No association between triple‑negative breast cancer and prognosis of patients receiving breast‑conserving treatment

Mu, Liancai; Liu, Yuxiang; Xiao, Meng; Liu, Weise; Miao, Liyun; Wang, Xin

doi:10.3892/ol.2017.7251

Cited by 3 publications

(3 citation statements)

References 39 publications

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“…Among our patients, 96.9% were administered chemotherapy, including 54.9% administered neoadjuvant chemotherapy as a result of advanced stage or poor prognosis. Neoadjuvant chemotherapy was not beneficial to PABC patient survival in our study, but it improved the rate of BCS (22.5%) in PABC compared to approximately 10% in non‐PABC patients in China . As all patients who received chemotherapy were in postpartum, we could not evaluate the effect of chemotherapeutics on the pregnancy and fetus, but most of the previous literature has shown that chemotherapy can be safely used during the second and third trimesters .…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics, diagnosis, and prognosis of pregnancy‐associated breast cancer

et al. 2019

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Background The aim of this study was to evaluate the characteristics, diagnosis, prognosis, and effective treatment modalities of pregnancy‐associated breast cancer (PABC). Methods From 1 January 2005 to 31 December 2015, 142 patients with PABC were identified in the Cancer Institute and Hospital of Tianjin Medical University database. The clinicopathological features, treatment methods, and outcomes were retrospectively evaluated. Results The median age at diagnosis was 30 years. All patients presented with a palpable mass in the breast. The sensitivity of ultrasound and mammography in PABC diagnosis was 86% and 83.3%, respectively, which increased to 91.3% when a combination of mammography and ultrasound was used. The median tumor size was 5.5 cm, and 63.1% of patients had associated axillary lymph node metastases. The proportions of ER negative, PR negative and HER2 positive were 45.7%, 45.7% and 30%, respectively. The five‐year overall survival (OS) and disease‐free survival (DFS) rates were 76.8% and 63.5%, respectively. According to univariate analysis, T stage, N stage, and HER2 status were significant prognostic factors for OS and DFS. The time interval between the onset of the first symptom and the first meeting with a health professional was also significant for OS. Multivariate analysis showed that T stage and HER2 status were independent prognostic risk factors for OS and DFS. Conclusion PABC is an aggressive form of breast cancer associated with advanced stage at diagnosis. Despite the existing difficulties in diagnosis, imaging examinations are indispensable. Early diagnosis and multidisciplinary therapy, including anti‐HER2 targeted therapy, may be important to improve prognosis.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics, diagnosis, and prognosis of pregnancy‐associated breast cancer

et al. 2019

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“…Study of Mu et al on 20-80 years population with early stage cancer showed the average age of 45 years. 10 In the United States, breast cancer were mostly found in average of 40-70 years, with tumor size of 2 to 4.9 cm at the first diagnosis. 11 While as in United Kingdom, the first diagnosed is at 60-70 years, with tumor size of 2 to 5 cm.…”

Section: Discussionmentioning

confidence: 99%

Triple Diagnostic Accuracy on Early Stage Breast Cancer at Cipto Mangunkusumo Hospital and Persahabatan Hospital

Kartini

Megatia

Darmiati

et al. 2018

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Introduction. Breast cancer is the most common cancer in Indonesia with incidence rate 40.3 per 100.000 women and mortality rate 16.6 per 100.000 women. On early stage, the decision for operative procedure (i.e. mastectomy) requires intraoperative frozen section to assess malignancy; which is mostly unavailable in secondary hospitals. The triple diagnostic (TD) test consists of physical examination, breast ultrasonography and fine needle aspiration biopsy is an accurate and simple preoperative diagnostic method that may solve the problem. The study aimed to find out conformance of the triple diagnostic to histopathology findings in those with breast lump where the malignancy was suspected. Method. A study of diagnostic accuracy conducted enrolling subjects with suspected malignant breast lump managed in dr Cipto Mangunkusumo General Hospital (RSCM) and Persahabatan Hospital (RSP) in period of February 2016 to August 2017 who met the criteria: those underwent preoperative triple diagnostic, intraoperative frozen section and histopathology examination. The conformance of TD and frozen section were compared to histopathology findings. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were the focuses of the study. Results. There were 33 subjects enrolled (prevalence of 4.3%), mean age of 49.6 years ± 10.9, were above 40 years (78.8%). Tumor size of 2-5 cm found in 63.6% subjects, and the most histopathology finding was invasive carcinoma (84.8%). Frozen section showed sensitivity of 96.8%, specificity of 100%, PPV of 100%, NPV of 66.7% and accuracy of 97.0%. TD showed sensitivity of 77.4%, specificity of 100%, PPV of 100%), NPV of 22.2% and accuracy of 78.8% (p = 0.016). Conclusion. Triple diagnostic reaches up to 78% accuracy on early stage breast cancer may be used secondary hospital in Indonesia whenever frozen section is unavailable.

