No evidence for lipid peroxidation in severe preeclampsia

Regan, Carmen; Levine, Richard J.; Baird, Donna D.; Ewell, Marian; Martz, Karen; Sibai, Bahaeddine M; Rokach, Joshua; Lawson, John A.; FitzGerald, Garret A.

doi:10.1067/mob.2001.116754

Cited by 81 publications

(48 citation statements)

References 24 publications

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“…4 Malondialdehyde, the most abundant reactive aldehyde derived of lipid peroxide breakdown, was one of the first biomarkers found elevated in preeclampsia. 3,28 However, in this study, representing a large sample of HDP, we did not observe any significant difference in malondialdehyde levels between hypertensive and normotensive pregnant women; published papers have shown different results in this respect as no significant difference has been described previously 29 but also other authors have found significant higher levels in preeclampsia compared with control group, with even higher levels when more severe disease. 7 As FFA levels, other important marker of lipid oxidation, were increased in all hypertensive groups compared with PCW, it is probable that the lack of differences in malondialdehyde among the groups could be explained by the small sample in which this determination was available.…”

Section: Discussioncontrasting

confidence: 70%

Abnormal levels of antioxidant defenses in a large sample of patients with hypertensive disorders of pregnancy

et al. 2011

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Increased levels of oxidative stress have been demonstrated in Preeclampsia in previous studies, but this finding has not been established in other hypertensive disorders in pregnancy (HDP). We measured different markers of lipid peroxidation and antioxidant defenses by spectrophotometry or enzymoimmunoanalysis in 339 pregnant women: 85 with gestational hypertension (GH), 88 chronic hypertension (CH), 104 Preeclampsia and 62 healthy pregnant control women (PCW). Lower activity of superoxide dismutase and higher levels of catalase were found in GH, CH and preeclampsia compared with PCW (964.4±116.5, 970.0±120.4, 971.2±137.5 and 1063.4±133.7 U g À1 Hb, Po0.001; and 313.0±71.7, 292.2±45.3, 297.1 ± 47.2, 215.5 ± 26.2 U mg À1 Hb, Po0.0001; respectively). Regarding the glutathione REDOX cycle, we found the following in GH, CH and preeclampsia compared with PCW: a decrease in its reduced form (2.6 ± 0.6, 2.7 ± 0.8, 2.7 ± 0.9, 3.3±1.3 lmol l À1 , Po0.003), a parallel increase in the oxidized form (185.6±68.9, 194.7±75.0, 184.3±78.3, 85.1±27.5 lmol l À1 , Po0.0001) and an increment in glutathione peroxidase (85.9±22.0, 86.4±20.9, 82.1±23.5 and 77.2 ± 19.7 U g À1 Hb, Po0.04) and glutathione reductase (6384.3 ± 1261.9, 6724.6 ± 1154.1, 6287.9 ± 1399.9 and 6044.4±1208.4 mU g À1 Hb, Po0.01, respectively). Nitrites/nitrates were higher in patients with preeclampsia than in PCW (31.50±15.08, 26.80±8.39 lmol l À1 , Po0.002). Although malondialdehyde and oxidized-LDL levels were similar among groups, free fatty acids were increased in every HDP (GH 514.6 ± 194.6, CH 501.3 ± 197.4, preeclampsia 555.2 ± 230.1 lmol l À1 ) compared with PCW (351.4 ± 146.1 lmol l À1 ), Po0.0001. Our results show an oxidation/reduction imbalance with an increase in oxidative stress coupled with a decreased capacity of antioxidant systems, not only in preeclampsia but also in every HDP.

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Section: Discussioncontrasting

confidence: 70%

Abnormal levels of antioxidant defenses in a large sample of patients with hypertensive disorders of pregnancy

et al. 2011

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“…High availability of unsaturated lipid could contribute to a predisposition to enhance lipid peroxidation. Several recent studies have reported that there is no evidence for increased lipid peroxidation in PIH (12).…”

Section: -200mentioning

confidence: 90%

Plasma antioxidant vitamins and lipid peroxidation products in pregnancy induced hypertension

Rao

Sumita

Roshni

et al. 2005

Indian J Clin Biochem

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It has been suggested that antioxidant systems are impaired in pregnancy induced hypertc, nsion and hence patients are exposed to oxidative stress. In order to investigate the relationship between lipid peroxidation and certain antioxidant parameters in blood of pregnancy induced hypertension (PIH) cases, 25 normotensive and 23 PIH samples were studied. In the present study, thiobarbitudc acid reactive substances showed a tendency to increase, however the increase remained statistically insignificant. Plasma ascorblc acid level remained unaltered and Vitamin E showed a tendency to increase in the study group. The findings implicate oxidative stress in the disease and cite the biochemical rationale for clinical trials of antioxidants to prevent and treat pregnancy induced hypertension.

