No cognitive deficits in men formerly exposed to lead

Winker, Robert; Barth, Alfred; Ponocny‐Seliger, Elisabeth; Pilger, Alexander; Osterode, W.; Rüdiger, H. W.

doi:10.1007/s00508-005-0466-0

Cited by 15 publications

(14 citation statements)

References 21 publications

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“…Osterberg et al (35) reported no sign of behavioural deterioration in lead-exposed individuals, either in objective cognitive tests or in subjective symptom/ mood self-rating scales. Similarly, Winker et al (36) found no signifi cant differences in cognitive parameters between lead-exposed and control subjects.…”

Section: Resultsmentioning

confidence: 91%

Clinical, Haematological, and Neurocognitive Findings in Lead-Exposed Workers of a Battery Plant in Iran

Malekirad

Kalantari-Dehaghi

Abdollahi

2013

Archives of Industrial Hygiene and Toxicology

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The aim of this comparative cross-sectional study was to assess neurocognitive impairment, haematological fi ndings, and clinical symptoms of lead exposure among 316 male battery plant workers aged between 20 and 61 years. Compared to 123 matched controls (matching in age and years of work), the exposed workers showed signifi cantly higher mean blood lead level (BLL) and lower haematocrit, haemoglobin, and red blood cell count. Mean BLL signifi cantly correlated with clinical symptoms such as nocturia, increased urination frequency, oedema, drop in deep tendon refl ex, concentration impairment, agitation, headache, depression, abdominal pain, palpitation, fatigue, and diminished sex drive. Workers with clinical disorders had higher BLL and lower haematological parameters. These fi ndings warn that silent toxicological problems caused by lead might go unnoticed by health professionals.

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Section: Resultsmentioning

confidence: 91%

Clinical, Haematological, and Neurocognitive Findings in Lead-Exposed Workers of a Battery Plant in Iran

Malekirad

Kalantari-Dehaghi

Abdollahi

2013

Archives of Industrial Hygiene and Toxicology

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“…These findings might suppose reversibility. In a second study we found no cognitive deficits in subjects who were formerly exposed to lead (Winker et al 2005) compared to a sample of pairwise matched controls. This outcome provides further evidence for reversibility.…”

Section: Introductionmentioning

confidence: 89%

Lead exposure levels and duration of exposure absence predict neurobehavioral performance

Winker

Ponocny‐Seliger

Rüdiger

et al. 2005

Int Arch Occup Environ Health

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“…Among a large cohort of current and former inorganic lead workers studied in Korea, a cross-sectional analysis ( n = 803 workers) (Schwartz et al 2001) and a 3-year longitudinal analysis ( n = 576 workers) (Schwartz et al 2005) found that blood lead concentrations across the approximate range of 20–50 μg/dL were associated with subclinical neurocognitive deficits. Among a small population of former lead workers ( n = 48) and age-matched controls with similar blood lead concentrations (approximately 5 μg/dL in both groups; range, 1.6–14.5 μg/dL; mean age, 39.8 years), increases in current blood lead concentration within the entire study population were correlated with poorer performance on several tests of neurocognitive function but on only one measure was cumulative lead exposure (measured in the workers) associated with poorer performance (Winker et al 2005). …”

Section: Health Effects At Low Dosementioning

confidence: 94%

Recommendations for Medical Management of Adult Lead Exposure

Kosnett

Wedeen

Rothenberg

et al. 2007

Environ Health Perspect

323

253

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Research conducted in recent years has increased public health concern about the toxicity of lead at low dose and has supported a reappraisal of the levels of lead exposure that may be safely tolerated in the workplace. In this article, which appears as part of a mini-monograph on adult lead exposure, we summarize a body of published literature that establishes the potential for hypertension, effects on renal function, cognitive dysfunction, and adverse female reproductive outcome in adults with whole-blood lead concentrations < 40 μg/dL. Based on this literature, and our collective experience in evaluating lead-exposed adults, we recommend that individuals be removed from occupational lead exposure if a single blood lead concentration exceeds 30 μg/dL or if two successive blood lead concentrations measured over a 4-week interval are ≥ 20 μg/dL. Removal of individuals from lead exposure should be considered to avoid long-term risk to health if exposure control measures over an extended period do not decrease blood lead concentrations to < 10 μg/dL or if selected medical conditions exist that would increase the risk of continued exposure. Recommended medical surveillance for all lead-exposed workers should include quarterly blood lead measurements for individuals with blood lead concentrations between 10 and 19 μg/dL, and semiannual blood lead measurements when sustained blood lead concentrations are < 10 μg/dL. It is advisable for pregnant women to avoid occupational or avocational lead exposure that would result in blood lead concentrations > 5 μg/dL. Chelation may have an adjunctive role in the medical management of highly exposed adults with symptomatic lead intoxication but is not recommended for asymptomatic individuals with low blood lead concentrations.

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No cognitive deficits in men formerly exposed to lead

Cited by 15 publications

References 21 publications

Clinical, Haematological, and Neurocognitive Findings in Lead-Exposed Workers of a Battery Plant in Iran

Clinical, Haematological, and Neurocognitive Findings in Lead-Exposed Workers of a Battery Plant in Iran

Lead exposure levels and duration of exposure absence predict neurobehavioral performance

Recommendations for Medical Management of Adult Lead Exposure

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