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“…It was even found that BCT had a survival benefit for TNBC compared with total mastectomy ( 25 ). This might be due to the fact that most reviews and observational studies focused on the prognostic impact of BCT for TNBC versus other molecular subtypes of breast cancer, and therefore only included patients who received BCT ( 2 , 20 , 26 , 27 ); whereas other studies looked at the effect of different surgical interventions on prognosis and included patients who had undergone total mastectomy ( 18 , 25 ). Therefore, it is the current consensus that TNBC is not contraindicated to BCT ( 21 ).…”

Section: Introductionmentioning

confidence: 99%

Determining prognostic factors and optimal surgical intervention for early-onset triple-negative breast cancer

et al. 2022

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BackgroundFew studies have focused specifically on prognostic factors and optimal surgical intervention for early-onset triple-negative breast cancer (eTNBC), which is characterized by high malignancy and poor prognosis.MethodsWe performed a cohort study with a median follow-up of 31 months using Surveillance, Epidemiology, and End Results (SEER) data of patients diagnosed with stages I–III eTNBC between 2010 and 2016. In addition, we collected cases between 2006 and 2016 from our center as an external validation set. Clinical features, pathologic characteristics and oncologic outcomes were analyzed. Prognostic factors for overall survival (OS) and breast cancer-specific survival (BCSS) were determined by Cox proportional hazards analyses and were incorporated into the prognostic nomogram. Subgroup analysis based on propensity score matching method was conducted to explore the subset of patients that would benefit from breast-conserving therapy (BCT).ResultsBased on SEER dataset, patients with eTNBC were more likely to undergo mastectomy than BCT. On multivariable analysis, patients with better survival outcomes were those not married, uninsured, had higher T and N stage, and had histological type of mixed invasive ductal and lobular carcinoma. The prognostic nomogram based on these variables successfully predicted the 3- and 5-year BCSS (C-index in training cohort, 0.774; in validation cohort from SEER, 0.768; in validation cohort from our center, 0.723). Subgroup analysis illustrated that patients with T1N0M0 or T2-4N+M0 tumors who underwent BCT achieved longer overall survival than those who underwent mastectomy (for T1N0M0, P = 0.022; for T2-4N+M0, P = 0.003); however, the type of surgery did not influence OS among patients with T1N+M0 or T2-4N0M0 tumors (for T1N+M0, P = 0.305; for T2-4N0M0, P = 0.317).ConclusionsThe prognosis of patients with eTNBC is mainly affected by marital status, insurance status, T stage, N stage and histological type. The prognostic nomogram based on these factors is quite reliable. Subgroup analysis suggested that BCT may be a superior option for patients with eTNBC, especially those with T1N0M0 and T2-4N+M0 tumors.

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No association between triple‑negative breast cancer and prognosis of patients receiving breast‑conserving treatment

Cited by 3 publications

References 39 publications

Clinicopathological characteristics, diagnosis, and prognosis of pregnancy‐associated breast cancer

Clinicopathological characteristics, diagnosis, and prognosis of pregnancy‐associated breast cancer

Triple Diagnostic Accuracy on Early Stage Breast Cancer at Cipto Mangunkusumo Hospital and Persahabatan Hospital

Determining prognostic factors and optimal surgical intervention for early-onset triple-negative breast cancer

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