No evidence of persistent mumps virus infection in inflammatory bowel disease

Iizuka, Masahiro; Saitoh, Hiroyuki; Yukawa, Michihiro; Itou, Hiroaki; Shirasaka, Tomoyuki; Chiba, Mitsuro; Watanabe, Sumio

doi:10.1016/s0016-5085(00)81258-5

Cited by 5 publications

(5 citation statements)

References 17 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Investigations into a causal link between persistent mumps virus infection and IBD using anti‐mumps IgG EIA and RT‐PCR analysis reported no evidence of an association between mumps virus and CD . Our meta‐analysis of four comparison dataset of two studies provide some suggestion that mumps virus may be associated with a protective effect from CD (RR 0.922, 95% CI 0.838 to 1.016), although this did not reach statistical significance (Figure ).…”

Section: Measles Mumps and Rubellamentioning

confidence: 64%

Current knowledge and systematic review of viruses associated with Crohn's disease

Wagner

Sim

Lee

et al. 2012

Reviews in Medical Virology

View full text Add to dashboard Cite

The aetiology of Crohn's disease (CD) is currently unknown. A viral trigger was proposed more than 40 years ago and has been the focus of many investigations. We summarised the current literature surrounding the association between viruses and CD and conducted a systematic review of all studies investigating this association quantitatively. Studies were identified by searching for 13 specific virus names or the general term 'virus' and 'Crohn's disease' in search engines PubMed and OVID. A total of 1315 studies were identified, of which 78 studies had a laboratory result. Of the 78, 46 case-control studies met all the inclusion criteria for forest plot analysis. The most common viruses studied were EBV, CMV and measles virus (MV). Forest plot analysis for each virus was carried out (fitted using random effects) and identified evidence of an association between CD and CMV (risk ratio [RR] 1.602, 95% confidence interval [CI] 1.069 to 2.400) with some suggestion that EBV may also be associated with CD (RR 1.366, 95% CI 0.996 to 1.873). However, there was evidence of large heterogeneity in the results from the identified studies for EBV. There was little evidence of an association with CD for MV, human herpes virus 6, human herpes virus 8, human simplex virus, varicella-zoster virus, mumps virus, Rubella virus, rotavirus, norovirus and adenovirus. There is still some question around whether CD is associated with the presence of a currently known virus.

show abstract

Section: Measles Mumps and Rubellamentioning

confidence: 64%

Current knowledge and systematic review of viruses associated with Crohn's disease

Wagner

Sim

Lee

et al. 2012

Reviews in Medical Virology

View full text Add to dashboard Cite

show abstract

“…Although some identified a higher IBD risk [91,92] , viral parts were not isolated from intestinal tissue [93] and the direct link with IBD could not be established. While it was suggested that the immunological response to the virus might be involved in the process of IBD presentation, as was observed with the measles virus, no concluding evidence was found [94] .…”

Section: Mumps (Parotiditis)mentioning

confidence: 99%

Pathogenesis of Crohn’s disease: Bug or no bug

Bosca-Watts

Tosca

Antón

et al. 2015

WJGP

View full text Add to dashboard Cite

“…However, the differences between the mean antibody titers of the controls and the subjects were only one or two dilutions. Recent work using reverse transcription-PCR (RT-PCR) has demonstrated no evidence of mumps virus P or HN genes in patients with inflammatory bowel disease (168). There does not yet appear to be a clear link established between HPIV and inflammatory or connective tissue disease.…”

Section: Clinical Syndromesmentioning

confidence: 99%

Parainfluenza Viruses

2003

View full text Add to dashboard Cite

Human parainfluenza viruses (HPIV) were first discovered in the late 1950s. Over the last decade, considerable knowledge about their molecular structure and function has been accumulated. This has led to significant changes in both the nomenclature and taxonomic relationships of these viruses. HPIV is genetically and antigenically divided into types 1 to 4. Further major subtypes of HPIV-4 (A and B) and subgroups/genotypes of HPIV-1 and HPIV-3 have been described. HPIV-1 to HPIV-3 are major causes of lower respiratory infections in infants, young children, the immunocompromised, the chronically ill, and the elderly. Each subtype can cause somewhat unique clinical diseases in different hosts. HPIV are enveloped and of medium size (150 to 250 nm), and their RNA genome is in the negative sense. These viruses belong to the Paramyxoviridae family, one of the largest and most rapidly growing groups of viruses causing significant human and veterinary disease. HPIV are closely related to recently discovered megamyxoviruses (Hendra and Nipah viruses) and metapneumovirus

show abstract

No evidence of persistent mumps virus infection in inflammatory bowel disease

Cited by 5 publications

References 17 publications

Current knowledge and systematic review of viruses associated with Crohn's disease

Current knowledge and systematic review of viruses associated with Crohn's disease

Pathogenesis of Crohn’s disease: Bug or no bug

Parainfluenza Viruses

Contact Info

Product

Resources

About