No association between SNP309 promoter polymorphism in the MDM2 and cervical cancer in a study from northeastern Brazil

Meissner, Rosely de Vasconcellos; Barbosa, Rodrigo Niskier Ferreira; Fernandes, José Veríssimo; Galvão, Tatiana Medeiros; Galvão, Ana Flávia Oliveira; Oliveira, Gustavo Henrique de Medeiros

doi:10.1016/j.cdp.2007.09.001

Cited by 23 publications

(10 citation statements)

References 16 publications

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“…SNP309 occurs at a relatively high frequency in the general population and has been shown to be associated with accelerated tumorigenesis and the timing of cancer onset [24–27]. However, there have been very few reports on the correlation between SNP of MDM2 gene and cervical cancer susceptibility [28]. …”

Section: Mdm2-snp309mentioning

confidence: 99%

“…Recently, Meissner Rde et al [28] tested the hypothesis that this functional variant in the MDM2 promoter was associated with either risk or early age diagnosis of cervical cancer in a Brazilian population. A primer-introduced restriction analysis PCR assay was used to genotype the MDM2-SNP309 of 72 cervical carcinoma patients and 100 healthy women.…”

Section: Mdm2-snp309mentioning

confidence: 99%

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Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis

Nunobiki

Ueda

Toji

et al. 2011

Pathology Research International

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It is widely accepted that specific human papillomavirus (HPV) types are the central etiologic agent of cervical carcinogenesis. However, a number of infected women do not develop invasive lesions, suggesting that other environmental and host factors may play decisive roles in the persistence of HPV infection and further malignant conversion of cervical epithelium. Although many previous reports have focused on HPV and environmental factors, the role of host susceptibility to cervical carcinogenesis is largely unknown. Here, we review the findings of genetic association studies in cervical carcinogenesis with special reference to polymorphisms of glutathione-S-transferase (GST) isoforms, p53 codon 72, murine double-minute 2 homolog (MDM2) gene promoter 309, and FAS gene promoter -670 together with HPV types including our recent research results.

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Section: Mdm2-snp309mentioning

confidence: 99%

Section: Mdm2-snp309mentioning

confidence: 99%

Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis

Nunobiki

Ueda

Toji

et al. 2011

Pathology Research International

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“…Meissner et al [15] reported that no statistically significant association was observed between SNP309 and cervical cancer. In contrast, Arvanitis and Spandidos [18] demonstrated that MDM2 gene expression was found to be up-regulated in SIL by RT-PCR assay.…”

Section: Discussionmentioning

confidence: 99%

“…Although many studies have identified environmental factors associated with cervical cancinogenesis, the interaction between environmental and genetic factors remains to be elucidated. Previous reports have shown a direct relationship between increasing proliferation and progressive derailment of p53 and MDM2 [13] [14], however, there have been very few reports on the correlation between SNP of MDM2 gene and cervical cancer susceptibility [15]. In the present study, we investigated a polymorphism at codon 72 of the p53 gene and MDM2-SNP309 together with HPV types in exfoliated cervical cell samples from the patients with squamous intraepithelial lesion (SIL) of the cervix, and evaluated the biological significance of this genotype in cervical carcinogenesis in a Japanese population.…”

Section: Introductionmentioning

confidence: 99%

MDM2 SNP309 (rs2279744) and p53 Codon Arg72Pro (rs1042522) SNP in Cervical Carcinogenesis

Nunobiki¹,

Sawada²,

Ueda³

2014

ABB

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To investigate the association between polymorphisms (SNP) in the p53 and murine double minute 2 homolog (MDM2) promoter 309 in cervical carcinogenesis. SNP at p53 codon 72 polymorphisms and MDM2 promoter 309 (T/G) together with human papillomavirus (HPV) types were examined in a total of 187 cervical smear samples using real time PCR. 27 cases with HPV types 16 and/or 18 had significantly higher frequency of the TG + GG genotype and G allele than 56 with other types of high-risk HPV (P = 0.0136). 48 cases with HPV types 52 and/or 58 had significantly higher frequency of the TG + GG genotype and G allele than 56 with other types of high-risk HPV (P = 0.001). Our studies have demonstrated that the frequency of G allele in MDM2 promoter 309 increased from LSIL to HSIL and that there was an increased OR for G allele in HSIL cases with high-risk HPV types including 52 and 58. It is known that geographically different oncogenic HPV types 52 and 58 are more prevalent than 16 and 18 in a Japanese population.

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“…This second SNP neutralizes the effect of the 309 T>G transition in MDM2 , resulting in decreased MDM2 transcription [ 18 ]. There have been controversial findings demonstrating that the 309 MDM2 SNP is a susceptibility factor for the development of cervical cancer in disparate ethnicities [ 19 – 23 ].…”

Section: Introductionmentioning

confidence: 99%

Murine Double-Minute 2 Homolog Single Nucleotide Polymorphisms 285 and 309 in Cervical Carcinogenesis

et al. 2015

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Background and ObjectiveIn Caucasians, the MDM2 single nucleotide polymorphism (SNP) 285 G>C (rs117039649) neutralizes the effect of 309 T>G (rs2279744), which increases MDM2 expression and impairs the p53 pathway. In this study, we examined the distribution of these two SNPs in Polish women with squamous cell carcinoma (SCC) (n = 379), adenocarcinoma (n = 59) and other cervical tumor types (n = 18).MethodsThe polymerase chain reaction-restriction fragment length polymorphism technique and DNA sequencing were employed in our study.ResultsThe P trend value calculated for the MDM2 285 G>C polymorphism was statistically significant (Ptrend = 0.016) for SCC. Using logistical regression analysis adjusted for the effect of age, pregnancy, oral contraceptive use, tobacco smoking, and menopausal status, we observed that the MDM2 285 G>C SNP protected against SCC, with an adjusted odd ratio (OR) for the C carriers versus G/G genotype of 0.536 (P = 0.019). Stratified analyses of MDM2 285 G>C revealed a protective role of the C allele against SCC in women with a positive history of oral contraceptive use (age-adjusted OR 0.413, P = 0.021) and in premenopausal women (age-adjusted OR 0.362, P = 0.022). We also found that the 285GG/309GG vs 285GG/309 TT genotype increased the risk of SCC (adjusted OR 1.890, P = 0.005). However, the 285CC/309GG + 285GC/309GG versus 285GG/309GG genotype reduced the risk of SCC (adjusted OR 0.311, P = 0.004).ConclusionOur results demonstrate that the MDM2 285C gene variant and 285CC/309GG + 285GC/309GG genotypes protect against SCC, most likely by neutralizing the effect of the 309 T>G SNP. The 285GG/309GG genotype increases the risk of SCC possibly due to increased MDM2 expression.Electronic supplementary materialThe online version of this article (doi:10.1007/s40291-015-0153-4) contains supplementary material, which is available to authorized users.

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No association between SNP309 promoter polymorphism in the MDM2 and cervical cancer in a study from northeastern Brazil

Cited by 23 publications

References 16 publications

Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis

Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis

MDM2 SNP309 (rs2279744) and p53 Codon Arg72Pro (rs1042522) SNP in Cervical Carcinogenesis

Murine Double-Minute 2 Homolog Single Nucleotide Polymorphisms 285 and 309 in Cervical Carcinogenesis

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