No demonstrable association between the Leningrad-Zagreb mumps vaccine strain and aseptic meningitis in a large clinical trial in Egypt

Sharma, Hitt; Oun, Saeed Aly; Bakr, Shermine S. Abou; Kapre, Subhash V.; Jadhav, Suresh; Bhardwaj, Subodh

doi:10.1111/j.1469-0691.2009.03121.x

Cited by 3 publications

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“…Injection site reactions were estimated to be 4.58/ 1000 immunisation (0.46%) in our study which is considerably lower than the rates reported from India (4.3%) and Egypt (5.25%) with the same MMR vaccine preparation [21,25]. Even the WHO has reported a much higher rate of 17-30% [12].…”

Section: Discussioncontrasting

confidence: 53%

“…This could be explained by differences in injection techniques, skill of the vaccinators, age of study participants, reporting methods and definitions used for detecting injection site reactions. In addition, we have used stringent case definitions for injection site reactions while most other studies have not reported the case definitions which they used [21,25].…”

Section: Discussionmentioning

confidence: 99%

“…Despite some safety concerns reported from Brazil, the preparation is believed to be safe, as subsequent studies have reported that the rate of serious adverse events following this extensively used preparation is low [22][23][24][25][26][27]. This observation was supported by the World Health Organization and individual authors [11,28,29].…”

Section: Introductionmentioning

confidence: 96%

“…Paper However, the above are not without methodological limitations inherent to safety monitoring such as under reporting, different surveillance methods and retrospective study design resulting in difficulty in carrying out valid comparison [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

“…A large (N = 453,119) clinical trial from Egypt reported that incidence of fever (2.51%), injection site pain (2.37%), rash (0.17%) and parotitis (0.04%) following the same MMR vaccine preparation which is currently used in Sri Lanka, when given at the age of 18-24 months [25].…”

Section: Introductionmentioning

confidence: 99%

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Active safety monitoring of measles-mumps-rubella vaccine in the National Immunisation Programme of Sri Lanka

et al. 2017

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Objectives This study was designed to report incidence and characteristics of selected adverse events following immunisation which have consistent causal association (AEFIc) with Measles-Mumps-Rubella (MMR) vaccination given at the age of one year in the National Immunisation Programme of Sri Lanka.Methods The data presented here were obtained from a cohort event monitoring study. It was carried out in the Jaffna Regional Directorate of Health Services area from November 2012 to December 2014. A representative sample of 3002 infants who received MMR immunisation were actively followed up for adverse events (AE) using over the phone interviews, self-reporting, and home or hospital visits up to 45 days. All AEs were reviewed by two investigators independently in two step-wise processes to detect the AEFIc. Seven AEFIc were detected using standard case definitions and onset time limit criteria. They were subjected to further analysis to describe the incidence rates and characteristics.Results Of the 2398 (80%) infants who completed follow up of 45 days, 1321 infants experienced 2621 AEFI. Of them 209 were classified as AEFIc. Incidence of AEFIc was 87/ 1000 immunisation. They were mainly nonserious and resolved completely. There were no fatal or life threatening AEFIs. Incidence per 1000 immunisations; allergic reactions 0.83, injection site reactions 4.58, fever100.4° F or lasting more than  3 days 9.59, macular papular rash 2.92, parotitis 2.92 and generalised convulsions 1.25. ConclusionThe MMR vaccine used in NIP of Sri Lanka had low incidence of AEFIc and were mainly non-serious in nature.

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Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Active safety monitoring of measles-mumps-rubella vaccine in the National Immunisation Programme of Sri Lanka

et al. 2017

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Live attenuated vaccines: Historical successes and current challenges

2015

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Live attenuated vaccines against human viral diseases have been amongst the most successful cost effective interventions in medical history. Smallpox was declared eradicated in 1980; poliomyelitis is nearing global eradication and measles has been controlled in most parts of the world. Vaccines function well for acute diseases such as these but chronic infections such as HIV are more challenging for reasons of both likely safety and probable efficacy. The derivation of the vaccines used has in general not been purely rational except in the sense that it has involved careful clinical trials of candidates and subsequent careful follow up in clinical use; the identification of the candidates is reviewed.

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Insight and Control of Infectious Disease in Global Scenario

Roy¹

2012

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No demonstrable association between the Leningrad-Zagreb mumps vaccine strain and aseptic meningitis in a large clinical trial in Egypt

Cited by 3 publications

References 0 publications

Active safety monitoring of measles-mumps-rubella vaccine in the National Immunisation Programme of Sri Lanka

Active safety monitoring of measles-mumps-rubella vaccine in the National Immunisation Programme of Sri Lanka

Live attenuated vaccines: Historical successes and current challenges

Insight and Control of Infectious Disease in Global Scenario

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