No harm from five year ingestion of oats in coeliac disease

Abstract

Background: Six to 12 months of ingestion of moderate amounts of oats does not have a harmful effect in adult patients with coeliac disease. As the safety of long term intake of oats in coeliac patients is not known, we continued our previous 6-12 month study for five years. Aim: To assess the safety of long term ingestion of oats in the diet of coeliac patients. Patients: In our previous study, the effects of a gluten free diet and a gluten free diet including oats were compared in a randomised trial involving 92 adult patients with coeliac disease (45 in the oats group, 47 in the control group). After the initial phase of 6-12 months, patients in the oats group were allowed to eat oats freely in conjunction with an otherwise gluten free diet. After five years, 35 patients in the original oats group (23 still on an oats diet) and 28 in the control group on a conventional gluten free diet were examined. Methods: Clinical and nutritional assessment, duodenal biopsies for conventional histopathology and histomorphometry, and measurement of antiendomysial, antireticulin, and antigliadin antibodies. Results: There were no significant differences between controls and those patients consuming oats with respect to duodenal villous architecture, inflammatory cell infiltration of the duodenal mucosa, or antibody titres after five years of follow up. In both groups histological and histomorphometric indexes improved equally with time.Conclusions: This study provides the first evidence of the long term safety of oats as part of a coeliac diet in adult patients with coeliac disease. It also appears that the majority of coeliac patients prefer oats in their diet.

Adult coeliac patients do tolerate large amounts of oats

“…The lack of response to oats in the present study was probably not due to a relatively small amount of the potentially active amino acids in the protein fraction. One can speculate whether the latent time before the symptoms and adverse effects occur is longer on an oat diet than on a gliadin challenge, however Finnish coeliac patients consuming oats have been followed for 5 y without any deterioration (Janatuinen et al, 2002).…”

“…Administration of oats to the gluten-free diet has only been studied for short periods of 2 weeks to 6 months, except for the 5 y follow-up of 23 of the participants in the Finnish study (Janatuinen et al, 2002).…”

Session 1: Allergic disease The challenges of managing food hypersensitivity

“…Proposed nomenclature for food hypersensitivity (1) . Proceedings of the Nutrition Society (93,94) Use of alternative grains should be individualised and based on tolerance as determined by clinician and/or dietitian Proceedings of the Nutrition Society …”

Screening for Antidepressant-Like Effect of Methanolic Seed Extract of Avena Sativa using Animal Models

“…[3] The primary chemical constituents includes saponins (Avenacosides A and B), flavonoids, starch, (trigonelline, avenine, gramine), steroids, calcium, B-vitamins, lysine, methionine and alkaloids such as gramine, they also contain iron, manganese, zinc. [4][5][6] The plant used for depression, exhaustion, stress reduction, nervous system tonic, sexual performance, detoxification, nicotine cravings, fibroids, candidiasis, attention deficit disorder, respiratory and immune support and migraine headaches. [7] There is no significant work has been carried out on the antidepressant effect of this plant extract till date.…”