No excess risk of colorectal cancer among alcoholics followed for up to 25 years

Ye, W; Romelsjö, Anders; Augustsson, Katarina; Adami, Hans‐Olov; Nyrén, Olof

doi:10.1038/sj.bjc.6600846

Cited by 6 publications

(4 citation statements)

References 32 publications

(25 reference statements)

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“…In other study, alcohol intake was not associated with colon cancer risk. 18 These reports have not been inconclusive in the association between development of adenoma and alcohol intake until now.…”

Section: Discussionmentioning

confidence: 98%

Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas

et al. 2015

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Background/AimsAge, sex, gene and life style are modulating risks for colon cancer. Although alcohol intake may impact on colorectal adenoma, clear association has not been established yet. We aimed to investigate effects of alcohol consumption on the characteristics of colorectal adenoma.MethodsPatients who underwent colonoscopic polypectomy of colorectal adenoma in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The alcohol drinking patients were subdivided into normal or abnormal laboratory group, and alcoholic liver diseases group.Results212 patients with colorectal adenoma were analyzed; advanced adenoma and multiple adenoma were found in 68 (32.0%) and 79 (37.2%) patients. When compared to the nondrinker group (120/212 patients), the alcohol drinker group (92/212 patients) represented significantly high odds ratios (ORs) for advanced adenoma (OR, 2.697; P=0.002), and multiple adenoma (OR, 1.929; P=0.039). Among alcohol drinker (92 patients), the ORs of advanced adenoma were 6.407 (P=0.003) in alcoholic liver diseases group (17 patients), 3.711 (P=0.002) in the alcohol drinker with abnormal lab (24 patients), and 2.184 (P=0.034), in the alcohol drinker with normal lab (51 patients) compared to nondrinker group.ConclusionsThis study showed that alcohol drinking may influence on the development of advanced colorectal adenoma and multiplicity. Especially in the group with alcoholic liver diseases and with abnormal lab presented significantly higher ORs of advanced adenoma.

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Section: Discussionmentioning

confidence: 98%

Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas

et al. 2015

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“…Alcohol consumption in relation to CRC risk remains controversial, with some studies reporting a positive association (86)(87)(88), whereas others do not (89,90). Jacobson et al (91) reported that there was no association found between alcohol intake and adenoma recurrence in a case-control study comparing 186 recurrent polyp cases with 330 controls.…”

Section: Alcoholmentioning

confidence: 96%

Colorectal Cancer and the Relationship Between Genes and the Environment

Heavey¹,

McKenna²,

Rowland³

2004

Nutrition and Cancer

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Colorectal cancer (CRC) is a significant cause of morbidity and mortality in developed countries, with both genetic and environmental factors contributing to the etiology and progression of the disease. Several risk factors have been identified, including positive family history, red meat intake, smoking, and alcohol intake. Protective factors include vegetables, calcium, hormone replacement therapy, folate, nonsteroidal anti-inflammatory drugs, and physical activity. The interaction between these environmental factors, in particular diet and genes, is an area of growing interest. Currently, oncogenes, tumor suppressor genes, and mismatch repair genes are believed to play an essential role in colorectal carcinogenesis. When considering the genetics of CRC, only 10% of cases are inherited and only 2-6% can be ascribed to the highly penetrant genes, such as APC, hMLH and hMSH2. Lower penetrance genes combined with a Western-style diet contribute to the majority of sporadic CRCs. The purpose of this article is to give a brief overview of the epidemiologic studies that have been conducted and present the major findings. Here, we examine the molecular events in CRC, with particular focus on the interaction between genes and environment, and review the most current research in this area.

