No effects of ozonated autohemotherapy on inflammation response in hemodialyzed patients

Tylicki, Leszek; Biedunkiewicz, Bogdan; Rachoń, Dominik; Nieweglowski, Tomasz; Hak, Łukasz; Chamienia, Andrzej; Dębska‐Ślizień, Alicja; Aleksandrowicz, Ewa; Myśliwska, Jolanta; Rutkowski, Bolesław

doi:10.1080/09629350400014131

Cited by 9 publications

(10 citation statements)

References 18 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17,18 Ozone induces the repair of tissue damage through the release of several growth factors and by activating the body's own stem cells. 19,20 The occurrence of side effects during ozone therapy is still controversial: while some studies report the total absence of adverse effects, 6,21 other authors have reported side effects, especially for local, intradiscal and paravertebral injections: 22,23 there have been reports of burning sensations with subcutaneous injections at high concentrations and pain due to distension of the muscle fascia with paravertebral injections for herniated discs. This sensation can be reduced by injecting more slowly, at lower ozone concentrations and with reduced volumes of gaseous mixture.…”

Section: Introductionmentioning

confidence: 99%

The speed of reinfusion affects the vascular system during ozone major autohemotherapy

et al. 2017

View full text Add to dashboard Cite

Ozone major autohemotherapy (O-MAHT) is a way of ozonetherapy administration consisting of drawing patient's venous blood, mixing with oxygen/ozone, and reinfusing it into the vein. Some ozone therapists reported side effects during the O-MAHT, but the origin has not been described yet. We investigated the effect of blood drawing velocity during O-MAHT to see its effects on the vascular system and symptomatology. We administered O-MAHT to 11 subjects, and we interleaved fast and slow reinfusions. We monitored cerebral macrocirculation with transcranial Doppler (TCD) and tissue microcirculation with near-infrared spectroscopy (NIRS). Annoying symptoms appeared just during the fast reinfusion periods. NIRS and TCD parameters revealed vasoconstriction during fast reinfusion and improved metabolism during slow reinfusion. Overall, our investigation well discriminated fast from slow reinfusion velocity.

show abstract

Section: Introductionmentioning

confidence: 99%

The speed of reinfusion affects the vascular system during ozone major autohemotherapy

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Ozone maintains cellular antioxidant systems including glutathione, SOD and enzymatic reactions also preparing the host to confront the pathophysiologic conditions mediated by oxidative stress with repetitive doses. The dose and the method of administration are important for antioxidant efficiency of ozone [16]. Ozone is one of the most controversial gases because it is useful in the stratosphere to block UV radiation, but toxic in the troposphere during chronic air inhalation.…”

Section: Discussionmentioning

confidence: 99%

The ameliorative effect of ozone therapy on spinal cord ischemia in rabbits

Akman¹

2020

Ann Clin Anal Med

View full text Add to dashboard Cite

Aim: Research in applications of O3 treatment for spinal cord ischemia is a rich area of study. The effects of O3 treatment on spinal cord ischemia have not been studied much to date. The aim of this study is to investigate the role of prophylactic administration of O3 on the recovery of ischemic changes in terms of oxidative stress markers in lysosomal and mitochondrial enzymatic activities in the spinal cord of male rabbits. Material and Method: Twenty-four New Zealand White (NZW) adult male rabbits (weight: 2.5-3 kg) were obtained from Saki Yenilli Experimental Animals Center (Ankara, Turkey). The rabbits were housed in plastic cages at a temperature of 21 ± 2 °C, with 12 hours light/12 hours dark cyclus, fed with standard rabbit diet (Bil-Yem Ltd. Co., Ankara, Turkey) and water ad libitum for the duration of the experiment. Rabbits were randomly divided into 4 groups of 6 rabbits. The first group was accepted as control and the second group was treated with 50 μg/mL (20 mL) ozone by rectal insufflation 5 times per day. On the 10th day, animals were sacrificed. The third sham group had infrarenal abdominal aorta cross-clamping (IAACC) performed and were sacrificed 24 hours later. The fourth group was treated with 50 μg/mL ozone (20 mL) by rectal insufflation 5 times per day and on the 10th day, IAACC was performed. Twenty-four hours later the animals were sacrficed. Results: When data obtained from the biochemical analysis were investigated (Table 1) in the groups with induced ischemia, the expected reduction in SOD, CAT, and GPX enzyme activities was observed and an increase in MPO activity was observed. The statistical difference between ozone administered groups and the control group was significant (p < 0.05). When the ischemia+ozone group is compared with the ischemia group, the results are significant and a statistical difference is observed (p < 0.05). When GPX values in the group with ischemia-induced were investigated, the enzyme activity values were very low. A serious increase was observed in the ozone administered treatment group (p < 0.05). Discussion: Ozone (O3) is a molecule carrying three oxygen atoms forming as a result of exposure of oxygen to high energy electric currents and ultraviolet (UV) light in nature. It is found as a gas at room temperature. It is colorless, and has a characteristic smell. As ozone has a high degree of oxidation strength, it is called "active oxygen" in medicine. Due to its ability to increase blood circulation, it is used for treatment, not just of disorders related to circulation, but as an aid to the renewal of organic functions disrupted by many diseases.

