No Glycemic Benefit From Guar Administration in NIDDM

Holman, Rury R.; Steemson, J; Darling, Pauline B.; Turner, R. C.

doi:10.2337/diacare.10.1.68

Cited by 40 publications

(14 citation statements)

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“…Thus, Stahl and Berger (1990) found no significant differences in glycosilated haemoglobin after the administration of 15 g of guar gum daily during 3 months; Jones et al (1985), after the administration of 10 g=day during 2 months, obtained a significant fall in GhbA 1c levels, without significant changes in 24 h urinary glucose excretion. Behall (1990) observed that guar gum significantly reduced blood C-peptide concentrations after the administration of 31.7 g fibre per day during 6 months and Holman et al (1987) obtained no significant changes in blood C-peptide and GhbA 1c concentrations after the administration of 15 g=day during 8 weeks.…”

Section: Discussionmentioning

confidence: 95%

Therapeutic effects of psyllium in type 2 diabetic patients

et al. 2002

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Objective: The aim of this study was to evaluate the effects of psyllium in type 2 diabetic patients. Design: The study included three phases: phase 1 (1 week), phase 2 (treatment, 14 g fibre=day, 6 weeks) and phase 3 (4 weeks). At the end of each phase a clinical evaluation was performed after the ingestion of a test breakfast of 1824.2 kJ (436 kcal). Measurements included concentrations of blood glucose, insulin, fructosamine, GHbA 1c , C-peptide and 24 h urinary glucose excretion. In addition, uric acid, cholesterol and several mineral and vitamin concentrations were also evaluated. Setting: The study was performed at the Department of Pharmacology, Toxicology and Nursing at the University of Leó n (Spain). Subjects: Twenty type 2 diabetic patients (12 men and 8 women) participated in the study with a mean age of 67.4 y for men and 66 y for women. The mean body mass index of men was 28.2 kg=m 2 and that of women 25.9 kg=m 2 . Results: Glucose absorption decreased significantly in the presence of psyllium (12.2%); this reduction is not associated with an important change in insulin levels (5%). GHbA 1c , C-peptide and 24 h urinary glucose excretion decreased (3.8, 14.9 and 22.5%, respectively) during the treatment with fibre (no significant differences) as well as fructosamine (10.9%, significant differences). Psyllium also reduced total and LDL cholesterol (7.7 and 9.2%, respectively, significant differences), and uric acid (10%, significant difference). Minerals and vitamins did not show important changes, except sodium that increased significantly after psyllium administration. Conclusions:The results obtained indicate a beneficial therapeutic effect of psyllium (Plantaben 1 ) in the metabolic control of type 2 diabetics as well as in lowering the risk of coronary heart disease. We also conclude that consumption of this fibre does not adversely affect either mineral or vitamin A and E concentrations. Finally, for a greater effectiveness, psyllium treatment should be individually evaluated.

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Section: Discussionmentioning

confidence: 95%

Therapeutic effects of psyllium in type 2 diabetic patients

et al. 2002

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“…Sometimes ®ber ingestion modestly improves glycaemic control (Carroll et al, 1981;Lim et al, 1990) or, although glucose tolerance is better, insulin response remains unchanged (Groop et al, 1993). In other studies the improvement of blood glucose, or decreased insulin requirements, in diabetic patients (Rivellese et al, 1980;Jones et al, 1985;Holman et al, 1987;Thomas et al, 1988;Sels et al, 1992;Groop et al, 1993) and enhanced glucose tolerance in healthy subjects could not be reproduced (Groop et al, 1986;Behall, 1990;Sels et al, 1992). These apparent discrepancies can be due to differences in dietary ®ber sources or in the composition of the diets employed, as well as to the interindividual variability in response (Chuang et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Effects of ispaghula husk and guar gum on postprandial glucose and insulin concentrations in healthy subjects

