No effect of vitamin D supplementation on cardiovascular risk factors in subjects with metabolic syndrome: a pilot randomised study

Makariou, Stefania; Elisaf, Moses; Challa, Anna; Tentolouris, Nikolaοs; Liberopoulos, Evangelos

doi:10.5114/amsad.2017.70504

Cited by 20 publications

(48 citation statements)

References 65 publications

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“…Systolic blood pressure was not reduced by a mere 3.7% in the VitD group. In conclusion, VitD supplementation did not impact on CV disease risk factors in patients with metabolic syndrome [75].…”

Section: Antioxidant Therapy Vitamin D Supplementation and Blood Limentioning

confidence: 72%

Nonalcoholic Fatty Liver Disease: A Challenge from Mechanisms to Therapy

Tarantino

Citro

Capone

2019

JCM

114

109

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Focusing on previously published mechanisms of non-alcoholic fatty liver disease (NAFLD), their uncertainty does not always permit a clear elucidation of the grassroot alterations that are at the basis of the wide-spread illness, and thus curing it is still a challenge. There is somehow exceptional progress, but many controversies persist in NAFLD research and clinical investigation. It is likely that hidden mechanisms will be brought to light in the near future. Hereby, the authors present, with some criticism, classical mechanisms that stand at the basis of NAFLD, and consider contextually different emerging processes. Without ascertaining these complex interactions, investigators have a long way left ahead before finding an effective therapy for NAFLD beyond diet and exercise. few are conclusively accepted by experts. We try to provide evidence of the complexity, and for some aspects the contradictions, of the main lines of basic and clinical research addressing this topic. The Role of Reactive Oxygen Species (ROS) OverproductionMalnutrition splits in two directions; undernutrition and overnutrition; both of them leading to severe health complications: Famine and overweight/obesity are the result of calorie deficit or excess, and both of them are major health problems. Constantly eating excess calories leads body fat stores to expand. One of the most active and productive hypotheses about the mechanisms inducing or worsening obesity and consequently NAFLD is the over-production of reactive oxygen species (ROS). Oxidative stress accompanying obesity is reckoned to be a key factor in the development of insulin resistance (IR), [4]. In fact, obese mice treated with NADPH oxidase inhibitors (reducing ROS) have clearly demonstrated the involvement of ROS in the genesis of IR, hepatic steatosis, and T2DM [5]. Mitochondria are clearly considered to be main contributors to oxidative stress in obesity induced by chronic over-nutrition, with subsequent reduced insulin sensitivity or IR [6]. The trigger that causes the oxidative stress in obesity is the energy surplus that eventually generates reducing equivalents. These exceed the rate of ATP utilization, giving space to the over-production of O 2 , and consequently reducing the redox-buffering capacity [7]. The aforementioned pathway has been fully highlighted in mice, characterized by deletion of manganese superoxide dismutase at the adipocyte level through enhanced mitochondrial biogenesis, mediated by uncoupling protein 1 [8].

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Section: Antioxidant Therapy Vitamin D Supplementation and Blood Limentioning

confidence: 72%

Nonalcoholic Fatty Liver Disease: A Challenge from Mechanisms to Therapy

Tarantino

Citro

Capone

2019

JCM

114

109

View full text Add to dashboard Cite

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“…Observational studies assessing the association between vitamin D status in patients with MetS and predictive factors, as well as RCTs carried out with vitamin D supplementation, have shown controversial results. In both types of studies, there is no evidence that the lower levels of vitamin D observed in patients with MetS were a cause or a consequence of MetS, or if vitamin D supplementation had benefit across all components of MetS [ 12 , 14 , 16 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with metabolic syndrome: a protocol for systematic review and meta-analysis of randomized controlled trials

