No genotoxic effect in exfoliated bladder cells of rat under the exposure of 1800 and 2100 MHz radio frequency radiation

Gürbüz, Neslihan; Sirav, Bahriye; Çölbay, Mehmet; Yetkin, İlhan; Seyhan, Nesrin

doi:10.3109/15368378.2013.831354

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…RF field emitted from mobile phones has been mainly at frequencies 800-2000 MHz [Chen et al, 2005], which can induce adverse health effects, such as brain tumors [Morgan et al, 2015], infertility [La Vignera et al, 2012;Merhi, 2012;Sepehrimanesh et al, 2017], genotoxic effects [Atli et al, 2013;Duan et al, 2015], fatigue, rapid exhaustibility [Schoeni et al, 2015], increased anxiety, poor learning [Saikhedkar et al, 2014], and so on. Meanwhile, other studies showed beneficial effects or no effects of RF field on biological tissue [Kismali et al, 2012;Ahlers and Ammerm€ uller, 2014;Gurbuz et al, 2014]. A systematic review in 2012 [La Vignera et al, 2012] found that although RF field was discussed in a lot of published literature, not much literature described the impact of RF field produced by mobile phones on bone microstructure and metabolism, especially in-vivo experiments.…”

Section: Introductionmentioning

confidence: 99%

Effects of 1.8 GHz radiofrequency field on microstructure and bone metabolism of femur in mice

Guo

Zhang

et al. 2018

Bioelectromagnetics

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To investigate the effects of 1.8 GHz radiofrequency (RF) field on bone microstructure and metabolism of femur in mice, C57BL/6 mice (male, age 4 weeks) were whole-body exposed or sham exposed to 1.8 GHz RF field. Specific absorption rates of whole body and bone were approximately 2.70 and 1.14 W/kg (6 h/day for 28 days). After exposure, microstructure and morphology of femur were observed by microcomputed tomography (micro-CT), Hematoxylin and Eosin (HE) and Masson staining. Subsequently, bone parameters were calculated directly from the reconstructed images, including structure model index, bone mineral density, trabecular bone volume/total volume, connectivity density, trabecular number, trabecular thickness, and trabecular separation. Biomarkers that reflect bone metabolism, such as serum total alkaline phosphatase (ALP), bone-specific alkaline phosphatase (BALP), and tartrate-resistant acid phosphatase 5b (TRACP-5b), were determined by biochemical assay methods. Micro-CT and histology results showed that there was no significant change in bone microstructure and the above parameters in RF group, compared with sham group. The activity of serum ALP and BALP increased 29.47% and 16.82%, respectively, in RF group, compared with sham group (P < 0.05). In addition, there were no significant differences in the activity of serum TRACP-5b between RF group and sham group. In brief, under present experimental conditions, we did not find support for an effect of 1.8 GHz RF field on bone microstructure; however, it might promote metabolic function of osteoblasts in mice. Bioelectromagnetics. 39:386-393, 2018. © 2018 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 99%

Effects of 1.8 GHz radiofrequency field on microstructure and bone metabolism of femur in mice

Guo

Zhang

et al. 2018

Bioelectromagnetics

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“…The conclusions from five different experiments, employing three different concentrations of MMC, were that a) RFR exposure alone, at moderate power levels which resulted in a temperature increase in the cell culture medium of less than 3 degrees C, is not mutagenic; and b) when cells are simultaneously treated with MMC and RFR at these same moderate power levels, the RFR does not affect either the inhibition of cell growth or the extent of mutagenesis resulting from the treatment with the chemical MMC alone (51). We have two reports which show no statistically significant difference between 1800 MHz and 2100 MHz RFR exposed groups with respect to nonexposed groups (52,53).…”

Section: Radiofrequency Radiation Exposure 90mentioning

confidence: 75%

Genotoxic Studies Performed After Radiofrequency Radiation Exposure

Gürbüz

Sirav²,

Seyhan³

2018

GMJ

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Objective: With the development of technology human beings are increasingly under the exposure of electromagnetic fields, mainly radiofrequency radiation (RFR) from wireless technologies, mobile phones, base stations etc. There are many genotoxic effects, i.e. DNA and chromosome change studies related RFR exposures. There is still some uncertainty, no definitive conclusions have been reached so far. The aim of present study is to evaluate the genotoxicity studies about RFR exposure reported from 1989 to 2016. Methods: The PubMed database from 1989 to 2016 was searched for "radiofrequency radiation" and "genotoxicity tests". Genotoxicity studies performed under RFR exposure were selected and classified as reported significant effects and reported no significant effect. Results: There were 53 genotoxic effects of RFR studies totally and 19 of them indicated genotoxic effects (35,8 %) and 34 of total studies reported no significant effect (64,2 %). Conclusion: It is apparent that there is no consistent pattern that RFR exposure could induce genetic damages. However, one can conclude that under certain conditions of exposure, RFR could be genotoxic. Generally the genotoxic effect of short-term exposure to RFR have been studied up to date. Long-term exposure to RFR is increasing in the environment. So, long-term effect of repeated exposure to RFR should also be studied by taking into consideration the DNA repair processes in order to identify the biological mechanisms involved.

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“…In a different study, it was reported that 1800 and 2100 MHz EMF radiation had no effect on exfoliated bladder cells in rats. [31] However, 3G mobile phone radiation at 2100 MHz was found to induce many histopathological changes in parotid gland of rats, but no nuclear changes were observed. [32] There are no previously published studies in the literature on the effects of a 2100 MHz EMF on fracture healing in the maxillofacial region.…”

Section: Histopathological Analysismentioning

confidence: 99%

Effect of 2100 MHz mobile phone radiation on healing of mandibular fractures: an experimental study in rabbits

Durğun

Daşdağ

Erbatur

et al. 2015

Biotechnology & Biotechnological Equipment

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Fractures in the maxillofacial region are among the most frequent incidences in patients exposed to trauma. The aim of this study was to evaluate the effect of 2100 MHz electromagnetic radiation on the healing of mandibular fractures in rabbits. The study was carried out on 12 mature male New Zealand rabbits. After producing a left mandibular osteotomy, the fracture was repaired by using a plate screw. The rabbits were divided into two groups À control and experimental. The experimental group was exposed for 3 h daily to a 2100 MHz radiofrequency (RF) for 28 d. Biomechanical, histopathological and radiological tests were performed during the healing of the mandibular bone. According to the biomechanical tests, the energy absorption capacity, toughness and maximum strength of the mandibular bone were increased compared to the control group (6.84 vs. 2.57, 0.135 vs. 0.041 and 22.21 vs. 10.32, respectively). No significant differences between the two groups were found during the radiological assessment. However, the histopathological examination revealed that the fracture healing score was higher in the experimental group when compared to the control group (8.0 vs. 2.75, respectively). In conclusion, the results of this study showed that a 2100 MHz RF radiation positively affected fracture healing.

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No genotoxic effect in exfoliated bladder cells of rat under the exposure of 1800 and 2100 MHz radio frequency radiation

Cited by 5 publications

References 25 publications

Effects of 1.8 GHz radiofrequency field on microstructure and bone metabolism of femur in mice

Effects of 1.8 GHz radiofrequency field on microstructure and bone metabolism of femur in mice

Genotoxic Studies Performed After Radiofrequency Radiation Exposure

Effect of 2100 MHz mobile phone radiation on healing of mandibular fractures: an experimental study in rabbits

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