et al. 2001

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Objective: The aim of this study was to evaluate, under the same experimental conditions and in the same subjects, the effects of ispaghula husk and guar gum on postprandial glucose and insulin concentrations in healthy female subjects. Design: An oral glucose load with and without ®ber was administered in the morning after an overnight fast. The study of the ®ber effect was planned according to a randomized and cross-over design. Setting: The study was performed at the Department of Pharmacology, Toxicology and Nursing at the University of Leo Ân (Spain). Subjects: Ten healthy female volunteers aged 30 ± 48 y with normal body mass indices participated in this study. Results: A signi®cant decrease in mean serum insulin concentrations was observed from 30 to 90 min in the presence of both ®bers. The area under the insulin curve was signi®cantly reduced by 36.1% for ispaghula husk and 39.4% for guar gum. The area under the glucose curve was reduced by 11.1% (signi®cant difference) for ispaghula husk and 2.6% for guar gum (no signi®cant difference). Conclusions: According to the results obtained in this study, the administration of ispaghula husk may be bene®cial due to its ability to reduce glucose postprandial concentration and especially insulin requirements. Individualization of the treatment would be advisable due to large individual variations observed in glycemic and insulinemic postprandial responses.

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“…15,16 The efficacy of high fibre diets in the treatment of diabetes remains, controversial, [17][18][19] and, the use of purified fibre as a supplement is not advocated. 20 The present study was designed to assess the effect of a low GI diet, a high GI diet and a high fibre diet on glycaemic control and on premeal insulin requirement in well-controlled Type 1 diabetic patients on intensive insulin therapy.…”

Section: Introductionmentioning

confidence: 99%

Effects of different glycaemic index foods and dietary fibre intake on glycaemic control in Type 1 diabetic patients on intensive insulin therapy

et al. 1998

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To evaluate the influence of a low glycaemic index (GI), high GI and high fibre diet on glycaemic control and insulin requirement in Type 1 diabetic patients on intensive insulin therapy, nine well-controlled, highly-motivated Type 1 diabetic patients were put on a control diet for 12 days and then randomized in a consecutive manner to 12 days of each diet, in a crossover design. During each experimental diet, the study subjects adjusted their premeal insulin (soluble) dose to maintain their 1-h postprandial capillary glucose at or below 10 mmol l(-1). At the end of each experimental diet, they were submitted to a standardized breakfast of the diet under study, using the same premeal insulin dose as that required for the control diet. The control diet contained 16.0+/-3.0 g of fibre day(-1) with a GI of 77.4+/-2.7 compared to 15.3+/-6.3 and 66.2+/-1.2 for the low GI diet, 17.1+/-7.2 and 92.9+/-3.6 for the high GI diet, and 56.1+/-3.6 (including 15 g of guar) and 73.5+/-2.1 for the high fibre diet. Prebreakfast capillary blood glucose (6.2+/-1.2 mmol l(-1)) on the low GI diet and postbreakfast capillary blood glucose (8.7+/-1.8 mmol l(-1)) on the high fibre diet were significantly lower than the values obtained with the control diet (8.0+/-1.8 and 10.6+/-2.4, respectively; p<0.05). No change in premeal or basal insulin dose was required. During the standardized breakfasts, the incremental area under the curve was 1.6+/-1.5 mmol l(-1) min(-1) for the control diet compared to 1.1+/-1.8 for the low GI diet, 3.2+/-1.4 for the high GI diet (p<0.05 versus low GI and high fibre; p=0.08 versus control), and 1.0+/-0.9 for the high fibre diet. These observations indicate that in well-controlled Type 1 diabetic subjects on intensive insulin therapy, major alterations in the GI and fibre content of meals induce small but significant changes in glucose profile. In everyday life, however, these differences are blunted, and plasma glucose remains within the target range for optimal metabolic control.

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No Glycemic Benefit From Guar Administration in NIDDM

Cited by 40 publications

References 0 publications

Therapeutic effects of psyllium in type 2 diabetic patients

Therapeutic effects of psyllium in type 2 diabetic patients

Effects of ispaghula husk and guar gum on postprandial glucose and insulin concentrations in healthy subjects

Effects of different glycaemic index foods and dietary fibre intake on glycaemic control in Type 1 diabetic patients on intensive insulin therapy

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