No evidence of chikungunya virus and antibodies shortly before the outbreak on Sri Lanka

Panning, Marcus; Wichmann, Dominic; Grywna, Klaus; Annan, Augustina; Wijesinghe, Sriyal; Kularatne, S.A.M.; Drosten, Christian

doi:10.1007/s00430-009-0110-0

Cited by 14 publications

(13 citation statements)

References 19 publications

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“…The small (5.0%) proportion of patients with serologic evidence of acute or past CHIKV infection compared with that of DENV (54%) [7] suggests the more recent emergence of CHIKV in southern Sri Lanka, and is consistent with a retrospective serosurvey conducted in Sri Lanka’s Central Province [18]. The finding that most (26/28) acute infections were associated with seroconversion and that all but one patient was ≥18 years old also suggests a population lacking immunity to CHIKV.…”

Section: Discussionsupporting

confidence: 59%

Chikungunya as a Cause of Acute Febrile Illness in Southern Sri Lanka

et al. 2013

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BackgroundChikungunya virus (CHIKV) re-emerged in Sri Lanka in late 2006 after a 40-year hiatus. We sought to identify and characterize acute chikungunya infection (CHIK) in patients presenting with acute undifferentiated febrile illness in unstudied rural and semi-urban southern Sri Lanka in 2007. Methodology/Principal FindingsWe enrolled febrile patients ≥ 2 years of age, collected uniform epidemiologic and clinical data, and obtained serum samples for serology, virus isolation, and real-time reverse-transcriptase PCR (RT-PCR). Serology on paired acute and convalescent samples identified acute chikungunya infection in 3.5% (28/797) patients without acute dengue virus (DENV) infection, 64.3% (18/28) of which were confirmed by viral isolation and/or real-time RT-PCR. No CHIKV/DENV co-infections were detected among 54 patients with confirmed acute DENV. Sequencing of the E1 coding region of six temporally distinct CHIKV isolates (April through October 2007) showed that all isolates posessed the E1-226A residue and were most closely related to Sri Lankan and Indian isolates from the same time period. Except for more frequent and persistent musculoskeletal symptoms, acute chikungunya infections mimicked DENV and other acute febrile illnesses. Only 12/797 (1.5%) patients had serological evidence of past chikungunya infection. Conclusions/SignificanceOur findings suggest CHIKV is a prominent cause of non-specific acute febrile illness in southern Sri Lanka.

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Section: Discussionsupporting

confidence: 59%

Chikungunya as a Cause of Acute Febrile Illness in Southern Sri Lanka

et al. 2013

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“…There have been only a few serological studies reported in this country on the presence of CHIKV-specific antibodies in patients and these antibodies were seen in 24·7%, 30·4% and 19·0% in suspected dengue patients between 1970–1972 [13], 1973–1974 [14] and in 1984 [15], respectively. In Sri Lanka, although the first outbreak was reported in 2006 [16], our results (samples collected in 2005–2006) indicated 6·1% positivity for CHIKV infection even before the recognition of the outbreak [16]. In this study, detection of anti-CHIKV IgM is a proof of recent CHIKV infection during the collection period and the detection of anti-CHIKV IgG further confirmed by neutralization test indicate the circulating situation of CHIKV in Myanmar, Sri Lanka, Indonesia, Philippines and Vietnam.…”

Section: Discussionmentioning

confidence: 99%

Retrospective seroepidemiological study of chikungunya infection in South Asia, Southeast Asia and the Pacific region

et al. 2016

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Chikungunya virus (CHIKV) and Ross River virus (RRV) of the genus Alphavirus, family Togaviridae are mainly transmitted by Aedes mosquitoes and the symptoms they cause in patients are similar to dengue. A chikungunya (CHIK) outbreak re-emerged in several Asian countries during 2005-2006. This study aimed to clarify the prevalence of CHIKV infection in suspected dengue patients in six countries in South Asia and Southeast Asia. Seven hundred forty-eight serum samples were from dengue-suspected patients in South Asia and Southeast Asia, and 52 were from patients in Fiji. The samples were analysed by CHIKV IgM capture ELISA, CHIKV IgG indirect ELISA and focus reduction neutralization test against CHIKV or RRV. CHIK-confirmed cases in South Asia, particularly Myanmar and Sri Lanka, were 4·6%, and 6·1%, respectively; and in Southeast Asia, particularly Indonesia, the Philippines and Vietnam, were 27·4%, 26·8% and 25·0%, respectively. It suggests that CHIK was widely spread in these five countries in Asia. In Fiji, no CHIK cases were confirmed; however, RRV-confirmed cases represented 53·6% of suspected dengue cases. It suggests that RRV is being maintained or occasionally entering from neighbouring countries and should be considered when determining a causative agent for dengue-like illness in Fiji.

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“…The limitation of the present study is that there was no anti-CHIK IgM or convalescent samples of IgG tested for confirming acute CHIK infection because we conducted this study one year after the outbreak. However, Panning et al [ 20 ] reported no evidence of CHIK antibodies before an outbreak in Sri Lanka, where the last severe CHIK epidemic occurred during the same period in Thailand in 1960s [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Association of ABO Blood Group Phenotype and Allele Frequency with Chikungunya Fever

Rujirojindakul

Chongsuvivatwong

Limprasert

2015

Advances in Hematology

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Background. The objective of this study was to investigate the association of the ABO blood group phenotype and allele frequency with CHIK fever. Methods. A rural community survey in Southern Thailand was conducted in August and September 2010. A total of 506 villagers were enrolled. Cases were defined as individuals having anti-CHIK IgG by hemagglutination ≥1 : 10. Results. There were 314 cases (62.1%) with CHIK seropositivity. Females were less likely to have positive anti-CHIK IgG with odds ratio (OR) (95% CI) of 0.63 (0.43, 0.93). All samples tested were Rh positive. Distribution of CHIK seropositivity versus seronegativity (P value) in A, B, AB, and O blood groups was 80 versus 46 (0.003), 80 versus 48 (0.005), 24 versus 20 (0.55), and 130 versus 78 (<0.001), respectively. However, chi-square test between ABO and CHIK infection showed no statistical significance (P = 0.76). Comparison of the ABO blood group allele frequency between CHIK seropositivity and seronegativity was not statistically significant. Conclusion. This finding demonstrated no association of the ABO blood group phenotypes and allele frequencies with CHIK infection.

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No evidence of chikungunya virus and antibodies shortly before the outbreak on Sri Lanka

Cited by 14 publications

References 19 publications

Chikungunya as a Cause of Acute Febrile Illness in Southern Sri Lanka

Chikungunya as a Cause of Acute Febrile Illness in Southern Sri Lanka

Retrospective seroepidemiological study of chikungunya infection in South Asia, Southeast Asia and the Pacific region

Association of ABO Blood Group Phenotype and Allele Frequency with Chikungunya Fever

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