No clinically relevant effect of Iornoxicam intake on acenocoumarol pharmacokinetics and pharmacodynamics

Abstract

Co-administration of lornoxicam at the upper limit of recommended doses does not alter the pharmocokinetics of the clinically relevant (R)-acenocoumarol or the anticoagulant activity of acenocoumarol. These data clearly differ from the results of previous studies, which showed clinically relevant influences of lornoxicam on warfarin kinetics and of piroxicam on acenocoumarol kinetics.

Facile iron(III) chloride hexahydrate catalyzed synthesis of coumarins

“…[1][2][3][4] They show diverse biological and pharmacological activities ranging from antimicrobial, anti-arrhythmic, antitumor, antifungal, anti-HIV, anti-osteoporosis to anti-inflammatory. [5][6][7][8][9][10][11][12] Apart from their pharmaceutical applications, [13][14] coumarins have been used as additives in foods, perfumes and cosmetics as well as in the preparation of optical brighteners, laser dyes, fluorescent labels and nonlinear optical chromophores. [15][16][17][18][19] The Pechmann reaction 20 is known as one of the most valuable methods for the synthesis of coumarins since it proceeds from simple starting materials, a phenol and a -keto ester, together with an acid catalyst.…”

Molecular first order hyperpolarizability and vibrational spectral investigation of Warfarin sodium

“…The coumarin derivatives are known to have diverse applications as anticoagulants, spasmolytics, anticancer drugs or as plant growth regulating agents [1][2][3][4]. Their complexation ability in respect to different metal ions has been studied and discussed widely in a considerable number of investigations [5][6][7][8][9].…”

DFT modeling and spectroscopic study of metal–ligand bonding in La(III) complex of coumarin-3-carboxylic acid

“…The coumarin derivatives are known to have diverse applications as anticoagulants, spasmolytics, anticancer drugs or as plant growth regulating agents [1][2][3][4]. Their complexation ability in respect to different metal ions has been studied and discussed widely in a considerable number of investigations [5][6][7][8][9].…”