No association of neurotensin receptor 1 gene polymorphisms with coping styles in healthy Chinese-Han individuals

Zhang, Bo; Ma, Hongyu; Huang, Yinglin; Li, Jingying; Wang, Yuan; Qiu, Jin; Zhao, Xiaofeng; Zhu, Gang

doi:10.1097/ypg.0b013e32836130c4

Cited by 2 publications

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“…Polymerase chain reaction (PCR) amplification of gene fragments containing the SNPs and subsequent restriction fragment length polymorphism analysis were carried out as described in our previous studies [28,29,30]. Genomic DNA was extracted from EDTA-treated peripheral venous blood by standard techniques using a DNA extraction kit (Wizard® Genomic DNA purification kit, Promega, Beijing, PR China).…”

Section: Methodsmentioning

confidence: 99%

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Neurotensin Receptor 1 Gene Polymorphisms Are Associated with Personality Traits in Healthy Chinese Individuals

Huang

Zhang

et al. 2013

Neuropsychobiology

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Aims: Neurotensin receptor 1 (NTR1) is a neurotensin (NT) receptor subtype with a high affinity for NT. NT and NTR1 signaling are involved in modulating the dopamine system. Individual variations in the dopamine system have been demonstrated to determine certain dimensions of personality, but no studies have thus far investigated the involvement of the NTR1 in the biological determination of personality. We therefore examined this link in a Chinese Han population. Methods: We genotyped 3 single nucleotide polymorphisms (SNPs) (rs6090453C/G, rs6011914C/G, and rs2427422A/G) of the NTR1 gene and collected the data about the personality traits of novelty seeking (NS), harm avoidance (HA), and reward dependence (RD), as well as their subscales (measured by the Tridimensional Personality Questionnaire), in 575 healthy Chinese Han subjects. Then we examined the association between the 3 NTR1 gene polymorphisms and each personality trait. Results: There were significant differences in the HA2, HA3 and RD1 scores between rs6090453C/G genotypes (F = 3.425, 5.651, 4.054, p = 0.033, 0.004, 0.018, respectively), in the HA2 and total RD scores between rs6011914C/G genotypes (F = 4.080, 3.712, p = 0.017, 0.025, respectively), and in the total RD (χ² = 7.301, p = 0.026) and RD3 (F = 4.119, p = 0.017) scores between the rs2427422A/G genotypes. There were significant male-specific differences in the RD1 scores between the rs6090453C/G genotypes (F = 3.334, p = 0.037), in the total HA (F = 3.043, p = 0.049), HA2 (F = 4.472, p = 0.012) and RD3 (χ² = 6.997, p = 0.030) scores between the rs6011914C/G genotypes, and in the HA2 (F = 3.177, p = 0.043), total RD (χ² = 7.032, p = 0.030), and RD3 (F = 4.563, p = 0.011) scores between the rs2427422A/G genotypes. We also demonstrated a significant female-specific difference in the total RD scores between the rs6011914C/G genotypes (F = 3.677, p = 0.026). There was no significant difference in the total NS and subscale scores between the genotypes of all 3 SNPs (all p > 0.05). Conclusions: The variations in the NTR1 gene were involved in the biological mechanisms of HA and RD personality traits; however, the effect is influenced by gender.

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Section: Methodsmentioning

confidence: 99%

“…Here we investigated this link in a large healthy Chinese Han population. The 3 SNPs investigated (rs6090453, rs6011914, and rs2427422) were chosen due to our previous research into schizophrenia [28], anxiety [29], and copying style [30]. …”

Section: Introductionmentioning

confidence: 99%

Neurotensin Receptor 1 Gene Polymorphisms Are Associated with Personality Traits in Healthy Chinese Individuals

Huang

Zhang

et al. 2013

Neuropsychobiology

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“…The results would provide empirical evidence for the biological factors of defense mechanism. The three SNPs investigated (rs6090453, rs6011914, and rs2427422, Figure 1 ) were selected due to our previous research on personality traits ( 22 , 34 ), copying styles ( 35 ), anxiety ( 36 ), schizophrenia ( 37 ), and alcohol dependence ( 38 ).…”

Section: Introductionmentioning

confidence: 99%

Association of Neurotensin Receptor 1 Gene Polymorphisms With Defense Mechanisms in Healthy Chinese

Zhang³

et al. 2021

Front. Psychiatry

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Aims: In the central nerve system, neurotensin (NT), and neurotensin receptor 1 (NTR1) modulate the dopamine system. Gene variations in the dopamine system have been demonstrated to influence certain defense mechanisms, but no studies have investigated possible effect of NTR1 gene polymorphisms in the biological determination of these defenses. The present study therefore examined this link.Methods: In 412 healthy Han Chinese, single nucleotide polymorphisms rs6090453C/G, rs6011914C/G, and rs2427422A/G of the NTR1 gene were genotyped, and the defense mechanisms were measured by the self-reporting Defense Style Questionnaire 88.Results: Significant male-specific differences in the projective identification among the rs6090453 genotypes (p = 0.003); in the intermediate defense, reaction formation, and projective identification among the rs6011914 genotypes (p = 0.011, 0.010, and 0.011, respectively); and in the projective identification among the rs2427422 genotypes (p = 0.005) were found when the level of significance was adjusted by the Bonferroni correction. There was no significant difference in any of the defense scores among genotypes of any single nucleotide polymorphism in the total cohort or female subjects (all p > 0.017). The distributions of genotypes between the low and high score subgroups showed significant differences in the rs2427422 genotype distributions for help-rejecting complaining, regression, and projective identification (p = 0.010, 0.022, and 0.044, respectively). Significant differences were found between males and females in 10 defense mechanisms (all P < 0.05).Conclusions: The gene variations in the NTR1 polymorphisms were involved in the biological mechanisms of intermediate defense mechanisms, and this effect was influenced by sex.

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No association of neurotensin receptor 1 gene polymorphisms with coping styles in healthy Chinese-Han individuals

Cited by 2 publications

References 1 publication

Neurotensin Receptor 1 Gene Polymorphisms Are Associated with Personality Traits in Healthy Chinese Individuals

Neurotensin Receptor 1 Gene Polymorphisms Are Associated with Personality Traits in Healthy Chinese Individuals

Association of Neurotensin Receptor 1 Gene Polymorphisms With Defense Mechanisms in Healthy Chinese

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