No Evidence of Spumaretrovirus Infection Markers in 19 Cases of De Quervain's Thyroiditis

Debons-Guillemin, M.C.; Valla, Jocelyne; Gazeau, Jean; Wybier-Franqui, Janine; Giron, Marie-Lou; Toubert, Marie‐Elisabeth; Canivet, M; Périès, J.

doi:10.1089/aid.1992.8.1547

Cited by 24 publications

(8 citation statements)

References 2 publications

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“…This group was also found by Lagaye et al [11] and termed as 'a subject who contains only one or more subgenomic HFV sequences'. However, our results differed from previous studies [4,5,10,11,21] in that we found that some HFVrelated sequences are also present in the genome of some healthy subjects.…”

Section: Resultscontrasting

confidence: 99%

“…HFV has been noted as a good candidate for the causative agent of GD based on several observations [5,11,27]. However, due to the lack of reproducible results, the role of HFV in the etiology of GD has never been clear.…”

Section: Discussionmentioning

confidence: 99%

“…HFV has been linked to several pathological disorders, most particularly to human thyroiditis disorders such as subacute de Quervain's thyroiditis [5,22,26] and Graves' disease (GD) [4,10]. However, the association of HFV with the etiology of the diseases has been an issue of debate, since the results of several studies have been inconsistent.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Human Foamy Virus-Related Sequences in the Korean Population

et al. 1998

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The possible association of human foamy virus (HFV) with human thyroid disorders such as Graves’ disease (GD) has been a topic of controversy due to the inconsistent results reported by several groups of investigators. Here we report the investigation of the presence of HFV-related sequences in the Korean population. DNA was obtained from peripheral blood lymphocytes from 24 GD patients and 23 healthy blood donors and subjected to PCR amplification using three sets of nested primers derived from gag, env, and LTR regions of the HFV genome. Contrary to previously reported studies, our analysis identified HFV-related sequences in the genomes of both healthy individuals and the GD patients. However, the nature of the HFV genome present in each group appeared to be different. We detected all 3 regions of HFV-related sequences in 29% of the HFV-positive GD patients, while no samples in the control group amplified all three regions. This suggests that the LTR may be used as a tool for screening for HFV in GD patients. Our data favor the hypothesis of a relationship between GD and the presence of HFV-related sequences, though in a complex way.

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Section: Resultscontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence of Human Foamy Virus-Related Sequences in the Korean Population

et al. 1998

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“…Subsequently, the agent was reanalyzed by immunofluorescence and electron microscopy and reclassified as an FV (119). A more comprehensive study using IFA, radioimmunoprecipitation (RIPA), Western blot (WB), and enzymelinked immunoabsorbent assay (ELISA) on samples from 19 patients demonstrated no association between FV infection and thyroiditis de Quervain (26). As part of a larger study investigating the prevalence of FV infection in humans, 59 patients with thyroid disorders, including 28 with Quervain's thyroiditis, were analyzed by IFA, RIPA, WB, and PCR (103).…”

Section: Thyroiditis De Quervainmentioning

confidence: 99%

Historical Perspective of Foamy Virus Epidemiology and Infection

2001

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Foamy viruses (FV) are complex retroviruses which are widespread in many species. Despite being discovered over 40 years ago, FV are among the least well characterized retroviruses. The replication of these viruses is different in many interesting respects from that of all other retroviruses. Infection of natural hosts by FV leads to a lifelong persistent infection, without any evidence of pathology. A large number of studies have looked at the prevalence of primate foamy viruses in the human population. Many of these studies have suggested that FV infections are prevalent in some human populations and are associated with specific diseases. More recent data, using more rigorous criteria for the presence of viruses, have not confirmed these studies. Thus, while FV are ubiquitous in all nonhuman primates, they are only acquired as rare zoonotic infections in humans. In this communication, we briefly discuss the current status of FV research and review the history of FV epidemiology, as well as the lack of pathogenicity in natural, experimental, and zoonotic infections

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“…Subsequently, the agent was reanalyzed by immunofluorescence and electron microscopy and was reclassified as a foamy virus [ 17 ]. However, the implication of foamy virus has not been confirmed: a more comprehensive study using different techniques demonstrated no association between foamy-virus infection and thyroiditis in 19 patients [ 18 ]. Moreover the expression of HFV gag proteins had not been found by indirect immunofluorescence [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Viruses and thyroiditis: an update

Desailloud

Hober

2009

Virol J

385

326

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Viral infections are frequently cited as a major environmental factor involved in subacute thyroiditis and autoimmune thyroid diseases This review examines the data related to the role of viruses in the development of thyroiditis.Our research has been focused on human data. We have reviewed virological data for each type of thyroiditis at different levels of evidence; epidemiological data, serological data or research on circulating viruses, direct evidence of thyroid tissue infection. Interpretation of epidemiological and serological data must be cautious as they don't prove that this pathogen is responsible for the disease. However, direct evidence of the presence of viruses or their components in the organ are available for retroviruses (HFV) and mumps in subacute thyroiditis, for retroviruses (HTLV-1, HFV, HIV and SV40) in Graves's disease and for HTLV-1, enterovirus, rubella, mumps virus, HSV, EBV and parvovirus in Hashimoto's thyroiditis. However, it remains to determine whether they are responsible for thyroid diseases or whether they are just innocent bystanders. Further studies are needed to clarify the relationship between viruses and thyroid diseases, in order to develop new strategies for prevention and/or treatment.

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No Evidence of Spumaretrovirus Infection Markers in 19 Cases of De Quervain's Thyroiditis

Cited by 24 publications

References 2 publications

Prevalence of Human Foamy Virus-Related Sequences in the Korean Population

Prevalence of Human Foamy Virus-Related Sequences in the Korean Population

Historical Perspective of Foamy Virus Epidemiology and Infection

Viruses and thyroiditis: an update

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