No Increased Risk of Fetal Death or Prolonged Time to Pregnancy in Women with Psoriasis

Abstract

Serum gastrin-releasing peptide levels correlate with pruritus in patients with atopic dermatitis.

Psoriasis and adverse pregnancy outcomes: a systematic review of observational studies

“…Studies were conducted in diverse settings, including hospital and community inpatient/outpatient facilities, clinical trials, national registries or combinations thereof. The presence of psoriasis and the various pregnancy outcomes were identified using medical records and health insurance claims, with one article using a database containing self‐reported psoriasis diagnoses . The studies that stratified patients with psoriasis by severity primarily used treatment type as a surrogate marker (e.g.…”

“…Only those studies that received a rating of ‘good’ or ‘fair’ were included. Specifically, seven of the included articles were rated as ‘good’, while two were rated as ‘fair’ (any disagreements were resolved by consensus)…”

“…In fact, > 100 000 births are estimated to occur in women with psoriasis annually in the U.S.A., underscoring the importance of studying the relationship between psoriasis and pregnancy . Yet this is an area of research that is currently lacking, even although other autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) have been shown to affect adversely pregnancy outcomes . We hypothesized that the immune dysregulation occurring in psoriasis, as in other autoimmune diseases, will negatively affect the normal progression of pregnancy and result in adverse pregnancy outcomes.…”

Treating Psoriasis During Pregnancy: Safety and Efficacy of Treatments

“…In the study by Yang et al [20], mild psoriasis was not associated with an excess risk of adverse birth outcomes. In a large Danish prospective cohort study of 100,418 pregnancies with a prevalence of psoriasis of 3 %, mild to moderate psoriasis was not found to be a risk factor for fetal death after the first trimester or for prolonged time to pregnancy [23]. This is also in line with Lima et al [24], who found no increased risk of spontaneous abortions in pregnant women with psoriasis.…”

Inflammatory and glandular skin disease in pregnancy

“…14,15 Women with psoriasis are less likely to take prenatal vitamin supplementation. 14 When adjusted for the confounding variables of obesity, alcohol consumption, smoking, and maternal age of conception, a Danish-based population study found no increased risk for fetal death or maternal fecundity among psoriatic women.…”