No causal association between pneumoconiosis and three inflammatory immune diseases: a Mendelian randomization study
Yu-Jie Du,
Zhang-Wei Lu,
Kai-Di Li
et al.
Abstract:ObjectivesTo investigate the causal relationships between pneumoconiosis and rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and gout.MethodsThe random-effects inverse variance weighted (IVW) approach was utilized to explore the causal effects of the instrumental variables (IVs). Sensitivity analyses using the MR-Egger and weighted median (WM) methods were did to investigate horizontal pleiotropy. A leave-one-out analysis was used to avoid the bias resulting from single-nucleotide polymorphisms … Show more
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