No effect of added β-glucan or of fructooligosaccharide on appetite or energy intake

Abstract

Consumption of beta-glucan, FOS, or a combination thereof in meal-replacement bars at the levels tested for 2 consecutive days does not improve appetite control. Efficacy may have improved if the consumption period was longer, if the content of beta-glucan was greater, or if a form of beta-glucan that generates even higher gastric viscosity was consumed. This trial was registered at (clinicaltrials.gov) as NCT00776256.

The modulatory role of high fat feeding on gastrointestinal signals in obesity

“…For example, gut microbiota can alter chemosensory machinery responsible for nutrient sensing and response [44,245], and controlled changes in microbiota composition and profile can result in increased satiety and decreased food intake. Although studies in rodent demonstrate a clear beneficial effect in ameliorating metabolic dysregulations through manipulation of gut microbiota composition via antibiotics, prebiotics or probiotics [265], studies in humans are less convincing [266][267][268][269][270]. Nevertheless, gut signaling pathways represented by nutrient receptors, peptides and microbiota have risen to the forefront in our quest for developing successful strategies in curbing the incidence of obesity.…”

Satiating Effect of a Barley Beta-Glucan–Enriched Snack

“…The incongruence was especially depending on the source and amount of b-glucan consumed by subjects as well as the time interval between the b-glucan consumption and the ad libitum lunch (when measures of energy intake were evaluated) [39][40][41][42][43].…”

Dose-response impact of a soluble fiber, NUTRIOSE®, on energy intake, body weight and body fat in humans

“…Fiber includes a wide range of compounds; not all are equally effective at affecting satiety [10,[20][21][22][23][24]. Viscous fiber, such as guar gum, oat bran, and psyllium, are generally more effective, although insoluble fibers that survive gut transit, such as wheat bran and cellulose, are also known to alter satiety [10].…”