No associations of CTLA-4 and ICAM-1 polymorphisms with psoriasis in the Korean population

Lack of association between cytotoxic T-lymphocyte antigen-4+49A/G polymorphism and psoriasis and vitiligo: A meta-analysis of case–control studies

“…We found no significant association between CTLA-4 + 49A/G polymorphism and psoriasis in our overall analysis. In fact, only one case-control study (Hao et al, 2003) has reported increased risk of psoriasis in allele G carriers, whereas all other casecontrol studies showed no association between them (Kim et al, 2003;Tsunemi et al, 2003;Luszczek et al, 2008;Fernandez-Mestre et al, 2009;Muto et al, 2011), in line with our findings. There are some possible reasons for the lack of a significant effect of the CTLA-4 + 49A/G polymorphism on psoriasis.…”

“…All 14 studies applied polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for genotyping. The distribution of genotypes in the controls was consistent with HWE in almost all studies, with the exception of two studies for psoriasis (Kim et al, 2003;Tsunemi et al, 2003) and one study for vitiligo (Blomhoff et al, 2005). The characteristics of the included studies are shown in Table 1.…”

“…Although the efforts to contact the corresponding authors failed, two studies without sufficient information were included (Blomhoff et al, 2005;Birlea et al, 2009). (Hao et al, 2003) which may be the major source of the heterogeneity, and under (C) GG + GA vs. AA model after exclusion of non-HWE studies (Kim et al, 2003;Tsunemi et al, 2003) and one study (Hao et al, 2003) which may be the major source of the heterogeneity. Pooled ORs and 95% CIs were derived from the fixed effects model.…”

“…Subgroup analysis based on ethnicity showed similar results. When stratifying the data by HWE or/and heterogeneity, no significant correlation was found, except for the dominant (OR = 0.69, 95% CI = 0.51-0.93, I 2 = 0.0%) and additive (OR = 0.69, 95% CI = 0.48-0.98, I 2 = 0.0%) models which did not include one study (Hao et al, 2003) that was likely the major source of heterogeneity, and the dominant model (OR = 0.68, 95% CI = 0.48-0.98, I 2 = 0.0%) which did not include non-HWE studies (Kim et al, 2003;Tsunemi et al, 2003) and Hao et al study (Hao et al, 2003) (Table 2 and Fig. 3).…”

“…Furthermore, individuals with the G/G genotype at position +49 show higher proliferation and Studies further excluded (n = 5): Not case-control study (n = 1) Reported duplicated data (n = 2) Not provided relevant data (n = 1) Not focus on the polymorphism of rs231775 (n = 1) 1 contained data on two different groups activation of T cells than the A/A genotype (Kouki et al, 2000;Maurer et al, 2002). Some studies have looked for a possible association between CTLA-4 + 49A/G polymorphism and psoriasis (Hao et al, 2003;Kim et al, 2003;Tsunemi et al, 2003;Luszczek et al, 2008;Fernandez-Mestre et al, 2009;Muto et al, 2011) or vitiligo (Blomhoff et al, 2005;Gao et al, 2005;Tang, 2007;Birlea et al, 2009;Pehlivan et al, 2009;Deeba et al, 2010;Dwivedi et al, 2011), but the findings have been (Hao et al, 2003) which may be the major source of the heterogeneity. b Statistically significant result.…”