No detrimental effect from chronic exposure to buprenorphine on corticosteroid-binding globulin and corticosensitive immune parameters

D’Elia, Michele; Patenaude, Johane; Hamelin, Claudine; Garrel, Dominique R.; Bernier, Jacques

doi:10.1016/s1521-6616(03)00177-3

Cited by 35 publications

(24 citation statements)

References 30 publications

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“…Indeed, it has a more slow-going activity observable essentially at 5 days after a burn injury. Incidentally, total Cort levels observed for burned mice 5 days postburn would have been lower if it was not for the stimulatory effect of the drug on the HPA axis at that time (10). The absence of a rise in free Cort levels suggests an increase of binding to plasma proteins.…”

Section: Discussionmentioning

confidence: 97%

Corticosterone binding globulin regulation and thymus changes after thermal injury in mice

D’Elia¹,

Patenaude²,

Hamelin³

et al. 2005

American Journal of Physiology-Endocrinology and Metabolism

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Section: Discussionmentioning

confidence: 97%

Corticosterone binding globulin regulation and thymus changes after thermal injury in mice

D’Elia¹,

Patenaude²,

Hamelin³

et al. 2005

American Journal of Physiology-Endocrinology and Metabolism

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“…It appears that its respiratory effects are limited, unlike morphine and fentanyl which have been shown to have no ceiling effect for analgesia but which can cause severe respiratory depression and apnea in high doses. No detrimental effect from chronic exposure to buprenorphine has been shown on corticosensitive immune parameters (D’Elia et al 2003). Gomez-Flores and Weber (2000) showed that buprenorphine, unlike morphine, was not associated with immunosuppression and did not activate the hypothalamic–pituatary axis.…”

Section: Comparison Of Side Effects With Other Opioidsmentioning

confidence: 99%

Management of chronic pain in the elderly: focus on transdermal buprenorphine

Vadivelu¹,

Hines²

2008

CIA

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Chronic pain in the elderly is a signifi cant problem. Pharmacokinetic and metabolic changes associated with increased age makes the elderly vulnerable to side effects and overdosing associated with analgesic agents. Therefore the management of chronic cancer pain and chronic nonmalignant pain in this growing population is an ongoing challenge. New routes of administration have opened up new treatment options to meet this challenge. The transdermal buprenorphine matrix allows for slow release of buprenorphine and damage does not produce dose dumping. In addition the long-acting analgesic property and relative safety profi le makes it a suitable choice for the treatment of chronic pain in the elderly. Its safe use in the presence of renal failure makes it an attractive choice for older individuals. Recent scientifi c studies have shown no evidence of a ceiling dose of analgesia in man but only a ceiling effect for respiratory depression, increasing its safety profi le. It appears that transdermal buprenorphine can be used in clinical practice safely and effi caciously for treating chronic pain in the elderly.

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“…Methadone, for instance, has been variously reported to improve (12), impair (11,13), or have no effect (14) on immune function. Similarly, buprenorphine has been variously reported to improve (15)(16)(17) or to suppress (7,8,13) immune function, or to have no effect at all (10,18). Such conflicting information makes it difficult to establish best practices for medical intervention of opioid abuse.…”

mentioning

confidence: 99%

Morphine Produces Immunosuppressive Effects in Nonhuman Primates at the Proteomic and Cellular Levels

Brown

Ortiz

Angel

et al. 2012

Molecular & Cellular Proteomics

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Morphine has long been known to have immunosuppressive properties in vivo, but the molecular and immunologic changes induced by it are incompletely understood. To explore how these changes interact with lentiviral infections in vivo, animals from two nonhuman primate species (African green monkeys and pigtailed macaques) were provided morphine and studied using a systems biology approach. Biological specimens were obtained from multiple sources (e.g. lymph node, colon, cerebrospinal fluid, and peripheral blood) before and after the administration of morphine (titrated up to a maximum dose of 5 mg/kg over a period of 20 days). Cellular immune, plasma cytokine, and proteome changes were measured and morphine-induced changes in these parameters were assessed on an interorgan, interindividual, and interspecies basis. In both species, morphine was associated with decreased levels of Ki-67 ؉ T-cell activation but with only minimal changes in overall T-cell counts, neutrophil counts, and NK cell counts. Although changes in T-cell maturation were observed, these varied across the various tissue/ fluid compartments studied. Proteomic analysis revealed a morphine-induced suppressive effect in lymph nodes, with decreased abundance of protein mediators involved in the functional categories of energy metabolism, signaling, and maintenance of cell structure. These findings have direct relevance for understanding the impact of heroin addiction and the opioids used to treat addiction as well as on the potential interplay between opioid abuse and the immunological response to an infective agent. Molecular & Cellular

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No detrimental effect from chronic exposure to buprenorphine on corticosteroid-binding globulin and corticosensitive immune parameters

Cited by 35 publications

References 30 publications

Corticosterone binding globulin regulation and thymus changes after thermal injury in mice

Corticosterone binding globulin regulation and thymus changes after thermal injury in mice

Management of chronic pain in the elderly: focus on transdermal buprenorphine

Morphine Produces Immunosuppressive Effects in Nonhuman Primates at the Proteomic and Cellular Levels

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