No Improvement of Pancreas Transplant Endocrine Function by Exogenous Insulin Infusion (Islet Rest) in the Postoperative Period

Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia

“…[1][2][3] Existing strategies for the treatment of type 1 diabetes have sought to replace insulin in a physiologic way (multiple injections, insulin pump) or replacement of ␤-cell mass (islet or whole pancreas transplant). [4][5][6][7] Both approaches have limitations, hence new strategies are required for optimal treatment of hyperglycemia and prevention of complications. In particular, the autoimmune process responsible for initial complete destruction of ␤-cells in the islets of Langerhans continues to plague the use of islet transplantation.…”

A Novel Resting Strategy for Improving Islet Engraftment in the Liver

“…In support of these findings, Koh et al recently demonstrated that peritransplant infusions of insulin and heparin were positively correlated with the clinical outcome of islet transplantation (10). On the other hand, Dafoe et al (11) and Keymeulen et al (12) have shown that exogenous insulin treatment after transplantation did not improve subsequent endocrine function.…”