Cholera is an acute, watery diarrheal disease. It can cause people to vomit and diarrhea, dehydration and even death, it is caused by vibrio cholerae. Cholera is very severe in south America and some underdeveloped poor countries, it can be translated by water, food, mosquito, and it can be transmitted through contact with infected people. A country with a low level of education is more vulnerable to cholera because the people don’t have an awareness that they must keep their food clean and take some defensive measures when contacting patients. The main means of preventing cholera is to improve water quality and hygiene, which, despite improvements in hygiene and clinical treatment of cholera, still causes about 100,000 deaths a year. In conclusion, even if humans have mastered many ways to control cholera, cholera will still cause a lot of death in a few underdeveloped countries.