No increased risk of sudden sensorineural hearing loss following recent herpes zoster: a nationwide population-based study

Sheu, Jau Jiuan; Keller, Joseph J.; Chen, Yi Hua; Wu, Cheng-Shong; Lin, Herng Ching

doi:10.3109/00016489.2011.633227

Cited by 8 publications

(5 citation statements)

References 19 publications

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“…The etiology and pathogenesis of MD is endolymphatic hydrops [ 22 ], but the etiology and pathogenesis of sudden deafness remain unknown. Proposed theories as to the cause of sudden deafness include vascular occlusion, tearing of the labyrinthine membranes, immune-mediated mechanisms [ 23 ], abnormal cellular stress responses within the cochlea [ 24 ], and viral infection [ 25 ] or reactivation of herpes zoster virus [ 23 ], which are suggested to be influenced by stress hormone due to a physical disorder or fatigue. Thanks to the evacuation centers and temporary housing that were quickly prepared soon after the disaster, victims were comparatively less apt to be physically fatigued.…”

Section: Discussionmentioning

confidence: 99%

Change in and Long-Term Investigation of Neuro-Otologic Disorders in Disaster-Stricken Fukushima Prefecture: Retrospective Cohort Study before and after the Great East Japan Earthquake

et al. 2015

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On March 11, 2011, Japan’s northeast Pacific coast was hit by a gigantic earthquake and subsequent tsunami. Soma City in Fukushima Prefecture is situated approximately 44 km north of Fukushima Daiichi Nuclear Power Plant. Soma General Hospital is the only hospital in Soma City that provides full-time otolaryngological medical care. We investigated the changes in new patients from one year before to three years after the disaster. We investigated 18,167 new patients treated at our department during the four years from April 1, 2010 to March 31, 2014. Of the new patients, we categorized the diagnoses into Meniere’s disease, acute low-tone sensorineural hearing loss, vertigo, sudden deafness, tinnitus, and facial palsy as neuro-otologic symptoms. We also investigated the changes in the numbers of patients whom we examined at that time concerning other otolaryngological disorders, including epistaxis, infectious diseases of the laryngopharynx, and allergic rhinitis. The total number of new patients did not change remarkably on a year-to-year basis. Conversely, cases of vertigo, Meniere’s disease, and acute low-tone sensorineural hearing loss increased in number immediately after the disaster, reaching a plateau in the second year and slightly decreasing in the third year. Specifically, 4.8% of patients suffering from these neuro-otologic diseases had complications from depression and other mental diseases. With regard to new patients in our department, there was no apparent increase in the number of patients suffering from diseases other than neuro-otologic diseases, including epistaxis, and allergic rhinitis. Patients suffering from vertigo and/or dizziness increased during the first few years after the disaster. These results are attributed to the continuing stress and tension of the inhabitants. This investigation of those living in the disaster area highlights the need for long-term support.

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Section: Discussionmentioning

confidence: 99%

Change in and Long-Term Investigation of Neuro-Otologic Disorders in Disaster-Stricken Fukushima Prefecture: Retrospective Cohort Study before and after the Great East Japan Earthquake

et al. 2015

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“…Several previous studies have reported no association between idiopathic SSNHL and HZV infection [9,37]. However, there were several limitations in the previously published studies.…”

Section: Discussionmentioning

confidence: 88%

“…However, there were several limitations in the previously published studies. After being diagnosed with HZ, the follow-up period was only three months [9], or patients who received steroid treatment with HZ oticus were matched [29]. When matching the two groups, it is also important to manage underlying diseases that may affect the patient's immunity.…”

Section: Discussionmentioning

confidence: 99%

“…A study that followed up on the incidence of SSNHL for two months in patients who had recently suffered from HZ reported no correlation between the two diseases. However, the follow-up period was too short to confirm the effect [9]. This study aimed to compare the incidence of SSNHL in patients diagnosed with and treated for HZ and the control group by analyzing the data from the National Health Insurance Service over 13 years.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Herpes Zoster Treatment and Sudden Sensorineural Hearing Loss Using National Health Insurance Claims Data of South Korea

et al. 2023

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Background and objectives: Herpes zoster (HZ) is caused by the reactivation of a pre-existing latent varicella zoster virus, which is one of the viruses that causes hearing loss, and hearing loss may occur due to a systemic immune response even if it does not invade the auditory nerve. This study aimed to determine the correlation between sudden sensorineural hearing loss (SSNHL) in older adult patients who received HZ treatment. Materials and Methods: We used the cohort data of patients aged 60 years and above (n = 624,646) between 2002 and 2015 provided by the National Health Insurance Service. The patients were divided into two groups: those who were diagnosed with HZ between 2003 and 2008 (group H, n = 36,121) and those who had not been diagnosed with HZ between 2002 and 2015 (group C, n = 584,329). Results: In the main model (adjusted HR = 0.890, 95% CI = 0.839–0.944, p < 0.001) adjusted for sex, age, and income, and the full model (adjusted HR = 0.894, 95% CI = 0.843–0.949, p < 0.001) adjusted for all comorbidities, group H had a lower risk of SSNHL than group C. Conclusions: This study showed that patients who received HZ treatment had a lower incidence of SSNHL within five years after diagnosis.

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“…Based on basic epidemiological data, the author concluded that sudden deafness was not associated with reactivation of this virus, except in the case of herpes zoster oticus, but sudden deafness may also be associated with hypertension and diabetes. 33…”

Section: Virus Reactivationmentioning

confidence: 99%

Role of viral infection in sudden hearing loss

Chen

Zhang

2019

J Int Med Res

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According to a recent epidemiological survey, the incidence of sudden sensorineural hearing loss (SSNHL) is increasing yearly. The cause of SSNHL is of great interest in research. To date, viral infection, vascular occlusion, abnormal cellular stress responses within the cochlea, and immune-mediated mechanisms are considered the most likely etiologies of this disease. Among these etiologies, the relationship between viral infection and sudden deafness has been unclear. In this review, we mainly discuss the viral hypothesis of SSNHL. There is little research proving or clearly indicating the pathogenesis of this disease. Further research is needed to elucidate the precise etiopathogenesis to better understand SSNHL and establish more suitable treatment to help restore hearing in affected patients.

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No increased risk of sudden sensorineural hearing loss following recent herpes zoster: a nationwide population-based study

Cited by 8 publications

References 19 publications

Change in and Long-Term Investigation of Neuro-Otologic Disorders in Disaster-Stricken Fukushima Prefecture: Retrospective Cohort Study before and after the Great East Japan Earthquake

Change in and Long-Term Investigation of Neuro-Otologic Disorders in Disaster-Stricken Fukushima Prefecture: Retrospective Cohort Study before and after the Great East Japan Earthquake

Effect of Herpes Zoster Treatment and Sudden Sensorineural Hearing Loss Using National Health Insurance Claims Data of South Korea

Role of viral infection in sudden hearing loss

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