No Effect of the Hemoglobin Solution HBOC-201 on the Response of the Rat R1H Tumor to Fractionated Irradiation

Raabe, Annette; Gottschalk, André; Hommel, Matthias; Dubben, Hans-Hermann; Strandl, Thomas

doi:10.1007/s00066-005-1418-3

Cited by 12 publications

(11 citation statements)

References 39 publications

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“…Details of this tumor system have been reported previously [13,17,22]. Cryoconserved stock tumors were serially passaged subcutaneously into the back (laterally, subcostally) of syngenic WAG/Rij albino rats.…”

Section: Tumor Host Systemmentioning

confidence: 99%

“…Cryoconserved stock tumors were serially passaged subcutaneously into the back (laterally, subcostally) of syngenic WAG/Rij albino rats. For details of the transplantation procedure and tumor maintenance see [13,17,18,22,24]. Animals were housed under conventional conditions and were provided with food and water ad libitum.…”

Section: Tumor Host Systemmentioning

confidence: 99%

“…Due to tumor growth between the days of entering, the maximal included volume amounted to about 2.5 cm 3 (range: 0.21-2.51 cm 3 ). Irradiation of unanesthetized animals was performed as described previously [17,18,22,24] using 200-kVp X-rays.…”

Section: Local Tumor Irradiation and Experimental Designmentioning

confidence: 99%

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Initially Accelerated Fractionation of the R1H Tumor of the Rat Increases Local Tumor Control and Might Reduce Impact of Overall Treatment Time

2007

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Section: Tumor Host Systemmentioning

confidence: 99%

Section: Tumor Host Systemmentioning

confidence: 99%

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Initially Accelerated Fractionation of the R1H Tumor of the Rat Increases Local Tumor Control and Might Reduce Impact of Overall Treatment Time

2007

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“…In addition, moderate tumor oxygenation potential was observed with high affinity HBOCs in a study conducted in 1998 [ 23 ]. A 2005 study demonstrated that low O 2 affinity PolyhHb oxygenated a rhabdomyosarcoma to a lesser extent than carbogen-based therapies [ 24 ]. In contrast, a 2008 computational simulation indicated that HBOCs with reduced O 2 affinities may selectively oxygenate hypoxic tissue [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: A theoretical and experimental study

Belcher

Baek

et al. 2018

PLoS ONE

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A major constraint in the treatment of cancer is inadequate oxygenation of the tumor mass, which can reduce chemotherapeutic efficacy. We hypothesize that polymerized human hemoglobin (PolyhHb) can be transfused into the systemic circulation to increase solid tumor oxygenation, and improve chemotherapeutic outcomes. By locking PolyhHb in the relaxed (R) quaternary state, oxygen (O2) offloading at low O2 tensions (<20 mm Hg) may be increased, while O2 offloading at high O2 tensions (>20 mm Hg) is facilitated with tense (T) state PolyhHb. Therefore, R-state PolyhHb may deliver significantly more O2 to hypoxic tissues. Biophysical parameters of T and R-state PolyhHb were used to populate a modified Krogh tissue cylinder model to assess O2 transport in a tumor. In general, we found that increasing the volume of transfused PolyhHb decreased the apparent viscosity of blood in the arteriole. In addition, we found that PolyhHb transfusion decreased the wall shear stress at large arteriole diameters (>20 μm), but increased wall shear stress for small arteriole diameters (<10 μm). Therefore, transfusion of PolyhHb may lead to elevated O2 delivery at low pO2. In addition, transfusion of R-state PolyhHb may be more effective than T-state PolyhHb for O2 delivery at similar transfusion volumes. Reduction in the apparent viscosity resulting from PolyhHb transfusion may result in significant changes in flow distributions throughout the tumor microcirculatory network. The difference in wall shear stress implies that PolyhHb may have a more significant effect in capillary beds through mechano-transduction. Periodic top-load transfusions of PolyhHb into mice bearing breast tumors confirmed the oxygenation potential of both PolyhHbs via reduced hypoxic volume, vascular density, tumor growth, and increased expression of hypoxia inducible genes. Tissue section analysis demonstrated primary PolyhHb clearance occurred in the liver and spleen indicating a minimal risk for renal damage.

