No evidence of genetic causal association between sex hormone-related traits and systemic lupus erythematosus: A two-sample Mendelian randomization study

Yuan, Guo-Lian; Yang, Mingyi; Xie, Jiale; Xu, Ke; Zhang, Feng

doi:10.1007/s10067-023-06700-x

Cited by 2 publications

(1 citation statement)

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“…They also noted that the existence of a causal relationship has not been adequately demonstrated due to susceptibility to unmeasured confounders. Indeed, while previous epidemiological studies have demonstrated strong associations between various risk factors and diseases, subsequent research has revealed that these associations are often the result of interference from residual confounders rather than direct causation.Some typical examples include sex hormone-related traits, systemic lupus erythematosus (SLE), and vitamin D and digestive cancers [12][13] . With the recent increase in the availability of genome-wide association study (GWAS) databases, Mendelian randomization (MR) has utilized genetic variants strongly correlated with exposure factors as instrumental variables to evaluate causal relationships between exposure factors and outcomes.…”

Section: Introductionmentioning

confidence: 99%

Age-related hearing loss and dementia risk causality: two-way Mendelian randomization analysis

Tian,

Leng,

Wang

et al. 2024

Preprint

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In response to the ongoing debate in clinical studies about the relationship between age-related hearing impairment and dementia, a two-sample Mendelian randomization (MR) study using a genome-wide association study (GWAS) database was conducted to elucidate the genetic effects of age-related hearing loss on four types of dementia (dementia, vascular dementia, and Parkinson's dementia，Alzheimer's disease).MR analyzed data from two independent sources on age-related hearing loss (exposure) and four dementias (outcome). We used the inverse variance weighting (IVW) method, the MR Egger method, and the weighted median (WM) method to investigate the impact of age-related hearing loss on dementia.In addition, we analyzed heterogeneity, horizontal diversity, and stability through Cochran's Q-test, MR-Egger intercept, and leave-one-out sensitivity analysis, respectively.Age-related hearing loss was associated with dementia (OR=1.054, 95% CI:0.633-1.754, P=0.840), vascular dementia (OR=1.985, 95% CI:0.550-7.169), P=0.295), Parkinson's dementia (OR=2.263, 95% CI:0.235-21.774, P=0.480), andAlzheimer's disease (OR=1.001, 95% CI:0.999-1.004, P=0.392), but no causal effect was found.The results of our study indicate that there is no statistically significant responsible association between age-related hearing loss and any of the four dementias, in accordance to our two-sample MR analysis.

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Section: Introductionmentioning

confidence: 99%