No association between the COMT Val158Met polymorphism and the long‐term clinical response in obsessive–compulsive disorder in the Japanese population

Umehara, Hiroki; Numata, Shusuke; Tajima, Atsushi; Kinoshita, Makoto; Nakaaki, Shutaro; Imoto, Issei; Sumitani, Satsuki; Ohmori, Tetsuro

doi:10.1002/hup.2485

Cited by 9 publications

(4 citation statements)

References 32 publications

(60 reference statements)

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“…A recent study detected significant associations between SLC1A1 rs2228622 and rs3780413 with fluvoxamine response (Abdolhosseinzadeh et al, 2019). Five studies, investigating the dopaminergic DRD2, DRD4, COMT, and MAOA, have been performed, but they were all negative (Zhang et al, 2004;Miguita et al, 2011;Vulink et al, 2012;Viswanath et al, 2013;Umehara et al, 2015) except for COMT rs4680 Met/Met genotype with citalopram response (Vulink et al, 2012). Several studies conducted in other candidate genes have detected inconsistent results (Zai et al, 2014).…”

Section: Pharmacogenetics Of Antidepressants In Obsessivecompulsive D...mentioning

confidence: 99%

New insights and perspectives on the genetics of obsessive-compulsive disorder

Zai

Barta

Cath

et al. 2019

Psychiatric Genetics

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Psychiatric genetic research has exploded in search of polygenic risk factors over the past decade, but because of the complexity and heterogeneity of mental illnesses, using the current understanding of the genome has not reached the conclusion of finding a cause for psychiatric disorders. Obsessive-compulsive disorder is a relatively common and often debilitating neuropsychiatric disorder that has not been the primary focus in psychiatric research. Clinicians and researchers who have dedicated to investigate the genetics of obsessive-compulsive disorder have detected a strong genetic involvement. This review will provide an update and a new perspective on the current understanding of the genetics of obsessivecompulsive disorder, which includes epidemiological data, family and twins studies, candidate gene studies, genomewide association studies, copy-number variants, imaging genetics, epigenetics, and gene-environment interaction.

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Section: Pharmacogenetics Of Antidepressants In Obsessivecompulsive D...mentioning

confidence: 99%

New insights and perspectives on the genetics of obsessive-compulsive disorder

Zai

Barta

Cath

et al. 2019

Psychiatric Genetics

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“…Ninety-six OCD patients were recruited from Tokushima University Hospital in Japan, as described in detail in a separate study [ 10 ]. All subjects who participated in this study were of Japanese origin, and 10 subjects had not taken any psychotropic drugs.…”

Section: Methodsmentioning

confidence: 99%

Calcium Signaling Pathway Is Associated with the Long-Term Clinical Response to Selective Serotonin Reuptake Inhibitors (SSRI) and SSRI with Antipsychotics in Patients with Obsessive-Compulsive Disorder

et al. 2016

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BackgroundSelective serotonin reuptake inhibitors (SSRI) are established first-line pharmacological treatments for obsessive-compulsive disorder (OCD), while antipsychotics are used as an augmentation strategy for SSRI in OCD patients who have either no response or a partial response to SSRI treatment. The goal of the present study was to identify genetic variants and pathways that are associated with the long-term clinical response of OCD patients to SSRI or SSRI with antipsychotics.MethodsWe first performed a genome-wide association study of 96 OCD patients to examine genetic variants contributing to the response to SSRI or SSRI with antipsychotics. Subsequently, we conducted pathway-based analyses by using Improved Gene Set Enrichment Analysis for Genome-wide Association Study (i-GSEA4GWAS) to examine the combined effects of genetic variants on the clinical response in OCD.ResultsWhile we failed to detect specific genetic variants associated with clinical responses to SSRI or to SSRI with an atypical antipsychotic at genome-wide levels of significance, we identified 8 enriched pathways for the SSRI treatment response and 5 enriched pathways for the treatment response to SSRI with an antipsychotic medication. Notably, the calcium signaling pathway was identified in both treatment responses.ConclusionsOur results provide novel insight into the molecular mechanisms underlying the variability in clinical response to SSRI and SSRI with antipsychotics in OCD patients.

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“…Most of these samples were used in our previous study. 26 The control group comprised 2,027 volunteers (855 males and 1,172 females; mean age: 38.7±13.3 years) recruited from hospital staff, students, and company employees who were documented to be free from psychiatric problems with no past history of mental illness. All of them were of Japanese descent.…”

Section: Methodsmentioning

confidence: 99%

No association between BDNFVal66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population

Umehara

Numata

Kinoshita

et al. 2016

NDT

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AimBrain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family, and it promotes the development and function of dopaminergic and serotonergic neurons. The Met allele of the BDNF Val66Met polymorphism is associated with a decrease in activity-dependent secretion of BDNF compared with the Val allele, and a number of studies have provided evidence for the association between this polymorphism and obsessive-compulsive disorder (OCD). The purpose of this study was to investigate whether this functional variant of the BDNF gene is associated with OCD and treatment response in patients with OCD in the Japanese population.MethodsWe first performed a case–control association study between the BDNF Val66Met polymorphism and OCD (175 cases and 2,027 controls). Then, we examined an association between this polymorphism and treatment response in 96 patients with OCD.ResultsWe found no significant association between the Met allele and OCD risk or between the Met allele and treatment responses to selective serotonin reuptake inhibitors or serotonin reuptake inhibitor with an atypical antipsychotic (P>0.05).ConclusionOur results suggest that the BDNF Val66Met polymorphism may not be associated as a risk factor for developing OCD or with therapeutic response in patients with OCD in the Japanese population.

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No association between the COMT Val158Met polymorphism and the long‐term clinical response in obsessive–compulsive disorder in the Japanese population

Abstract: The present case-control/pharmacogenetic study did not provide clear evidence that the COMT Val158Met polymorphism is a predictor of OCD or of OCD patients' clinical responses.

Cited by 9 publications

References 32 publications

New insights and perspectives on the genetics of obsessive-compulsive disorder

New insights and perspectives on the genetics of obsessive-compulsive disorder

Calcium Signaling Pathway Is Associated with the Long-Term Clinical Response to Selective Serotonin Reuptake Inhibitors (SSRI) and SSRI with Antipsychotics in Patients with Obsessive-Compulsive Disorder

No association between BDNFVal66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population

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No association between the COMT Val158Met polymorphism and the long‐term clinical response in obsessive–compulsive disorder in the Japanese population

Abstract: The present case-control/pharmacogenetic study did not provide clear evidence that the COMT Val158Met polymorphism is a predictor of OCD or of OCD patients' clinical responses.

Cited by 9 publications

References 32 publications

New insights and perspectives on the genetics of obsessive-compulsive disorder

New insights and perspectives on the genetics of obsessive-compulsive disorder

Calcium Signaling Pathway Is Associated with the Long-Term Clinical Response to Selective Serotonin Reuptake Inhibitors (SSRI) and SSRI with Antipsychotics in Patients with Obsessive-Compulsive Disorder

No association between BDNFVal66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese&nbsp;population

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No association between BDNFVal66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population