No Detection of Interferon‐γ Activity During Early Pregnancy in the Mouse

Bonnardière, Claude La

doi:10.1111/j.1600-0897.1993.tb00597.x

Cited by 14 publications

(3 citation statements)

References 20 publications

(10 reference statements)

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“…In mice, knock-out experiments showed that IFN-γ is not required for normal embryonic development or the generation of a specific immune response [38]. These findings confirmed previous results showing that no IFN (type I or type II) can be detected during early pregnancy in mice [44].…”

Section: Possible Role In Conceptus Implantationsupporting

confidence: 81%

“…Other evidence that IFN-γ is secreted by the human villous syncytiotrophoblast and extravillous trophoblast in decidua during the first trimester of pregnancy was found, followed by a significant decline in secretion up to term pregnancy, where only a weak signal of IFN-γ was detected in extravillous trophoblast in the decidua [63]. In mice, no IFNs or IFN-like activity was detected during early pregnancy [44].…”

Section: Embryonic Interferons In Mammalsmentioning

confidence: 98%

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Trophoblastic interferon-gamma: current knowledge and possible role(s) in early pig pregnancy

Cencič

Bonnardière

2002

Vet. Res.

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-In the pig as in ruminant species, the implantation of the elongated conceptus -the embryo with its associated membranes -onto the maternal uterus is accompanied by an intense secretion of interferon (IFN), which culminates at day 15 of development. It has been shown that in fact the pig trophectoderm -the polarized epithelium which lines the conceptus -simultaneously secretes two types of interferons: IFN-gamma (IFN-γ ), which is the more abundant species, is produced in very substantial amounts. Another IFN is also secreted, which happens to be a novel type I IFN, now named IFN-δ. It was previously shown that the uterus is the most probable target of the pig trophoblastic IFNs, since no autocrine effect was found on the trophoblast. It has also been shown that, unlike for the ruminant species, the pig trophoblastic IFNs do not play an apparent role in the so-called maternal recognition of pregnancy. We have focused this review on IFN-γ , because first, it is the major species secreted and secondly, IFN-γ has various regulatory effects on different tissues, including lymphoid cells. We particularly address the question of the possible role of trophoblastic IFN-γ in early pregnancy, in the light of the known biological functions of human and mouse IFN-γ .interferon-gamma / embryo / trophoblast / pig / implantation Résumé -Interféron-gamma trophoblastique : état actuel des connaissances et rôle(s) possible(s) en début de gestation chez le porc. Chez le porc, comme chez les ruminants, l'implantation du conceptus (l'embryon et ses membranes annexes) dans l'utérus maternel s'accompagne d'une intense sécrétion d'interféron (IFN), laquelle culmine au 15 e jour du développement. On a montré que le trophectoderme -l'épithélium polarisé qui borde le conceptus -sécrète simultanément deux types d'IFN : l'IFN-gamma, qui est le plus abondant, est produit en très grande quantité. L'autre interféron, apparenté aux IFN de type I, s'avère être une nouvelle espèce, nommée IFN-δ. Des résultats antérieurs ont montré que l'utérus est la cible la plus probable des interférons trophoblastiques, puisqu'aucun effet autocrine 139 Vet. Res. 33 (2002) 139-157

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Section: Possible Role In Conceptus Implantationsupporting

confidence: 81%

Section: Embryonic Interferons In Mammalsmentioning

confidence: 98%

Trophoblastic interferon-gamma: current knowledge and possible role(s) in early pig pregnancy

Cencič

Bonnardière

2002

Vet. Res.

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“…It is induced in the early decidua and remains cytoplasmic in the trophectodermal lineages throughout placental development [17]. By midpregnancy, IFNG is detected in trophoblast giant cells [18,19]. IFNG receptor 1 (IFNGR1) and IFNGR2 are found on mouse oocytes and preimplantation embryos.…”

Section: Introductionmentioning

confidence: 99%

Interferon Gamma in Successful Pregnancies1

Murphy

Tayade

Ashkar

et al. 2009

Biology of Reproduction

247

191

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Interferon gamma (IFNG) is a proinflammatory cytokine secreted in the uterus during early pregnancy. It is abundantly produced by uterine natural killer cells in maternal endometrium but also by trophoblasts in some species. In normal pregnancies of mice, IFNG plays critical roles that include initiation of endometrial vasculature remodeling, angiogenesis at implantation sites, and maintenance of the decidual (maternal) component of the placenta. In livestock and in humans, deviations in these processes are thought to contribute to serious gestational complications, such as fetal loss or preeclampsia. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression. Lack of MHC class II antigens on trophoblasts is thought to facilitate survival of the semiallogeneic conceptus in the presence of maternal lymphocytes. This review describes the dynamic roles of IFNG in successful pregnancy and briefly summarizes data on IFNG in gestational pathologies.

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Cytokines in mammalian reproduction and speculation about their possible involvement in nonmammalian viviparity

Paulesu

1997

Microsc. Res. Tech.

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No Detection of Interferon‐γ Activity During Early Pregnancy in the Mouse

Abstract: We conclude that in this rodent species IFN-gamma is most probably not involved in early maternal-fetal interactions.

Cited by 14 publications

References 20 publications

Trophoblastic interferon-gamma: current knowledge and possible role(s) in early pig pregnancy

Trophoblastic interferon-gamma: current knowledge and possible role(s) in early pig pregnancy

Interferon Gamma in Successful Pregnancies1

Cytokines in mammalian reproduction and speculation about their possible involvement in nonmammalian viviparity

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