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“…14,15 The association between alcohol consumption and colorectal cancer is not conclusive, as some reports have shown an increased risk and others no excess risk. [16][17][18][19][20] Given the possible association between alcohol consumption and colorectal cancer, polymorphisms in the XRCC1 gene, which have the potential to alter the structure of DNA repair enzyme, could affect the risk of colorectal cancer in alcohol drinkers.We conducted a hospital-based case-control study of colorectal cancer in Incheon, South Korea, where the age-adjusted incidence rates were 27.0 among men and 17.5 among women per 100,000 person-years during the period 1997-2000. 2 To elucidate the role of the XRCC1 gene polymorphisms in colorectal cancer development, we carried out genotype association analyses.…”

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confidence: 99%

Polymorphisms of XRCC1 gene, alcohol consumption and colorectal cancer

Hong

Lee

Kim

et al. 2005

Intl Journal of Cancer

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To evaluate contribution of polymorphisms of the XRCC1 gene to the risk of colorectal cancer, we conducted a case-control study of 209 colorectal cancer cases and 209 age-and gender-matched controls in the Korean population. We tested the hypothesis by constructing allele combinations with known SNP. Allelic variants of the XRCC1 gene at codons 194, 280 and 399 were analyzed in lymphocyte DNA by PCR-RFLP. We observed an increased risk of colorectal cancer associated with the 399Gln allele. The odds ratio (OR) was 1.61 (95% confidence interval [CI] 1.09-2.39) for the 399Gln allele. When combined allele-specific OR were calculated after estimating frequencies, 3 common allele combinations were found to be associated with an increased risk of colorectal cancer. The OR for the 194Trp-280Arg-399Arg was 1.48 (95% CI 5 1.06-2.07) using 194Arg-280Arg-399Arg as the reference. The OR for the 194Arg-280His-399Arg and the 194Arg-280Arg-399Gln were 1.78 (95% CI 5 1.09-2.89) and 1.78 (95% CI 5 1.23-2.59), respectively. Analysis after controlling for smoking, exercise and dietary habits indicated that alcohol consumption ( 80 g/week) is a significant risk factor of colorectal cancer (OR 5 2.60, 95% CI 5 1. 46-4.62). An increased risk for colorectal cancer was identified in alcohol drinkers with the risky allele combinations. Our results suggest that polymorphisms in the XRCC1 genes may contribute to colorectal cancer susceptibility, and some evidence was obtained of a genetic modification for the relationship between alcohol intake and colorectal cancer. ' 2005 Wiley-Liss, Inc.Key words: polymorphisms; XRCC1; genotype; allele; colorectal cancer; alcohol Colorectal cancer is one of the most commonly diagnosed cancers in North America and Western Europe, 1 and is the fourth most common cause of cancer in South Korea. 2 Inherited deficiencies in DNA repair have been associated with an individual's susceptibility to cancer. 3 Therefore, polymorphisms of DNA repair genes may increase the risk of colorectal cancer.The human XRCC1 gene, one of the DNA repair genes, was identified because of its ability to restore DNA repair activity in a Chinese hamster ovary mutant cell line EM9. 4 The XRCC1 protein is involved in base-excision repair, and interacts with DNA ligase III, DNA polymerase b, poly(ADP-ribose)polymerase (PARP), polynucleotide kinase and AP endonuclease I. 5-8 The base-excision repair pathway is designed to remove non-bulky base adducts, which are produced by methylation, oxidation or reduction by ionizing radiation or oxidative damage. 9,10 Three coding polymorphisms of the DNA repair gene XRCC1 (Arg194Trp, Arg280His and Arg399Gln) have been identified in man, suggesting altered efficiency due to amino acid substitutions. 11,12 Alcohol consumption has been associated with the production of reactive oxygen species, which are known to cause DNA lesions that can be removed by the DNA base-excision repair pathway. 13 Meta-analyses of alcohol consumption in relation to colorectal cancer have reported a small or moderate addit...

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No excess risk of colorectal cancer among alcoholics followed for up to 25 years

Cited by 6 publications

References 32 publications

Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas

Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas

Colorectal Cancer and the Relationship Between Genes and the Environment

Polymorphisms of XRCC1 gene, alcohol consumption and colorectal cancer

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