No association of FCRN promoter VNTR polymorphism with the rate of maternal–fetal IgG transfer

Freiberger, Tomáš; Ravčuková, Barbora; Grodecká, Lucie; Kuřecová, Barbora; Jarkovský, Jiří; Bartoňková, Dana; Thon, Vojtěch; Litzman, Jiří

doi:10.1016/j.jri.2010.04.002

Cited by 11 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…-flanking region, as was the case in Caucasian subjects reported previously. 8) Although a recent study showed that no significant impact was observed in the rates of maternal-fetal IgG transfer, 21) VNTR3 is known to be associated with 1.66-fold higher transcriptional activity than VNTR2 in vitro. In addition, monocytes with VNTR3/3 showed increased binding of IgG compared to those with 2/3.…”

Section: Discussionmentioning

confidence: 97%

Genetic Polymorphisme of FCGRT Encoding FcRn in a Japanese Population and Their Functional Analysis

Ishii‐Watabe

Saito

Suzuki

et al. 2010

Drug Metabolism and Pharmacokinetics

View full text Add to dashboard Cite

Neonatal Fc receptor (FcRn) plays an important role in regulating IgG homeostasis in the body. Changes in FcRn expression levels or activity caused by genetic polymorphisms of FCGRT, which encodes FcRn, may lead to interindividual differences in pharmacokinetics of therapeutic antibodies. In this study, we sequenced the 5'-flanking region, all exons and their flanking regions of FCGRT from 126 Japanese subjects. Thirty-three genetic variations, including 17 novel ones, were found. Of these, two novel non-synonymous variations, 629G>A (R210Q) and 889T>A (S297T), were found as heterozygous variations. We next assessed the functional significance of the two novel non-synonymous variations by expressing wild-type and variant proteins in HeLa cells. Both variant proteins showed similar intracellular localization as well as antibody recycling efficiencies. These results suggested that at least no common functional polymorphic site with amino acid change was present in the FCGRT of our Japanese population.

show abstract

Section: Discussionmentioning

confidence: 97%

Genetic Polymorphisme of FCGRT Encoding FcRn in a Japanese Population and Their Functional Analysis

Ishii‐Watabe

Saito

Suzuki

et al. 2010

Drug Metabolism and Pharmacokinetics

View full text Add to dashboard Cite

show abstract

“…Another study investigated whether such VNTR were associated with risk for glomerular nephritis in Chinese and found no such correlation [70]. Finally, a more recent study that evaluated whether these VNTRs influence maternofetal transfer of IgG and found no such effect [71]. Genome wide association studies provide an unbiased strategy to evaluate whether allelic variations contribute meaningfully to the disease studied.…”

Section: Is There Functionally-relevant Genetic Variation In Fcrn?mentioning

confidence: 99%

Clinical Ramifications of the MHC Family Fc Receptor FcRn

Roopenian

Sun

2010

J Clin Immunol

View full text Add to dashboard Cite

show abstract

“…Calves homozygous for 1 of the 8 haplotypes (B2M 2.2) were at increased risk of failure of passive IgG transfer. However, Freiberger et al (2010) found no association between the FcRn promoter polymorphism, both maternal FcRn and of fetal FcRn, and the rate of maternal-fetal IgG transfer by analyzing 103 single fetal samples and 103 paired maternal and fetal samples collected from the umbilical cord blood of full-term neonates.…”

Section: Dna Polymorphism Analysis Of the Fcgrt Genementioning

confidence: 93%

Analysis of Fcgrt gene polymorphism in indigenous Chinese sheep and its association with colostrum IgG concentration

et al. 2015

View full text Add to dashboard Cite

ABSTRACT. The neonatal Fc receptor (FcRn) plays an important role in regulating IgG homeostasis in the body and passive protection to the offspring. Changes in FcRn expression levels caused by genetic polymorphisms of Fcgrt, which encodes FcRn, may lead to interindividual differences in colostrum IgG levels in sheep. In this study, we sequenced the FcRn partial heavy chain from 179 sheep from Xinjiang Province, China, and detected the differences in colostrum IgG levels and Fcgrt genotypes to identify the correlation between the Fcgrt genotype and colostrum IgG levels in 4 sheep breeds. The DNA sequencing of a 680-bp fragment of the Fcgrt gene revealed various patterns depending on the single-strand conformation in the Suffolk breed. Sequencing analysis revealed a total of 3 patterns, AA, BB, AB, in this fragment, among which the absence of AB and BB genotype acted as a marker for breed identification and characterization, while the AA genotype was shared by Suffolk and 3 other breeds. The only allele found in all 4 breeds was allele A, indicating that natural selection may be favoring the AB and BB genotypes in general and B allele in particular, as the colostrum IgG concentration was relatively higher in the Suffolk breed compared to the other 3 breeds.

show abstract

No association of FCRN promoter VNTR polymorphism with the rate of maternal–fetal IgG transfer

Cited by 11 publications

References 8 publications

Genetic Polymorphisme of FCGRT Encoding FcRn in a Japanese Population and Their Functional Analysis

Genetic Polymorphisme of FCGRT Encoding FcRn in a Japanese Population and Their Functional Analysis

Clinical Ramifications of the MHC Family Fc Receptor FcRn

Analysis of Fcgrt gene polymorphism in indigenous Chinese sheep and its association with colostrum IgG concentration

Contact Info

Product

Resources

About