No-carrier-added synthesis of aliphatic and aromatic radioselenoethers via selenocyanates

Blum, Till; Neumaier, Bernd; Coenen, Heinz H.

doi:10.1016/s0969-8051(03)00004-0

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…This pathway offers the advantage of generating both aliphatic and aromatic radioselenoethers by using appropriate alkyl or aryl magnesium (Grignard) or lithium compounds. 166 These nca radioselenation methods, successfully applied for the synthesis of nca [ 75 Se]selenomethionine and nca homocysteine[ 75 Se]selenolactone, 163,165 were studied to synthesize selenium-containing radiotracers potentially applicable in PET studies when labelled with 73 Se.…”

Section: Labelling Methods For Radioseleniummentioning

confidence: 99%

“…After separation, the alkyl radioselenocyanates reacted with organic lithium or Grignard compounds to asymmetric 75 Se‐labelled selenoethers with an RCY of 9% to 55%, depending on the type of substituent. This pathway offers the advantage of generating both aliphatic and aromatic radioselenoethers by using appropriate alkyl or aryl magnesium (Grignard) or lithium compounds …”

Section: Selenium‐73mentioning

confidence: 99%

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Labelling with positron emitters of pnicogens and chalcogens

Neumaier

2017

Labelled Comp Radiopharmac

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The increasing importance of the positron emission tomography (PET) in clinical diagnosis led to the development of a multitude of radiotracers labelled with positron‐emitting radionuclides of groups 15 (pnicogens) and 16 (chalcogens) of the periodic table of elements. The positron emitters of the endogenous occurring elements nitrogen, phosphorus, oxygen, and sulphur are characterized by very short half‐lives compared with the most commonly used PET radionuclides carbon‐11 or fluorine‐18. Therefore, the potential of their synthesis and possible applications in PET is challenging and limited. On the other hand, the nonstandard positron emitters arsenic‐72, arsenic‐74, and selenium‐73 have half‐lives in the range of hours to days and, thus, are of interest for PET studies of processes with long biological half‐lives, but novel methods have to be developed for their application, especially in the no‐carrier‐added state. This review summarizes recent research concerning the positron emitters of pnicogens and chalcogens for radiolabelling applications.

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Section: Labelling Methods For Radioseleniummentioning

confidence: 99%

Section: Selenium‐73mentioning

confidence: 99%

Labelling with positron emitters of pnicogens and chalcogens

Neumaier

2017

Labelled Comp Radiopharmac

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“…radioselenium compounds: Starting from n.c.a. methyl[ 75 Se]selenide, which is available using sulfur as non‐isotopic carrier, alkylation of disubstituted radio selenoureas and conversion of alkyl[ 75 Se]selenocyanates with alkyl and aryl lithium or Grignard compounds were realized . Only the latter method allows the synthesis of aromatic radioselenoethers.…”

Section: Introductionmentioning

confidence: 99%

No‐carrier‐added labeling of the neuroprotective Ebselen with selenium‐73 and selenium‐75

Helfer

Neumaier

Humpert

et al. 2015

Labelled Comp Radiopharmac

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Selenium-73 is a positron emitting non-standard radionuclide, which is suitable for positron emission tomography. A copper-catalyzed reaction allowed no-carrier-added labeling of the anti-inflammatory seleno-organic compound Ebselen with (73) Se and (75) Se under addition of sulfur carrier in a one-step reaction. The new authentically labeled radioselenium molecule is thus available for preclinical evaluation and positron emission tomography studies.

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Expanding PET-applications in life sciences with positron-emitters beyond fluorine-18

Coenen

Neumaier

2021

Nuclear Medicine and Biology

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No-carrier-added synthesis of aliphatic and aromatic radioselenoethers via selenocyanates

Cited by 4 publications

References 20 publications

Labelling with positron emitters of pnicogens and chalcogens

Labelling with positron emitters of pnicogens and chalcogens

No‐carrier‐added labeling of the neuroprotective Ebselen with selenium‐73 and selenium‐75

Expanding PET-applications in life sciences with positron-emitters beyond fluorine-18

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