No evidence of HPV DNA in esophageal squamous cell carcinoma in a population of Southern Brazil

Antunes, Luciana da Conceição; Prolla, João Carlos; Lopes, Antonio de Barros; Rocha, Marta Pires da; Fagundes, Renato Borges

doi:10.3748/wjg.v19.i39.6598

Cited by 15 publications

(20 citation statements)

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“…Furthermore, in non-cancer volunteers, the HPV frequency of 13.8% was similar to the first Brazilian study carried out with samples from South of the country which found an HPV prevalence of 10% in normal esophageal samples by hybrid capture methodology 39. However, all other Brazilian studies did not detect DNA HPV in healthy esophageal samples analyzed 37, 38, 40, and this confirms unequivocally that the frequency of HPV in neoplastic and normal esophageal tissues are so variable, not only for any regional differences, but also very important, according to the methodological techniques used to address this goal 35, 36.…”

Section: Discussionsupporting

confidence: 83%

The Relation of HPV Infection and Expression of p53 and p16 Proteins in Esophageal Squamous Cells Carcinoma

et al. 2017

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GOAL: To investigate the HPV prevalence and characterize the expression of potential molecular surrogate markers of HPV infection in esophageal squamous cell carcinoma.MATERIALS AND METHODS: The prevalence of HPV in individuals with and without esophageal cancer (EC) was determined by using multiplex PCR; p16 and p53 protein levels were assessed by immunohistochemistry (IHC).RESULTS: High-risk HPV (hr-HPV) was found in the same frequency (13.8%) in esophageal squamous cell carcinoma (ESCC) and in healthy individuals. The p53 expression was positive in 67.5% of tumor tissue, 20.0% of adjacent non-tumoral tissue and 1.8% of normal esophageal tissue. p16 was positive in 11.6% of esophageal cancer cases and 4.7% of adjacent non-tumoral tissue. p16 was undetectable among control group samples. p53 and p16 levels were not significantly associated with the HPV status.CONCLUSIONS: These results suggest that hr-HPV types are not associated with the development of ESCC and that p53 and p16 protein expression have no relationship with HPV infection in normal or cancerous esophagus.

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Section: Discussionsupporting

confidence: 83%

The Relation of HPV Infection and Expression of p53 and p16 Proteins in Esophageal Squamous Cells Carcinoma

et al. 2017

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“…In addition, we observed low HPV prevalence in patients with esophageal cancer of the ESCC group (6/37, 16.3%). These results agree with those reported by Brazilian studies in which frequencies reached 15% [41][42][43][44] , and with a recent study from our group that identi ed a frequency of 13.8% using the same methodology, in patients with esophageal squamous cell carcinoma 34,45 .…”

Section: Discussionsupporting

confidence: 93%

Frequency of HPV detection in chagasic megaesophagus associated or not with esophageal squamous cell carcinoma

Munari

Sichero

Cruvinel-Carloni

et al. 2020

Preprint

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Abstract Background: Chagasic megaesophagus (clinical manifestation of chagasic disease) has been reported as an etiological factor for squamous cell carcinoma of the esophagus, as well as the presence of human papillomavirus (HPV). Objective: We accessed the prevalence of HPV DNA in a series of squamous cell carcinomas of the esophagus associated or not with the chagasic megaesophagus, and within samples of chagasic megaesophagus without cancer. Data obtained was further correlated to the pathological clinical data of affected individuals. Methods: Retrospective study that used a total 92 samples tissue/biopsy specimens of formalin fixed and paraffin embedded tissues were retrospectively collected from the southeast region of Brazil from patients treated in three hospitals: Barretos Cancer Hospital, Barretos, São Paulo; Federal University of Triângulo Mineiro (UFTM), Uberaba, Minas Gerais; and São Paulo State University (UNESP), Botucatu, São Paulo. Cases were divided in three groups: i) 24 patients with chagasic megaesophagus associated with esophageal ESCC (CM/ESCC); ii) 37 patients with esophageal ESCC without chagasic megaesophagus (ESCC); iii) 31 patients with chagasic megaesophagus without esophageal ESCC (CM). Results: We detected a higher prevalence of high-risk HPVs in patients from both CM (12/31, 38.8%) and CM/ESCC groups (8/24, 33.3%), as compared to individuals of the ESCC group (6/37, 16.3%), although data was not statistically significant. We further observed that HPV-16 was more prevalent in patients of the ESCC (4/9, 44.5%) and CM/ESCC groups (2/8, 25.0%). In addition, some of these samples presented infection by multiple HPV types. High-risk HPVs detected were HPV-31, 45, 51, 53, 56, 66, and 73, of which the majority was identified in patients from the CM group. Furthermore, low-risk HPV-11 and HPV70 were identified in individuals from both ESCC and CM groups. Conclusion: This is the first report regarding the presence of HPV DNA in megaesophagus associated with esophageal squamous cell carcinoma. In the present study, HPV infection appears to be directly related to the development of esophageal squamous cell carcinoma in patients with chagasic megaesophagus. Further studies are warrantee to confirm and better understand the role of oncogenic HPV persistent infection in these patients.

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“…They failed to find a strong association for HPV and ESCC. In the same way, Antunes and coworkers found no evidence of HPV DNA in 52 ESCC patients (Antunes, Prolla, de Barros Lopes, da Rocha, & Fagundes, ). While Cao et al () reported that 25 (86.2%) of the 29 HPV‐positive ESCCs were p16 INK4A overexpressed, other studies showed a poor association between p16 INK4a overexpression and HPV status in ESCC, so that it has been proposed as an unreliable biomarker of HPV status in ESCC patients (Michaelsen et al, ).…”

Section: Esophageal Cancermentioning

confidence: 81%

Role of viruses in gastrointestinal cancer

Mirzaei¹,

Goudarzi²,

Eslami³

et al. 2017

Journal Cellular Physiology

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Gastrointestinal cancers are a global public health problem, which represent a vast majority of all cancer‐caused deaths in both men and women. On the other hand, viral pathogens have been long implicated as etiological factors in the onset of certain human cancers, including gastrointestinal tumors. In this regard, Human Papilloma Virus (HPV), Epstein‐Barr Virus (EBV), and John Cunningham Virus (JCV) have been more strongly suggested to be involved in gastrointestinal carcinogenesis; so that, the association of HPV with oropharyngeal and anal cancers and also the association of EBV with gastric cancer have been etiologically confirmed by epidemiological and experimental investigations. Although, the association of other viruses is less evident, but may rely on co‐factors for their oncogenic roles. Therefore, to improve the prevention and treatment of these classes of cancer, their association with viral agents as potential risk factors should be investigated with care. In this respect, the present review has focused on the existing literature on the subject of viral involvement in gastrointestinal tumorgenesis, by covering and discussing various gastrointestinal cancers, corresponding viral agents and their oncogenic aspects and then summarizing evidences either supporting or rejecting a causal role of these pathogens in gastrointestinal malignancies.

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No evidence of HPV DNA in esophageal squamous cell carcinoma in a population of Southern Brazil

Abstract: There was no evidence of HPV infection in different ESCC from southern Brazil.

Cited by 15 publications

References 0 publications

The Relation of HPV Infection and Expression of p53 and p16 Proteins in Esophageal Squamous Cells Carcinoma

The Relation of HPV Infection and Expression of p53 and p16 Proteins in Esophageal Squamous Cells Carcinoma

Frequency of HPV detection in chagasic megaesophagus associated or not with esophageal squamous cell carcinoma

Role of viruses in gastrointestinal cancer

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