No improvement in male-pattern hair loss using laser hair-comb therapy: a 6-month, half-head, assessor-blinded investigation in two men

Low‐level laser therapy as a treatment for androgenetic alopecia

“…Two out of the 11 studies did not find a statistically significant increase in hair count or hair density in their subjects following LLLT Therapy. One reported no difference between areas irradiated for 6 months with the HairMax LaserComb compared to non‐irradiated regions in their case report of two males with AGA . A second study followed six females and one male using a 650 nm laser hood for 3–6 months and found an overall increase of 7.57 terminal hairs, but this value was not statistically significant .…”

“…Among them two were animal studies and two did not investigate AGA. Eleven were eventually evaluated including one case report, one case series, four cohort studies, and five RCTs .…”

“…Ten studies evaluated a total of 444 males, compared to six studies with a total of 236 females. The efficacy of the HairMax LaserComb and TOPHAT 655 were investigated in five and two studies, respectively. Other lasers studied include an LLLT hood device , application of 655 nm red light and 780 nm of infrared light , a Helmet type LLLT , and the X5 HairLaser .…”

“…Other lasers studied include an LLLT hood device , application of 655 nm red light and 780 nm of infrared light , a Helmet type LLLT , and the X5 HairLaser . Nine studies out of the 11 exclusively utilized a wavelength between 630 nm and 660 nm, with the most popular being 655 nm , while one study used a mix of 655 nm and 780 nm and another study did not specify the wavelength of the laser device . Nine out of 11 studies utilized a power setting of 5 mW or less , while one study utilized a power setting of 30–34 mW , and one did not report a power setting .…”

“…Nine studies out of the 11 exclusively utilized a wavelength between 630 nm and 660 nm, with the most popular being 655 nm , while one study used a mix of 655 nm and 780 nm and another study did not specify the wavelength of the laser device . Nine out of 11 studies utilized a power setting of 5 mW or less , while one study utilized a power setting of 30–34 mW , and one did not report a power setting . An irradiance setting of the laser device was reported in only one study with a value of 92.15 mW/cm 2 , while another studied provided the energy value of 2.9 J per session.…”