No Evidence for Serotonergic-Adrenergic Interactions in the Canine Total Cardiovascular System

Abstract

Possible in vivo interactions of serotonin and noradrenaline were investigated in 7 anesthetized mongrel dogs. The hemodynamic effects of three different doses of serotonin (10, 50 and 100 μg/kg/min) were analyzed with and without noradrenaline treatment (0.05–0.1 μg/kg/min). There were no significant differences in peripheral and cardiac responses between the pure serotonin effect and the hemodynamic effects of a parallel serotonin-noradrenaline infusion. The discussed amplifying effect of serotonin on the adrenergic system could not be observed in the total canine cardiovascular system.