No Correlation between Anti-drug Antibodies and Therapeutic Response
in Tunisian Patients with Chronic Inflammatory Diseases Treated by TNF
Blockers
Selma Bouden,
Lilia Laadhar,
Jihene Soua
et al.
Abstract:Introduction:
Tumor necrosis factor alpha (TNF alpha) blockers such as infliximab
(IFX) and adalimumab (ADA) had significantly changed the course of inflammatory diseases
such as rheumatoid arthritis (RA), spondyloarthritis (SpA) and Crohn's disease (CD). However,
about 30% of patients do not respond to these treatments. This lack of response may be due to the
formation of antibodies against these drugs (anti-drug antibodies: ADAbs). The aim of this study
was to determine the prevalence of ADAbs against IFX an… Show more
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