mL of 80% methanol for 30 minutes were selected for the extraction method. The 18 compounds were accurately identified by comparing with the reference compounds. The purity of each peak was confirmed by the base peak in the mass spectrum. The contents of 18 compounds in Blumea samples from four different regions were successfully determined. The results also showed that 3,3′,5,7-tetrahydroxy-4′-methoxyflavanone was the most abundant constituent, which could be used as a potential chemical marker for quality control of B. balsamifera and Chinese patent medications containing B. balsamifera herb.

show abstract

NO inhibitory constituents as potential anti-neuroinflammatory agents for AD from Blumea balsamifera

Cited by 27 publications

References 37 publications

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Chemical Constituents of the Leaves of Butterbur (Petasites japonicus) and Their Anti-Inflammatory Effects

Simultaneous Quantitative Determination of Polyphenolic Compounds in Blumea balsamifera (Ai-Na-Xiang, Sembung) by High-Performance Liquid Chromatography with Photodiode Array Detector

Contact Info

Product

Resources

About