No Association Between the Microsatellite Polymorphism (TTTTA) n in the Promoter of the CYP11A Gene and Ovarian Hyperstimulation Syndrome

Ferk, Polonca; Geršak, Ksenija; Teran, Nataša

doi:10.1007/s10815-005-9009-x

Cited by 3 publications

(3 citation statements)

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“…Frequency of 4R allele increased with degree of latitude north ( p < 0.05), while frequency of 8R allele was inversely correlated with latitude ( p < 0.001). This trend was confirmed by pooling our data with literature data (Greece, United Kingdom, and Slovenia) (Diamanti-Kandarakis et al, 2000;Gaasenbeek et al, 2004;Ferk et al, 2006).…”

Section: Discussionsupporting

confidence: 86%

“…The first study carried out in non-European populations by Wang et al (2006) revealed an association between 6R=6R genotype and Chinese women with greater body mass index (BMI) in polycystic ovary syndrome (PCOS). Ferk et al (2006) found a lack of association between (TTTTA)n pentanucleotide and Slovenic women with high risk of ovarian hyperstimulation syndrome (OHSS), while Zheng et al (2004) concluded that 8 repeat (8R) allele of this polymorphism may be an important susceptibility factor for breast cancer risk in Chinese women. Until now, the association of (TTTTA)n repeat in hyperandrogenism and in related diseases remains unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Alleles 4R and 8R showed significant results with degrees of latitude north ( p < 0.05, r ¼ 0.697, and p < 0.01, r ¼ À 0.902, respectively). Using frequencies of populations from United Kingdom, Greece, Slovenia, and Finland (Diamanti-Kandarakis et al, 2000;Gaasenbeek et al, 2004;Ferk et al, 2006) (Table 3), we calculated correlation with latitude north. For allele 4R, we confirmed the trend observed of our 10 populations analyzed, with a significant correlation with degree of latitude north ( p < 0.01, r ¼ 0.740).…”

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Frequencies of Promoter Pentanucleotide (TTTTA)n ofCYP11AGene in European and North African Populations

et al. 2008

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The present work attempts to determine the distribution of CYP11A (TTTTA)n genotype and allele frequencies in 10 European and North African populations. This polymorphism has been associated with hyperandrogenism by several association studies. To our knowledge, this is the first study investigating the ethnic variation of this polymorphism. DNA was extracted from 868 whole-blood samples with the standard phenol-chloroform technique, and PCR reactions were carried out using fluorescent primers as described previously. PCR products were analyzed by an ABI 3,730 DNA Analyzer. A total of six alleles were identified, ranging from 220 bp (4 repeats [4R]) to 250 bp (10R). The most frequent allelic fragment size in all populations was 4R, with frequencies ranging from 47.9% (Sicily) to 62.8% (Tuscany and Germany). Allelic frequencies showed high heterogeneity between analyzed populations. We detected a significant gradient for alleles 4R and 8R. In this study, we report the allele frequency distribution of CYP11A (TTTTA)n showing a north-south geographic gradient. This result could be useful for epidemiological studies about hyperandrogenism.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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