No Decrease in Clindamycin Susceptibility Despite Increased Use of Clindamycin for Pediatric Community-Associated Methicillin-Resistant Staphylococcus Aureus Skin Infections

Szczesiul, Jillian M.; Shermock, Kenneth M.; Murtaza, Umbreen; Siberry, George K.

doi:10.1097/inf.0b013e318124aa5c

Cited by 30 publications

(18 citation statements)

References 9 publications

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“…First, the community prevalence of MRSA colonization in children is increasing nationwide and in Baltimore ( 30 – 32 ), largely the result of spread of CA-MRSA strains. Second, children generally have less exposure to healthcare settings where they would be exposed to traditional HA-MRSA strains.…”

Section: Discussionmentioning

confidence: 99%

Community-associated Methicillin-ResistantStaphylococcus aureusStrains in Pediatric Intensive Care Unit1

Milstone¹,

Carroll²,

Ross³

et al. 2010

Emerg. Infect. Dis.

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Section: Discussionmentioning

confidence: 99%

Community-associated Methicillin-ResistantStaphylococcus aureusStrains in Pediatric Intensive Care Unit1

Milstone¹,

Carroll²,

Ross³

et al. 2010

Emerg. Infect. Dis.

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“…Clindamycin remains a mainstay of therapy for uncomplicated CA-MRSA SSTIs in much of the United States, although some researchers have suggested that resistance may be increasing among CA-MRSA strains (235,361 (874). A group from Baylor University in 2000 to 2002 found in an uncontrolled study that clindamycin was effective for invasive community-onset MRSA infections of children (585).…”

Section: Treatment Of Ca-mrsa Infections Uncomplicated Sstismentioning

confidence: 99%

Community-Associated Methicillin-ResistantStaphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic

2010

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SUMMARY Staphylococcus aureus is an important cause of skin and soft-tissue infections (SSTIs), endovascular infections, pneumonia, septic arthritis, endocarditis, osteomyelitis, foreign-body infections, and sepsis. Methicillin-resistant S. aureus (MRSA) isolates were once confined largely to hospitals, other health care environments, and patients frequenting these facilities. Since the mid-1990s, however, there has been an explosion in the number of MRSA infections reported in populations lacking risk factors for exposure to the health care system. This increase in the incidence of MRSA infection has been associated with the recognition of new MRSA clones known as community-associated MRSA (CA-MRSA). CA-MRSA strains differ from the older, health care-associated MRSA strains; they infect a different group of patients, they cause different clinical syndromes, they differ in antimicrobial susceptibility patterns, they spread rapidly among healthy people in the community, and they frequently cause infections in health care environments as well. This review details what is known about the epidemiology of CA-MRSA strains and the clinical spectrum of infectious syndromes associated with them that ranges from a commensal state to severe, overwhelming infection. It also addresses the therapy of these infections and strategies for their prevention.

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“…9,10,16,[20][21][22][23][24] we observed exacerbation of lesion in summer. We report contact with soil, cow dung, intake of animal protein, excess of alcohol, excessive sweating as the precipitating factors, in line with earlier reports.…”

Section: Therapeutic Outcomementioning

confidence: 90%

Clinico-etiological profile and antibiotic sensitivity pattern of chronic folliculitis: a common but less focussed disease of tropics

Pasha

Gunda

2018

Int J Res Dermatol

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Background: Chronic folliculitis (CF), a common disease of the tropics caused by Staphylococcus aureus (SA) is a less focussed therapeutic area.Methods: We estimated the prevalence of CF, clinical types, seasonal variation through this prospective observational study and carried out routine laboratory investigations, gram stain, KOH mounting, Tzanck smear, and culture and sensitivity (C&S).Results: Of 50 patients (prevalence 1.2%), 44 were men. Mean age was 36.5 years (range 18-55 years). Patients were from lower socioeconomic class (7%), comprised of unskilled (82%) workers, and presented with pustules (6%) and pruritis (18%). Dermatitis cruris pustulosa et atrophicans (78%) and folliculitis barbaetraumatics (6%), lesions on the lower limbs (74%), and beard area in men (18%), human immunodeficiency virus infection (8%) and diabetes mellitus (4%) were common observations. Shorter duration (6-8 months) was reported in more number of women (4/6,) while men (35/44) had a long-standing disease (8 months-2 years). Six had a duration of >2 years. Summer aggravated the symptoms (90%). Contact with soil, cow dung, intake of animal protein, excess alcohol, excessive sweating were the precipitating factors. Culture positive coagulase negative SA (98.0%) was the most common isolate. Organisms were sensitive to ceftriaxone (9%), cepholathin (7%) and resistant to penicillins (68%); there was no resistance against gatifloxacin, imipenam, vancomycin, and teicoplanin. Twenty seven patients had a complete cure.Conclusions: CF is a recurrent condition with seasonal variation, predominantly involves legs, and affects adult labourers. Avoiding aggravating factors (trauma) is helpful in achieving the treatment goal and minimising recurrence. Prescription of Antibiotics should be considered after testing for C&S.

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No Decrease in Clindamycin Susceptibility Despite Increased Use of Clindamycin for Pediatric Community-Associated Methicillin-Resistant Staphylococcus Aureus Skin Infections

Cited by 30 publications

References 9 publications

Community-associated Methicillin-ResistantStaphylococcus aureusStrains in Pediatric Intensive Care Unit1

Community-associated Methicillin-ResistantStaphylococcus aureusStrains in Pediatric Intensive Care Unit1

Community-Associated Methicillin-ResistantStaphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic

Clinico-etiological profile and antibiotic sensitivity pattern of chronic folliculitis: a common but less focussed disease of tropics

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