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“…PbtO2 monitoring has also been used in animal models of spontaneous intracerebral hemorrhage [110,156], malignant soft tissue tumors [157,158], ischemic stroke [159], in experimental subarachnoid hemorrhage [160], in a swine model of pediatric traumatic brain injury [161], a rodent model of penetrating ballistic-like brain injury [162], in a rodent model of acclimation and deacclimation to hypoxia [163], in a standardized experimental brain death model [164], in experimental anhepatic liver failure [165,166], an in potassium-induced cortical spreading depression [167].…”

Section: Animalmentioning

confidence: 99%

Systematic and Comprehensive Literature Review of Publications on Direct Cerebral Oxygenation Monitoring

Lang

Jaeger²

2013

TOCCMJ

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This review has been compiled to assess publications related to the clinical application of direct cerebral tissue oxygenation (pbtO2) monitoring published in international, peer-reviewed scientific journals, or major meeting reports published as journal supplements. Its goal was to extract relevant, i.e. positive and negative, information on indications, clinical application, safety issues and impact on clinical situations, as well as treatment strategies in neurosurgery, neurosurgical anaesthesiology, neurosurgical intensive care, neurology, and related specialties. For completeness' sake it also presents related basic science research and case reports. This review is an update of its previous edition published elsewhere in 2007. This review reflects publications from 2004 to 2012. Only relevant publications prior to 2004, which explicitly addressed or systematically examined the above issues, are included in this review and are listed in the reference section. Based on 349 citations it is the most comprehensive review available on direct cerebral oxygen monitoring to this date.Keywords: Review, cerebral oxygenation, raumedic, licox, neurotrend, cerebral partial pressure of oxygen, brain tissue oxygenation. METHODSThis review is based on a systematic "Medline" literature search using the following search terms: licox, neurotrend, neurovent, raumedic, brain tissue oxygen, brain tissue oxygenation, cerebral oxygenation, cerebral tissue oxygen, cerebral partial pressure of oxygen, btO2, ptiO2, pti(O)2, ptiO(2), pbrO2, PBr(O2), P(bt)O(2), P(br)O(2), PbrO(2), BTpO2, tP(O2), PbO2, PbtO2, Pbto, PbtO(2).Only few publications were not retrieved using this technique. They were, however, identified through personal communication with scientists in the field, meeting proceedings and reviewer assignments. This strategy provided sufficient certainty that relevant papers have not been missed. Unpublished meeting abstracts and published conference proceedings were excluded for this review expect for few which provided comparative studies between different probes. To address relevant matters, related to specific pbtO2 issues, selected non-peer reviewed papers published in supplements were also used only when no other peer-reviewed information was available. RESULTSThis review is based on a previous review [1]. It is currently based on 349 papers, 274 more papers compared to its previous version in 2007, which warrants the update.

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No Effect of the Hemoglobin Solution HBOC-201 on the Response of the Rat R1H Tumor to Fractionated Irradiation

Abstract: Low-dose application of HBOC-201 does not improve the response of the rhabdomyosarcoma R1H of the rat to fractionated irradiation.

Cited by 12 publications

References 39 publications

Initially Accelerated Fractionation of the R1H Tumor of the Rat Increases Local Tumor Control and Might Reduce Impact of Overall Treatment Time

Initially Accelerated Fractionation of the R1H Tumor of the Rat Increases Local Tumor Control and Might Reduce Impact of Overall Treatment Time

The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: A theoretical and experimental study

Systematic and Comprehensive Literature Review of Publications on Direct Cerebral Oxygenation Monitoring

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