“…Thus, in cardiac surgery studies with albumin as the control, HES has resulted in platelet depletion and dysfunction, prothrombin time and activated partial thromboplastin time prolongation, and increased postoperative bleeding. ‡ One NCT of 444 patients revealed significant increases in blood product use, as well as postoperative blood loss, in patients receiving HES †References 27,29,34,40,61,62,69,78,80,82,94,103,104. ‡References 3,11,13,15,17,46,48,50,65,92.…”