show abstract

“…121 While elsewhere published data reported that ozone via O 2 -O 3 -MAHT triggered the release of microparticles from erythrocytes (102.0 ± 90.0 SD MPs/μl), from platelets (73.4 ± 52.5 SD MPs/μl), from leukocytes (34.3 ± 29.9 SD MPs/μl) and from endothelial cells (42.6 ± 31.1 SD MPs/μl), microparticles, isolated from fresh blood samples and identified by flow cytometry in healthy subjects, were almost higher in number. 120,121 Actually, microparticles originating from platelets [(237 x 10 6 /L, i.e., 237/μL (median; range 116-565)], erythrocytes (28 x 10 6 /L; 13-46), granulocytes (46 x 10 6 /L; 16-94) and endothelial cells (64 x 10 6 )/L; 16-136), were similar or even higher than microparticles elicited by ozone, so ascertaining that ozone and its oxidized metabolites do not exert any adverse effect on these systems. 120,121 Briefly speaking, previous reports have highlighted that, despite ozone may generate microparticles during its introduction into the circulating blood, the concentration of these particles is within the physiological level of particles usually produced during routine life.…”

Section: Effect Of Ozone Therapy On Coagulation and Fibrinolysismentioning

confidence: 99%

Ozone in the adjunct medical treatment. The round personality of a molecule with hormetic properties

Chirumbolo,

Tirelli,

Franzini

et al. 2023

Hum Exp Toxicol

View full text Add to dashboard Cite

Ozone, an allotrope of oxygen, is enjoying an increasing interest in the setting and management of the medical adjunct treatment, which is called, maybe too simplistically, “ozone therapy”. Ozone is not a medicine, so the word therapy does not properly fit this gaseous molecule. Like many natural compounds, for example plant flavonoids, even ozone interacts with aryl hydrocarbon receptors (AhRs) and, at low doses, it works according to the paradoxical mechanism of hormesis, involving mitochondria (mitohormesis). Ozone, in the hormetic range, exerts cell protective functions via the Nrf2-mediated activation of the anti-oxidant system, then leading to anti-inflammatory effects, also via the triggering of low doses of 4-HNE. Moreover, its interaction with plasma and lipids forms reactive oxygen species (ROS) and lipoperoxides (LPOs), generally called ozonides, which are enabled to rule the major molecular actions of ozone in the cell. Ozone behaves as a bioregulator, by activating a wide population of reactive intermediates, which usually target mitochondria and their turnover/biogenesis, often leading to a pleiotropic spectrum of actions and behaving as a tuner of the fundamental mechanisms of survival in the cell. In this sense, ozone can be considered a novelty in the medical sciences and in the clinical approach to pharmacology and medical therapy, due to its ability to target complex regulatory systems and not simple receptors.

show abstract

No effects of ozonated autohemotherapy on inflammation response in hemodialyzed patients

Cited by 9 publications

References 18 publications

The speed of reinfusion affects the vascular system during ozone major autohemotherapy

The speed of reinfusion affects the vascular system during ozone major autohemotherapy

The ameliorative effect of ozone therapy on spinal cord ischemia in rabbits

Ozone in the adjunct medical treatment. The round personality of a molecule with hormetic properties

Contact Info

Product

Resources

About