No evidence for allelic association between bipolar disorder and monoamine oxidase a gene polymorphisms

Craddock, Nick; Daniels, J.; Roberts, E. E.; Rees, Mark I.; McGuffin, Peter

doi:10.1002/ajmg.1320600412

Cited by 60 publications

(53 citation statements)

References 5 publications

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“…Our ®ndings are consistent with previous published case-control association studies in patients of English [Furlong et al, 1999], and Japanese [Kunugi et al, 1999] origins, and a family-based analysis of British patient samples [Kirov et al, 1999], suggesting that our results are not falsenegative due to population strati®cation. A lack of association was also reported for other polymorphisms (a VNTR in intron 1, a (CA) n repeat in intron 2, an Fnu4HI-RFLP in exon 8, and an EcoRV polymorphism in exon 14) in the MAOA gene in patients with affective disorders [Craddock et al, 1995;No Èthen et al, 1995;Muramatsu et al, 1997;Parsian and Todd, 1997] and schizophrenia [Coron et al, 1996]. Taken together, the …”

Section: Resultsmentioning

confidence: 88%

Association analysis of the functional monoamine oxidase a gene promoter polymorphism in psychiatric disorders

et al. 2001

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Functional characterization studies revealed that transcriptional activity of the human monoamine oxidase A (MAOA) gene is modulated by a polymorphic repetitive sequence located approximately 1.2 kb upstream of the ATG codon. To investigate the possible influence of the allelic variants of the MAOA gene-linked polymorphic region (MAOA-LPR) on the genetic predisposition to psychiatric disorders, we have performed a case-control association study. 174 patients with affective disorders and 258 patients with schizophrenia according to DSM-IV, as well as 229 population controls were tested. Statistical analysis showed no significant differences in allele or genotype frequencies between control and patient groups. Our results suggest that there is no association between MAOA-LPR genotype and susceptibility to recurrent major depression, bipolar disorder, and schizophrenia in our population.

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Section: Resultsmentioning

confidence: 88%

Association analysis of the functional monoamine oxidase a gene promoter polymorphism in psychiatric disorders

et al. 2001

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“…Data were analyzed in two different ways for each marker as suggested by Craddock et al 37 First, we used a chi-square omnibus test to determine whether there was an overall association between pathological gambling and allele distribution at the marker locus. Data were tabulated as an a × 2 table where a is the number of alleles at the marker locus.…”

Section: Statistical Analysesmentioning

confidence: 99%

Pathological gambling and DNA polymorphic markers at MAO-A and MAO-B genes

et al. 2000

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This study was conducted to detect a possible association of MAOA and/or MAOB genes with pathological gambling (PG). DNA polymorphisms in MAOA and MAOB genes were screened by molecular analysis in 68 individuals (47 males and 21 females) meeting ICD-10 and DSM-IV criteria for pathological gambling and 68 healthy comparison controls matched for age and sex. There were no significant differences between pathological gamblers and healthy volunteers in overall allele distribution at the MAOA gene polymorphism. However there was a significant association between allele distribution and the subgroup of severe male gamblers (n = 31) compared to the males in the group of healthy volunteers ( 2 = 5246; df = 1; P Ͻ 0.05 [Bonferroni corrected]). No association was found between the MAOB polymorphic marker and PG. Allele variants at the MAOA, but not the MAOB gene may be a genetic liability factor in PG, at least in severe male gamblers. Molecular Psychiatry (2000) 5, 105-109.Pathological gambling is an impulse control disorder and it has also been proposed as a model of addiction without substance. 1 As defined by DSM-IV its essential feature is a persistent and recurrent maladaptive gambling behaviour. It is a progressive, chronic and highly disabling disorder that is poorly understood and often underdiagnosed despite affecting 1-3% of the adult population. 2 At present, little is known about the biological correlates of pathological gambling. A growing literature suggests the involvement of genetic factors in behavioral disorders related to pathological gambling such as alcoholism, substance abuse, attention-deficithyperactivity disorder, and smoking. 3 An increased incidence of about 20% of pathological gambling in first-degree relatives within clinical samples of pathological gamblers has been reported 4,5 and it has led to consideration of the possible role of a genetic component in the development of this disorder. Moreover, there is evidence for genetic influence derived from a large twin study performed on 3359 twin pairs in United States. This study revealed that inherited factors explained 62% of the diagnosis of pathological gambling disorder. 6 Recently, a positive association has been reported between pathological gambling and DNA polymorphism at the D2 and D4 receptor genes. 7,8 Monoamine oxidases A (MAOA) and B (MAOB) play a critical role in the degradation of several neurotransmitters which could be involved in the pathogenesis of pathological gambling. Decreased platelet MAOB activity has been reported in pathological gambling 9,10 and other impulse control disorders. 11,12 Although MAOA activity has never been studied in pathological gambling, previous research suggests that abnormal MAOA activity may play a role in the pathophysiology of disorders with impaired impulse control. 13 Decreased MAOA activity was associated with impulsive behaviors in several affected males from a large Dutch family with a mutation in that locus. 14 Differences in MAOA activity have been associated with specific alleles of th...

