Abstract:Currently, xenogeneic extracorporeal liver perfusion is used in the treatment of acute liver failure. In order to determine whether transgeneity for human regulatory proteins could improve the functional outcome of the ex‐vivo liver in relation to the histopathological changes, we studied the effect of the humoral mechanism in xenogeneic isolated rat liver perfusion in normal and transgenic rat livers. Isolated rat liver perfusion was performed for 2 h in normal rat livers with Krebs Henseleit (KH) and human s… Show more
“…Similar data were generated by Luo et al [26]. In another model, a more limited human complement activation and hepatocellular damage in organs transgenic for hDAF did not give rise to any change in liver function [27]. There was no significant difference between group A (xenoperfused hDAF liver) and group B (xenoperfused wild-type liver), or between group C (alloperfused wild-type liver) and group B (xenoperfused wild-type liver).…”
In our study, rat livers transgenic for hDAF were better protected against early tissue damage by perfusion with human blood, but this did not result in a longer xenograft survival.
“…Similar data were generated by Luo et al [26]. In another model, a more limited human complement activation and hepatocellular damage in organs transgenic for hDAF did not give rise to any change in liver function [27]. There was no significant difference between group A (xenoperfused hDAF liver) and group B (xenoperfused wild-type liver), or between group C (alloperfused wild-type liver) and group B (xenoperfused wild-type liver).…”
In our study, rat livers transgenic for hDAF were better protected against early tissue damage by perfusion with human blood, but this did not result in a longer xenograft survival.
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