et al. 2020

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Background Vitamin D deficiency can play a role in extraskeletal functions that are involved with a set of risk factors associated with metabolic syndrome (MetS). The purpose of this review is to investigate the impact of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with MetS. Methods EMBASE, Medline, Web of Science, Lilacs, the Cochrane Central Register of Controlled Trials, clinicaltrials.gov databases, and grey literature will be systematically searched for randomized controlled trials (RCTs) of vitamin D supplementation compared with placebo, through December 2020. We will include in the study patients with MetS diagnosed by the criteria set forth by the National Cholesterol Education Program Adult Treatment Panel III or the International Diabetes Federation. The effect of oral vitamin D supplementation on lipid profile improvement (triglycerides, high-density lipoprotein cholesterol—HDL-C) is this review’s primary outcome. The systematic review will be performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The study screening, data extraction, and quality assessment will be fulfilled by two independent reviewers according to the Cochrane Risk of Bias tool (RoB 2.0). The results of the systematic review will be provided according to the type of intervention, characteristics of the target population, the methods of measurement of vitamin D, the calculated vitamin D concentrations, types of biological samples, and types of outcomes. Meta-analyses will be conducted where appropriate. The Cochran’s Q test and the I 2 -heterogeneity test will be used to assess the presence of heterogeneity and whether the fixed or the random-effects model would be appropriate for combining study results using the inverse variance method or the DerSimonian-Lair method, respectively. Publication bias will be evaluated using funnel plots and Egger’s and Begg’s tests. The strength of the evidence will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Discussion This systematic review will assess the effects of vitamin D supplementation on fasting glucose and triglyceride levels, waist circumference and mean blood pressure, and HDL-C among individuals with MetS. These findings may assist with decision-making within a clinical setting. Systematic review registration PROSPERO registration number CRD42019123212

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“…Observational studies have indicated an association between vitamin D deficiency and the onset and progression of T2D as well as future macrovascular events. 7,8 Moreover, in vivo and in vitro studies have proposed potential roles of vitamin D in glucose metabolism, e.g., stimulating insulin secretion via the vitamin D receptor on pancreatic β cells; modulating immune responses and lowering systematic inflammation; and reducing peripheral insulin resistance through vitamin D receptors in the muscles and liver. 11 However, evidence from interventional studies at a population level have been inconclusive.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D correction, therefore, may increase insulin secretion and improve glucose homeostasis; however, its effects on healthy individuals or in those with impaired glucose tolerance remain unclear. 6,7 In this study, we wish to determine the metabolic effects of oral vitamin D supplementation in a cohort of T2DM subjects. This study may reveal whether oral vitamin D supplementation can be an adjunct therapy in T2DM patients, and on the importance of optimizing vitamin D levels in the prevention and improved management of T2DM.…”

mentioning

confidence: 99%

Metabolic effects of oral vitamin D supplementation as an adjuvant therapy on subjects with type 2 diabetes

Tafseer¹,

Khan²,

Roy³

et al. 2019

Int J Basic Clin Pharmacol

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Background: It is common for patients with type 2 diabetes mellitus (T2DM) to have vitamin D deficiency. Aim of the study is to determine the metabolic effects of oral vitamin D supplementation in a cohort of T2DM subjects.Methods: Subjects with T2DM were divided into two groups. Group A (Control) included subjects who received the standard treatment (conventional antidiabetic drugs). Group B (Intervention), apart from the standard treatment (conventional antidiabetic drugs), was also supplemented with Vitamin D3. All the patients were followed up at baseline, 6 months, 12 months and 18 months.Results: Vitamin D deficiency was noted down in all the study subjects. Even after 18 months of supplementation, all subjects remained vitamin D deficient. There was a significant improvement in the circulating levels of 25-hydroxyvitamin D. Improvement in the lipid profile of subjects was observed as evidenced by a decrease in total cholesterol (5.0±0.92 mmol/l) as compared to baseline (5.5±1.6 mmol/l). HOMA-IR changed significantly after 18 months of supplementation from baseline (7.0±1.06 vs 10.8±1.96 nmol/l).Conclusions: Supplementation to achieve higher levels of vitamin D remains a promising adjuvant therapy for T2DM patients. Additionally, the intervention brought out a favourable change in HDL/LDL ratio among study subjects.

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No effect of vitamin D supplementation on cardiovascular risk factors in subjects with metabolic syndrome: a pilot randomised study

Cited by 20 publications

References 65 publications

Nonalcoholic Fatty Liver Disease: A Challenge from Mechanisms to Therapy

Nonalcoholic Fatty Liver Disease: A Challenge from Mechanisms to Therapy

Effects of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with metabolic syndrome: a protocol for systematic review and meta-analysis of randomized controlled trials

Metabolic effects of oral vitamin D supplementation as an adjuvant therapy on subjects with type 2 diabetes

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