No Effect of Proton Pump Inhibitors on Crying and Irritability in Infants: Systematic Review of Randomized Controlled Trials

Gieruszczak‐Białek, Dorota; Konarska, Zofia; Skórka, Agata; Vandenplas, Yvan; Szajewska, Hania

doi:10.1016/j.jpeds.2014.11.030

Cited by 79 publications

(51 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The survey reported that 56% of general paediatricians prescribed proton pump inhibitors for infants with unexplained crying and, or, irritability and 38% prescribed them for infants with uncomplicated recurrent regurgitation and vomiting 30. According to a systematic review and meta‐analysis from 2015, there is no benefit in using any kind of proton pump inhibitors for crying and irritable infants 31.…”

Section: Pharmacological Management Of Fgids In Early Lifementioning

confidence: 99%

Review shows that parental reassurance and nutritional advice help to optimise the management of functional gastrointestinal disorders in infants

et al. 2018

Self Cite

View full text Add to dashboard Cite

AimRegurgitation, infantile colic and functional constipation are common functional gastrointestinal disorders (FGIDs) during infancy. Our aim was to carry out a concise review of the literature, evaluate the impact of these common FGIDs on infants and their families, and provide an overview of national and international guidelines and peer‐reviewed expert recommendations on their management.MethodsNational and international guidelines and peer‐reviewed expert recommendations on the management of regurgitation, infantile colic and functional constipation were examined and summarised.ResultsRegurgitation, infantile colic and functional constipation cause frequent parental concerns, lead to heavy personal and economic costs for families and impose a financial burden on public healthcare systems. Guidelines emphasise that the first‐line management of these common FGIDs should focus on parental education, reassurance and nutritional advice. Nutritional advice should stress the benefits of continuing breastfeeding, while special infant formulas may be considered for non‐breastfed infants with common FGIDs. Drug treatment is seldom required, with the exception of functional constipation.ConclusionBy providing complete and updated parental education, reassurance and nutritional advice, healthcare professionals can optimise the management of FGIDs and related symptoms and reduce the inappropriate use of medication or dietary interventions.

show abstract

Section: Pharmacological Management Of Fgids In Early Lifementioning

confidence: 99%

Review shows that parental reassurance and nutritional advice help to optimise the management of functional gastrointestinal disorders in infants

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…These reviews suggest that there is either no evidence of the effectiveness of pharmacological treatment or evidence of no effect, and there can be significant risks and negative side effects 1418 20 22–25…”

Section: Introductionmentioning

confidence: 99%

Costs associated with functional gastrointestinal disorders and related signs and symptoms in infants: a systematic review protocol

et al. 2016

Self Cite

View full text Add to dashboard Cite

IntroductionFunctional gastrointestinal disorders (FGIDs) and FGID-related signs and symptoms have a fundamental impact on the psychosocial, physical and mental well-being of infants and their parents alike. Recent reviews and studies have indicated that FGIDs and related signs and symptoms may also have a substantial impact on the budgets of third-party payers and/or parents. The objective of this systematic review is to investigate these costs.Methods and analysisThe population of interest is healthy term infants (under 12 months of age) with colic, regurgitation and/or functional constipation. Outcomes of interest will include the frequency and volume of reported treatments, the cost to third-party payers and/or parents for prescribed or over the counter treatments, visits to health professionals and changes in infant formula purchases, and the loss of income through time taken off work and out of pocket costs. Relevant studies will be identified by searching databases from 2005 onwards (including MEDLINE, EMBASE, PsycINFO, NEXIS, DARE, Health Technology Assessment database, National Health Service Economic Evaluation Database and others), conferences from the previous 3 years and scanning reference lists of eligible studies. Study selection, data extraction and quality assessment will be conducted by two independent reviewers and disagreements resolved in discussion with a third reviewer. Quality assessment will involve study design-specific checklists. Relevant studies will be summarised narratively and presented in tables. An overview of treatments and costs will be provided, with any geographical or other differences highlighted. An assessment of how the totals for cost differ across countries and elements that contribute to the differences will be generated.Ethics and disseminationThis is a systematic review of published studies that will be submitted for publication to a peer-reviewed journal. Ethical committee approval is not required.Trial registration numberCRD42016033119.

show abstract

“…Clinical exam of infants was performed by the author and maxillary lip and ankyloglossia was confirmed using the Hazelbaker assessment tool for lingual frenulum function with a score of < 8 indicating surgical intervention [7]. Kotlow classification system for maxillary labial frenulum was utilized to characterize anatomic position [8][9][10].…”

Section: Methodsmentioning

confidence: 99%

Aerophagia Induced Reflux in Breastfeeding Infants With Ankyloglossia and Shortened Maxillary Labial Frenula (Tongue and Lip Tie)

Siegel

2016

Int J Clin Pediatr

View full text Add to dashboard Cite

show abstract

No Effect of Proton Pump Inhibitors on Crying and Irritability in Infants: Systematic Review of Randomized Controlled Trials

Cited by 79 publications

References 24 publications

Review shows that parental reassurance and nutritional advice help to optimise the management of functional gastrointestinal disorders in infants

Review shows that parental reassurance and nutritional advice help to optimise the management of functional gastrointestinal disorders in infants

Costs associated with functional gastrointestinal disorders and related signs and symptoms in infants: a systematic review protocol

Aerophagia Induced Reflux in Breastfeeding Infants With Ankyloglossia and Shortened Maxillary Labial Frenula (Tongue and Lip Tie)

Contact Info

Product

Resources

About