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“…In addition, the MAOA-LPR has been associated with bipolar disorders particularly in females (Ho et al, 2000), and with suicide in depressed males (Du et al, 2002), whereas other studies failed to detect association with suicidal behavior in mood disorders (Kunugi et al, 1999;Kirov et al, 1999;Syagailo et al, 2001;Ono et al, 2002). Although not consistently replicated (Craddock et al, 1995;Nothen et al, 1995), various other MAOA variations were found to influence addictive behavior (Parsian et al, 1995;Vanyukov et al, 1995;Hsu et al, 1996;Gade et al, 1998) and the risk for affective und anxiety disorders (Schulze et al, 2000;Deckert et al, 1999;Furlong et al, 1999). Finally, recent work focusing on both genetic and early environmental factors has begun to untangle expected complex relationships by demonstrating an interaction of MAOA-LPR genotype and adverse childhood environment modulating the risk for both conduct disorder and impulsive traits, antisocial behavior, aggressiveness, and violence in adulthood (Caspi et al, 2002;Foley et al, 2004;Huang et al, 2004).…”

Section: Introductionmentioning

confidence: 96%

Cluster B Personality Disorders are Associated with Allelic Variation of Monoamine Oxidase A Activity

Jacob

Müller

Schmidt

et al. 2005

Neuropsychopharmacol

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Genetic variants of the monoamine oxidase A (MAOA) have been associated with aggression-, anxiety-, and addiction-related behavior in several nonclinical and clinical populations. Here, we investigated the influence of allelic variation of MAOA activity on aggressionrelated personality traits and disease risk in patients with personality disorders. Personality disorders were diagnosed with the Structured Clinical Interview of DSM-IV and were allocated to cluster A, B, and C. Personality features were assessed by the revised NEO Personality Inventory and the Tridimensional Personality Questionnaire. The genotype of the MAOA gene-linked polymorphic region (MAOA-LPR) was determined in 566 patients with personality disorders and in 281 healthy controls. MAOA genotype was significantly associated with cluster B personality disorders (w 2 ¼ 7.77, p ¼ 0.005, df ¼ 1) but not with cluster C personality disorders. In total, 26.0% of cluster B patients were hemi-or homozygous for the low-activity variant of the MAOA genotype, compared to 16.4% in the control group. Associations between MAOA variants and personality domains related to impulsivity and aggressiveness were inconsistent. Our findings further support the notion that allelic variation of MAOA activity contributes modestly to the balance of hyper-(impulsiveaggressive) and hyporeactive (anxious-depressive) traits.

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No evidence for allelic association between bipolar disorder and monoamine oxidase a gene polymorphisms

Cited by 60 publications

References 5 publications

Association analysis of the functional monoamine oxidase a gene promoter polymorphism in psychiatric disorders

Association analysis of the functional monoamine oxidase a gene promoter polymorphism in psychiatric disorders

Pathological gambling and DNA polymorphic markers at MAO-A and MAO-B genes

Cluster B Personality Disorders are Associated with Allelic Variation of Monoamine Oxidase A Activity

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