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“…50 A few isolated studies, however, are not supportive of a role for oxidative stress in the maternal circulation. Two found no differences in markers of lipid peroxidation in either urine (the isoprostane 8,12-epi-iPF 2␣ -VI) 51 or plasma (8-epi-prostaglandin F 2␣ and MDA) 52 . Another, although describing similar serum MDA concentrations in women with preeclampsia to controls, has nonetheless reported a higher MDA/total antioxidant capacity ratio in women with preeclampsia, which, as the authors suggested, is indicative of oxidative stress.…”

Section: The Maternal Circulationmentioning

confidence: 96%

Oxidative Stress and Preeclampsia

2004

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Abstract-Preeclampsia remains a frequent and potentially dangerous complication of pregnancy. The cause remains largely unknown, but oxidative stress and a generalized inflammatory state are features of the maternal syndrome. The placenta appears to be the principal source of free radical synthesis but maternal leukocytes and the maternal endothelium are also likely contributors. Recent reports have suggested an important role for placental trophoblast NAD(P)H oxidase in free radical generation in preeclampsia. The antioxidant vitamin E is now known to have multiple actions in addition to prevention of lipid peroxidation (ie, inhibition of NAD(P)H oxidase activation and the inflammatory response). In view of the abnormally low plasma vitamin C concentrations in preeclampsia, a combination of vitamins C and E is a promising prophylactic strategy for prevention of preeclampsia. Key Words: preeclampsia Ⅲ oxidative stress Ⅲ antioxidants Ⅲ free radicals P reeclampsia affects between 0.4% and 2.8% of all pregnancies in developed countries and many more in developing countries, leading to as many as 8 370 000 cases worldwide per year. 1 This common disorder, which is more prevalent in first pregnancies, is associated with the highest maternal and fetal morbidity and mortality of all pregnancy complications, with Ͼ90% of the most serious outcomes occurring in developing countries. 1 According to the criteria of the International Society of the Study of Hypertension in Pregnancy, the preferred definition is a diagnosis of pregnancy-induced hypertension (diastolic blood pressure Ͼ90 mm Hg) occurring after week 20 of gestation with proteinuria (either Ն300 mg protein per day or an urinary protein/creatinine ratio Ն30 mg/mmol). 2 When patients have liver dysfunction, thrombocytopenia, and hemolysis, they are classified as having HELLP syndrome (ie, hemolysis, elevated liver enzymes, low platelets). 3 Although the definitions focus on these simply measured clinical parameters, preeclampsia must be recognized as a multisystem disorder, which variably may affect the brain, lungs, kidney, and liver.The risk of preeclampsia markedly increases in women with previous preeclampsia and in those with either preexisting vascular disease or conditions associated with increased cardiovascular risk, including renal disease, hypertension, diabetes, thrombophilia, and obesity (body mass index Ͼ29). 4 Additionally, occurrence in first-degree relatives increases the risk. Thus preeclampsia also has a hereditary origin, but inheritance does not follow simple Mendelian characteristics and a single "preeclampsia gene" is unlikely. Despite intensive effort, associations with polymorphisms of likely candidate genes, mostly associated with cardiovascular disease, have been weak, inconsistent, or negative. 5 Women who have had preeclampsia are also at greater risk for cardiovascular disease in later life, 6,7 and pregnancy, itself a transient state of the metabolic syndrome, is considered to represent a "stress test" that unmasks latent cardiovascu...

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No evidence for lipid peroxidation in severe preeclampsia

Cited by 81 publications

References 24 publications

Abnormal levels of antioxidant defenses in a large sample of patients with hypertensive disorders of pregnancy

Abnormal levels of antioxidant defenses in a large sample of patients with hypertensive disorders of pregnancy

Plasma antioxidant vitamins and lipid peroxidation products in pregnancy induced hypertension

Oxidative Stress and Preeclampsia

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