No Evidence for Increased Brain Tumour Incidence in the Swedish National Cancer Register Between Years 1980-2012

Nilsson, Jonas; Järås, Jacob; Henriksson, Roger; Holgersson, Georg; Bergström, Stefan; Estenberg, Jimmy; Augustsson, Torsten; Bergqvist, Michael

doi:10.21873/anticanres.13176

Cited by 14 publications

(13 citation statements)

References 12 publications

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“…Multiple studies have evaluated temporal trends in malignant brain tumor incidence, 5‐7 but few investigations have examined trends in benign brain tumors because reporting of these tumors to population‐based registries has not historically been required. Internationally, meningioma rates from the few longer standing population‐based registries to which these benign brain tumors have been reported have been generally stable in more recent years, 8‐11 whereas rising rates were reported earlier (eg, 1980s through early 2000s) in some areas of the United States, 12 from regional registries, 13,14 from multicenter neurosurgical facilities, 15 and among Nordic women 5 . Benign brain tumors have been reportable in the United States starting with cases diagnosed in 2004 (Public Law 107‐260; https://www.congress.gov/107/plaws/publ260/PLAW-107publ260.pdf; accessed April 16, 2020).…”

Section: Introductionmentioning

confidence: 99%

Nonmalignant meningioma and vestibular schwannoma incidence trends in the United States, 2004‐2017

Withrow

Devesa

Deapen

et al. 2021

Cancer

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Background Given concerns about risks associated with the growing use of mobile phones over recent decades, the authors analyzed temporal trends in incidence rates of nonmalignant meningioma and vestibular schwannoma in the United States. Methods The incidence of nonmalignant meningioma and vestibular schwannoma among adults in the Surveillance, Epidemiology, and End Results 18 registries during 2004 through 2017 was evaluated according to the method of diagnosis: microscopically (MC) or radiographically confirmed (RGC). Annual percent changes (APCs) and 95% CIs were estimated using log‐linear models. Results Overall meningioma rates (n = 108,043) increased significantly from 2004 to 2009 (APC, 5.4%; 95% CI, 4.4%‐6.4%) but subsequently rose at a slower pace through 2017 (APC, 1.0%; 95% CI, 0.6%‐1.5%). Rates for MC meningiomas changed little from 2004 to 2017 (APC, −0.3%; 95% CI, −0.7%, 0.1%) but rose rapidly for RGC meningiomas until 2009 (APC, 9.5%; 95% CI, 7.8%‐11.1%) and rose more modestly thereafter (APC, 2.3%; 95% CI, 1.5%‐3.0%). Overall vestibular schwannoma rates (n = 17,475) were stable (APC, 0.4%; 95% CI, −0.2%, 1.0%), but MC vestibular schwannoma rates decreased (APC, −1.9%; 95% CI, −2.7%, −1.1%), whereas RGC vestibular schwannoma rates rose (2006‐2017: APC, 1.7%; 95% CI, 0.5%‐3.0%). For each tumor, the trends by diagnostic method were similar for each sex and each racial/ethnic group, but RGC diagnosis was more likely in older patients and for smaller tumors. Meningioma trends and the proportion of RGC diagnoses varied notably by registry. Conclusions Overall trends obscured differences by diagnostic method in this first large, detailed assessment, but the recent stable rates argue against an association with mobile phone use. Variation among registries requires evaluation to improve the registration of these nonmalignant tumors. Lay Summary The etiology of most benign meningiomas and vestibular schwannomas is poorly understood, but concerns have been raised about whether mobile phone use contributes to risk of developing these tumors. Descriptive studies examining temporal trends could provide insight; however, globally, few registries collect these nonmalignant cases. In the United States, reporting benign meningiomas and vestibular schwannomas became required by law in 2004. This was the first large, systematic study to quantify and characterize incidence trends for meningioma and vestibular schwannoma according to whether the tumors were diagnosed microscopically or only radiographically. Differential trends across registries and by diagnostic method suggest that caution should be used when interpreting the patterns.

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Section: Introductionmentioning

confidence: 99%

Nonmalignant meningioma and vestibular schwannoma incidence trends in the United States, 2004‐2017

Withrow

Devesa

Deapen

et al. 2021

Cancer

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“…Within the framework of the countrywide, cooperative multicenter LGG studies/registries of the German GPOH, recruitment numbers for pediatric LGG doubled from 1997 to 2017, and incidence rates aligned with other European regions disposing of central registration pathways within the recent years [20,28,35,44]. LGG comprised only 30 % of all registered pediatric CNS tumors in Germany before 2000, while its fraction rose to almost 50 % nowadays.…”

Section: Discussionmentioning

confidence: 94%

“…We cannot assume complete registration for our adolescent age group, for which we lack adequate comparative data, as well. Adolescents were frequently included in wider age groups not allowing separate analysis [20,35,36,39]. The percentages of LGG of all pediatric CNS tumors and the incidence rates show a parallel pattern for the 0 to < 15 and 0 to < 18 years group in the time period 2009 to 2018, though with lower results when the adolescents are included.…”

Section: Temporal Trends In Lgg Patient Characteristics Following Rising Registrationmentioning

confidence: 99%

“…CNS tumor incidence trends have been reported from various European countries. No evidence for an increase was observed in Sweden between 1980 and 2012 with data analyzed for use of mobile phones, though the pediatric cases were integrated into a 0-39 year's age group [28,35]. Likewise, the incidence of low-grade glioma in the age group 0-14 years remained stable in the Netherlands between 1989 and 2003 [20] including LGG coded according to the International Classification of Diseases for Oncology (ICD-O) edition 1 to 3 [14] as well as clinically diagnosed tumors without histopathological confirmation.…”

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confidence: 97%

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Doubling Recruitment of Pediatric Low-grade Glioma within Two Decades does not change Outcome – Report from the German LGG Studies

et al. 2021

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Background Successive multicenter studies for pediatric low-grade glioma (LGG) in Germany were accompanied by a doubling of annual recruitment over 2 decades. We investigated whether this increase conveyed a change of epidemiologic characteristics or survival. Methods and results Participating centers reported 4634 patients with the radiologic/histologic diagnosis of LGG (1996–2018), rising from 109 to 278/year. Relating these numbers to all pediatric CNS tumors registered at the German Childhood Cancer Registry, the LGG fraction and annual crude incidence rates increased (32% to 51%; 0.94 to 2.12/100,000 children/adolescents<15 years). The consecutive LGG studies recruited 899 (HIT-LGG 1996), 1592 (SIOP-LGG 2004), and 1836 (LGG-registry) patients with similar distribution of tumor-sites, histology, and dissemination. 5-year overall survival was 96%-98% at median observation time of 8.1 years. Acknowledging unequal follow-up periods, 589/899 (66%), 1089/1582 (69%), and 1387/1836 (76%) patients remained under observation, while 1252/4317 received adjuvant treatment with decreasing frequency of front-line radiotherapy from 16% to 5%. Conclusion Pediatric LGG incidence rates in Germany are now comparable to other European countries. The rise in patient numbers followed implementation of standard-of-care treatment protocols, but did not result in relevant changes of epidemiologic or clinical parameters or survival. Shifts in patient distribution between treatment arms reflect growing acceptance of the LGG therapy algorithm.

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“…Although Karipidis et al (12) and Nilsson et al (13) found no evidence of an increased incidence of gliomas in recent years in Australia and Sweden, respectively, Karipidis et al (12) only reported on brain tumor data for ages 20–59 and Nilsson et al (13) failed to include data for high grade glioma. In contrast, others have reported evidence that increases in specific types of brain tumors seen in laboratory studies are occurring in Britain and the US:…”

Section: Carcinogenicitymentioning

confidence: 99%

Risks to Health and Well-Being From Radio-Frequency Radiation Emitted by Cell Phones and Other Wireless Devices

Miller

Sears

Morgan

et al. 2019

Front. Public Health

137

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Radiation exposure has long been a concern for the public, policy makers, and health researchers. Beginning with radar during World War II, human exposure to radio-frequency radiation 1 (RFR) technologies has grown substantially over time. In 2011, the International Agency for Research on Cancer (IARC) reviewed the published literature and categorized RFR as a “possible” (Group 2B) human carcinogen. A broad range of adverse human health effects associated with RFR have been reported since the IARC review. In addition, three large-scale carcinogenicity studies in rodents exposed to levels of RFR that mimic lifetime human exposures have shown significantly increased rates of Schwannomas and malignant gliomas, as well as chromosomal DNA damage. Of particular concern are the effects of RFR exposure on the developing brain in children. Compared with an adult male, a cell phone held against the head of a child exposes deeper brain structures to greater radiation doses per unit volume, and the young, thin skull's bone marrow absorbs a roughly 10-fold higher local dose. Experimental and observational studies also suggest that men who keep cell phones in their trouser pockets have significantly lower sperm counts and significantly impaired sperm motility and morphology, including mitochondrial DNA damage. Based on the accumulated evidence, we recommend that IARC re-evaluate its 2011 classification of the human carcinogenicity of RFR, and that WHO complete a systematic review of multiple other health effects such as sperm damage. In the interim, current knowledge provides justification for governments, public health authorities, and physicians/allied health professionals to warn the population that having a cell phone next to the body is harmful, and to support measures to reduce all exposures to RFR.

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No Evidence for Increased Brain Tumour Incidence in the Swedish National Cancer Register Between Years 1980-2012

Cited by 14 publications

References 12 publications

Nonmalignant meningioma and vestibular schwannoma incidence trends in the United States, 2004‐2017

Nonmalignant meningioma and vestibular schwannoma incidence trends in the United States, 2004‐2017

Doubling Recruitment of Pediatric Low-grade Glioma within Two Decades does not change Outcome – Report from the German LGG Studies

Risks to Health and Well-Being From Radio-Frequency Radiation Emitted by Cell Phones and Other Wireless Devices

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